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7681“…After surgery, the levels of serum Cor, ET, NE and DA in the observation group were lower than those in the control group (p < 0.05). …”
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7682por Song, Yuqin, Zhou, Keshu, Zou, Dehui, Zhou, Jianfeng, Hu, Jianda, Yang, Haiyan, Zhang, Huilai, Ji, Jie, Xu, Wei, Jin, Jie, Lv, Fangfang, Feng, Ru, Gao, Sujun, Guo, Haiyi, Zhou, Lei, Huang, Jane, Novotny, William, Kim, Pil, Yu, Yiling, Wu, Binghao, Zhu, Jun“…Median progression-free survival (PFS) was 33.0 months (95% confidence interval [CI], 19.4-NE). The 36-month PFS and overall survival (OS) rates were 47.6% (95% CI, 36.2-58.1) and 74.8% (95% CI, 63.7-83.0), respectively. …”
Publicado 2022
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7683por Shi, Cong, Gong, Shengping, Wu, An, Niu, Tingting, Wu, Ningning, Zhang, Yi, Ouyang, Guifang, Mu, Qitian“…Multivariate cox proportional hazards regression analysis indicated that, in addition to older age, gender, lower HB, poorer karyotype for OS, lower NE, and higher bone marrow blast percentage for OS and LFS, elevated FIB level was also an independent adverse prognostic factor for OS (P = 0.045) but not for LFS (P = 0.188). …”
Publicado 2022
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7684por Wang, Hui, Wang, Hua, Zhang, Jin, Luo, Jiahui, Peng, Caidong, Tong, Xiaoyun, Chen, Xudong“…Crataegi Folium (known as Shanzhaye in China, SZ, the leaves of Crataegus pinnatifida Bge. var. major N.E. Br. or Crataegus pinnatifida Bge) and Alisma rhizoma (known as Zexie in China, ZX, the dried tuber of Alisma orientale (Sam.) …”
Publicado 2022
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7685“…Biochemical analysis showed that HLS enhanced the levels of 5-hydroxytryptamine (5-HT), norepinephrine (NE), and dopamine (DA) in the hippocampus and diminished these in the serum of the CUMS rats. …”
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7686“…The mean number of effective alleles (Ne) was found to be 2.15, Nei’s expected heterozygosity (H) 0.49, and Shannon’s information index (I) 0.81. …”
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7687por Wang, Tengfei, Wang, Liangliang, Qin, Haoliang, Zhao, Cong, Bai, Zongxian, Meng, Xingbang“…The results show that channeling channels chiefly develop along NE 60–70° and that foam could reduce gas channeling. …”
Publicado 2022
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7688por Nordin, Kristin, Gorbach, Tetiana, Pedersen, Robin, Panes Lundmark, Vania, Johansson, Jarkko, Andersson, Micael, McNulty, Charlotte, Riklund, Katrine, Wåhlin, Anders, Papenberg, Goran, Kalpouzos, Grégoria, Bäckman, Lars, Salami, Alireza“…Here, we present the DopamiNe, Age, connectoMe, and Cognition (DyNAMiC) project, a multimodal, prospective 5‐year longitudinal study spanning the adult human lifespan. …”
Publicado 2022
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7689por Bassano, Carlo, Pugliese, Marta, Mve Mvondo, Charles, Pisano, Calogera, Nardi, Paolo, Buioni, Dario, Bertoldo, Fabio, Scognamiglio, Mattia, Salvati, Alessandro C., Altieri, Claudia, Ruvolo, Giovanni“…The patients were grouped according to the extent of the performed surgical treatment: isolated replacement of the supracoronary ascending aorta (NE, no extension), replacement of the aortic root (PE, proximal extension), replacement of the aortic arch (DE, distal extension), and both (BE, bilateral extension). …”
Publicado 2022
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7690“…Moreover, ICY, LSFR, and IYSP could positively influence the production of nitric oxide (NO) and endothelin-1 (ET-1) secretion in human umbilical vein endothelial cells (HUVECs) and weaken the adverse impact of norepinephrine (NE) on the production of NO and ET-1. In addition, ICY, LSFR, and IYSP could provide significant protection to HUVECs against H(2)O(2) damage by increasing antioxidase levels to decrease the contents of reactive oxide species and malondialdehyde. …”
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7691por Zhang, Qingli, Peng, Li, Hu, Jialu, Li, Huichu, Jiang, Yixuan, Fang, Weiyi, Yan, Hongbing, Chen, Jiyan, Wang, Weimin, Xiang, Dingcheng, Su, Xi, Yu, Bo, Wang, Yan, Xu, Yawei, Wang, Lefeng, Li, Chunjie, Chen, Yundai, Zhao, Dong, Ge, Wenzhen, Bell, Michelle L., Gasparrini, Antonio, Ge, Junbo, Huo, Yong, Kan, Haidong“…FUNDING: This work was supported by the National Natural Science Foundation of China (92043301 and 92143301), Shanghai International Science and Technology Partnership Project (No. 21230780200), the Medical Research Council-UK (MR/R013349/1), and the Natural Environment Research Council UK (NE/R009384/1).…”
Publicado 2022
