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  1. 197941
    “…Resistance may be a result of the stress exposure or molecular level mutations conferring cross-resistance. Further in vivo and clinical data are needed to further assess the clinical implications of these findings. …”
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    2165. Assessing the Impact of Meropenem Exposure on Ceftolozane/tazobactam-resistance Development in Pseudomonas aeruginosa using in vitro Serial Passage
  2. 197942
    “…METHODS: An AmpC β-lactamase producing E. cloacae with porin mutations and a meropenem minimum inhibitory concentration (MIC) of 2μg/mL was used to make a starting model inoculum of 6 log(10) CFU/mL. …”
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    2550. Comparing Efficacy of Serum and Epithelial Lining Fluid Concentrations for Meropenem Against Carbapenem-Resistant Enterobacterales
  3. 197943
    “…Azole resistance in Aspergillus fumigatus (AFM) is a growing concern, mainly caused by mutations within CYP51 genes. The activity of ISC and other azoles against AFM causing IA worldwide was evaluated by applying the new CLSI ISC clinical breakpoints (BP). …”
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    2113. Evaluation of Isavuconazole Activity against Aspergillus fumigatus Causing Invasive Infections Worldwide Using the New CLSI Clinical Breakpoints
  4. 197944
    “…BACKGROUND: Currently circulating Omicron subvariants contain mutations permitting evasion of neutralization with prototype vaccines. …”
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    2337. Immunogenicity and Safety of a Heterologous Booster Dose of Omicron Subvariant (BA.1 and BA.5) and Bivalent SARS-CoV-2 Recombinant Spike Protein Vaccines: A Phase 3, Randomized, Clinical Trial
  5. 197945
    “…Evaluation of CH.1.1 and XBF by introducing variant-defining mutations into the replicon showed no change in in vitro susceptibility (< 1.8-fold change). …”
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    545. Remdesivir And Obeldesivir Retain Potent Activity Against SARS-CoV-2 Omicron Variants
  6. 197946
    “…PURPOSE: Mutations in the CACNA1F gene encoding the L-type calcium channel pore-forming Ca(v)1.4 (α1F) subunit in humans result in an incomplete form of congenital stationary night blindness (CSNB2) with residual photoreceptor function. …”
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    Abundant L-type calcium channel Ca(v)1.3 (α1D) subunit mRNA is detected in rod photoreceptors of the mouse retina via in situ hybridization
  7. 197947
    “…Tumour DNA was pyrosequenced for KRAS(c.146), BRAF, NRAS, and PIK3CA mutations, and predefined molecular subgroups were analysed for interaction with the effect of panitumumab. …”
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    Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial
  8. 197948
    por D'Angelo, Gianni, Rampone, Salvatore
    Publicado 2014
    “…The test data used in this study are IPDATA (Irvine Primate splice- junction DATA set), a subset of HS3D (Homo Sapiens Splice Sites Dataset) and a subset of COSMIC (the Catalogue of Somatic Mutations in Cancer). The execution time and the speed-up on IPDATA reach the best values within about 90 processors. …”
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    Towards a HPC-oriented parallel implementation of a learning algorithm for bioinformatics applications
  9. 197949
    “…Importantly, both miR-29b/c and miR-200b/c strongly decreased steady state levels of ADAM12-L protein in all breast cancer cell lines tested. miR-29b/c and miR-200b/c also significantly decreased the activity of an ADAM12-L 3′UTR reporter, and this effect was abolished when miR-29b/c and miR-200b/c target sequences were mutated. In contrast, miR-30b/d did not elicit consistent and significant effects on ADAM12-L expression. …”
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    ADAM12-L is a direct target of the miR-29 and miR-200 families in breast cancer
  10. 197950
    “…The frequency of kdr gene mutations was determined from a random sample of A. gambiaes.s. from both WHO susceptibility and cone bioassay experiments. …”
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    Bio-efficacy of new long-lasting insecticide-treated bed nets against Anopheles funestus and Anopheles gambiae from central and northern Mozambique
  11. 197951
    “…BCSCs could be derived from mutated mammary epithelial stem cells (MaSCs). Therefore, comparing the molecular differences between BCSCs and MaSCs may clarify the mechanism underlying breast carcinogenesis and the targets for gene therapy. …”
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    Essential role of miR-200c in regulating self-renewal of breast cancer stem cells and their counterparts of mammary epithelium
  12. 197952
    “…The genomes of Sus scrofa, the Tibetan boar, the African Bushpig, and the Warthog show sequence conservation of all inactivating HEPN1 mutations suggesting disruption before the evolutionary split of these pig species. …”
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    Functional analysis and transcriptional output of the Göttingen minipig genome
  13. 197953
    “…PDL1 and miR-34a expression were analyzed in samples from patients with NSCLC and mutated p53 vs wild-type p53 tumors from The Cancer Genome Atlas for Lung Adenocarcinoma (TCGA LUAD). …”
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    PDL1 Regulation by p53 via miR-34
  14. 197954
    “…RESULTS: Nine SNPs were identified in FASN, among which SNP rs41919985 was predicted to result in an amino acid substitution from threonine (ACC) to alanine (GCC), five SNPs (rs136947640, rs134340637, rs41919992, rs41919984 and rs41919986) were synonymous mutations, and the remaining three (rs41919999, rs132865003 and rs133498277) were found in FASN introns. …”
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    Genetic effects of FASN, PPARGC1A, ABCG2 and IGF1 revealing the association with milk fatty acids in a Chinese Holstein cattle population based on a post genome-wide association study
  15. 197955
    “…One subject in the R/F/TAF group had 2 blips prior to experiencing virologic rebound with mutations also detected at baseline (determined by retrospective proviral DNA sequencing). …”
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    Viral Blips Were Infrequent in HIV-1-Infected Virologically-Suppressed Adults Treated with Tenofovir Alafenamide or Tenofovir DF Rilpivirine-Containing Regimens
  16. 197956
    “…METHODS: 34 patients with Stargardt disease or cone rod dystrophy carrying confirmed mutations in ABCA4 were selected from our retinitis pigmentosa (RP) register. …”
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    Full-field ERG as a predictor of the natural course of ABCA4-associated retinal degenerations
  17. 197957
    “…BACKGROUND & AIMS: Inhibitors of the epidermal growth factor receptor (EGFR) are the first-line therapy for patients with metastatic colorectal tumors without RAS mutations. However, EGFR inhibitors are ineffective in these patients, and tumor level of EGFR does not associate with response to therapy. …”
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    EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients
  18. 197958
    “…BACKGROUND: Laron syndrome is an autosomal disease resulting from mutations in the growth hormone receptor (GHR) gene. …”
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    Generation of GHR-modified pigs as Laron syndrome models via a dual-sgRNAs/Cas9 system and somatic cell nuclear transfer
  19. 197959
    “…Antibodies developed preferentially in men with non-missense GLA mutations (relative risk 2.88, p = 0.006) and classic phenotype (58.6% (17/29) vs 6.7% (1/16), p = 0.0005). …”
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    Deep characterization of the anti-drug antibodies developed in Fabry disease patients, a prospective analysis from the French multicenter cohort FFABRY
  20. 197960
    “…METHODS: E. faecium R497 harboring liaSFR mutations (DAP MIC of 16 mg/L) was evaluated in a simulated endocardial vegetation (SEV) pharmacokinetic and pharmacodynamic model over 336 hours at a starting inoculum of 10(9) log10 CFU/g of SEV. …”
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    1399. Efficacy of Daptomycin Combination with β-Lactams for Daptomycin-resistant Enterococcus faecium Harboring LiaSR Substitutions
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