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7692“…Immunohistochemically, the NEC cells were diffusely positive for synaptophysin, with focal expressions of INSM1, chromogranin A and NCAM, whereas the adenocarcinoma cells were mostly negative for these NE markers. The Ki67 index was 90% at the hot spots in both types. …”
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7693por Schönewolf, Jule, Meyer, Ole, Engels, Paula, Schlickenrieder, Anne, Hickel, Reinhard, Gruhn, Volker, Hesenius, Marc, Kühnisch, Jan“…All images were evaluated by an expert group, and each diagnosis served as a reference standard for cyclic training and evaluation of the CNN (ResNeXt-101–32 × 8d). Statistical analysis included the calculation of contingency tables, areas under the receiver operating characteristic curve (AUCs) and saliency maps. …”
Publicado 2022
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7694por Tian, Yanhua, Li, Qingqing, Yang, Zhenlin, Zhang, Shu, Xu, Jiachen, Wang, Zhijie, Bai, Hua, Duan, Jianchun, Zheng, Bo, Li, Wen, Cui, Yueli, Wang, Xin, Wan, Rui, Fei, Kailun, Zhong, Jia, Gao, Shugeng, He, Jie, Gay, Carl M., Zhang, Jianjun, Wang, Jie, Tang, Fuchou“…The non-neuroendocrine (non-NE) tumors were correlated with increased inflammatory gene signatures and immune cell infiltrates in SCLC, which contributed to better responses to immune checkpoint inhibitors. …”
Publicado 2022
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7695por Dziwulska-Hunek, Agata, Szymanek, Mariusz, Matwijczuk, Arkadiusz, Leszczyński, Norbert, Niemczynowicz, Agnieszka, Myśliwa-Kurdziel, Beata“…The aim of the study was to measure the tensile strength of 4-year-old alfalfa leaves cultivated from seeds exposed to pre-sowing stimulation with He–Ne laser light for 1 or 5 min (designated respectively as F1 and F5) and alternating magnetic field with the exposure time of 1 or 5 min (respectively, L1 and L5). …”
Publicado 2022
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7696Efficacy and safety of amrubicin therapy after chemoimmunotherapy in small cell lung cancer patientspor Kushiro, Kohei, Watanabe, Satoshi, Goto, Yuka, Fujisaki, Toshiya, Yanagimura, Naohiro, Ohtsubo, Aya, Shoji, Satoshi, Nozaki, Koichiro, Tanaka, Tomohiro, Saida, Yu, Sato, Yusuke, Ota, Takeshi, Koshio, Jun, Hayashi, Yoshiki, Miyabayashi, Takao, Matsumoto, Naoya, Ichikawa, Kosuke, Koyama, Kenichi, Kikuchi, Toshiaki“…The median PFS and OS did not significantly differ between the sensitive and refractory groups [PFS; 3.1 (95% CI: 1.1–4.0) vs. 4.2 (95% CI: 2.3–4.8) months, P=0.1142, OS; 10.0 (95% CI: 5.2–14.8) vs. 10.4 (95% CI: 3.8–NE) months, P=0.5525]. The most common adverse event was grade ≥3 neutropenia, which occurred in 22 of 30 patients (73%), and 2 patients (7%) discontinued AMR due to adverse events. …”
Publicado 2022
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7697por Harris, Anna E., Metzler, Veronika M., Lothion-Roy, Jennifer, Varun, Dhruvika, Woodcock, Corinne L., Haigh, Daisy B., Endeley, Chantelle, Haque, Maria, Toss, Michael S., Alsaleem, Mansour, Persson, Jenny L., Gudas, Lorraine J., Rakha, Emad, Robinson, Brian D., Khani, Francesca, Martin, Laura M., Moyer, Jenna E., Brownlie, Juliette, Madhusudan, Srinivasan, Allegrucci, Cinzia, James, Victoria H., Rutland, Catrin S., Fray, Rupert G., Ntekim, Atara, de Brot, Simone, Mongan, Nigel P., Jeyapalan, Jennie N.“…Indeed, the increasing numbers of ADT-related treatment-emergent neuroendocrine-like prostate cancers (NePC), which lack AR and are thus insensitive to ADT, represents a major therapeutic challenge. …”
Publicado 2022
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7698por Liu, Yanyan, Wuxiao, Zhijun, Kong, Fancong, Feng, Jifeng, Wu, Jianqiu, Yao, Zhihua, Zhou, Weilun, Li, Fei“…The estimated median PFS of all patients was 200 [95% confidence interval (CI): 97 to not evaluable (NE)] days. The most common AEs were thrombocytopenia (32.1%), neutropenia (28.6%), and fever (14.3%). …”
Publicado 2022
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7699“…RoRα, S100β, IL-17A, IL-17Rc, IL-6, Iba-1, IDO enzyme and CORT concentrations were significantly increased, and Helios, FoxP3(+), STAT5 and TGF-β were significantly decreased by CUMS, which were significantly attenuated by IL-2 when compared to the CUMS group. The NE, DA and 5-HT contents and those of their metabolites were decreased by CUMS, which returned to control levels after IL-2 treatment. …”
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7700“…In the neuroendoscopy (NE) group, operation time (p < 0.00001), intraoperative blood loss volume (p < 0.0001), hematoma evacuation rate (p = 0.0002), complications (p < 0.00001), hospitalization days (p = 0.004), and mortality (p < 0.0001) were significantly different from those of the craniotomy (C) group, with a higher rate of good recovery compared with the craniotomy group (P < 0.00001). …”
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