“…BACKGROUND: Brain norepinephrine (NE) plays an important role in the modulation of stress response and neuroinflammation. …”
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“…At the same time, MMP-12, NE, and TIMP-4 in exhaled breath condensate (EBC) were also evaluated. …”
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“…OBJECTIVE: The objective of this study was to determine net energy (NE) of expeller-press (EP-RSM) and solvent-extracted rapeseed meal (SE-RSM) and to establish equations for predicting the NE in rapeseed meal (RSM) fed to growing pigs. …”
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“…RESULTS: The patients were categorized into the NocP (n=32) and NeP (n=18) groups. The mean VAS score of the NocP group was 59.3±3.1 mm and that of the NeP group was 73.6±4.6 mm. …”
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“…We first examined the effect of NE-100 administration on σ(1)R expression and found that cell surface levels of σ(1)R were significantly reduced in the NAc of NE-100 mice. …”
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“…Therefore, we aimed to explore donor NE support’s potential impact on outcomes in our single-center heart transplant cohort. …”
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“…METHODS: Single cell data of 4 normal samples, 3 CRPC samples and 3 CRPC-NE samples were obtained from GEO database, and CellChatDB was used for potential intercellular communication, Secondly, using the “limma” package (v3.52.0), we obtained the differential expressed genes between CRPC and CRPC-NE both in single-cell RNA seq and bulk RNA seq samples, and discovered 12 differential genes characterized by CRPC-NE. …”
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“…The uroepithelial cells gained from the mucosa of the bladder of a euthanized cat were cultured for 6 days and were acutely exposed to NE (10, 100, and 1000 µM) for 1 h. NE increased the metabolic activity of the cultured cells and elevated the extracellular concentrations of the pro-inflammatory mediators interleukin-6 (IL-6) and stromal cell derived factor 1 (SDF-1), confirming that NE can trigger an inflammatory response in the uroepithelium. …”
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“…Descriptive analyses were performed by NeP subtype. RESULTS: The prevalence of probable NeP was 14.5% (n=307). …”
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“…Karl Popper, "razionalista ed empirista", conduce da quasi quarant'anni una critica dall'interno al neoempirismo che ne rispetta il rigore, ne usa gli strumenti, ma ne supera i limiti.…”
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“…OBJECTIVES/SPECIFIC AIMS: (1) To delineate the function of the heavy-chain receptor binding domain (HCR), a portion of botulinum neurotoxin type A (BoNT/A) and synaptic vesicle 2 (SV2) signaling pathway, which provide a novel multipurpose biologic with potential clinical applications in tumor detection/imaging, inhibition of tumor progression, and reduction of bioactive hormone secretion in metastatic neuroendocrine (NE) cancers. (2) To evaluate the expression pattern of SV2 receptors in NE cancer patient-derived tissues for prediction of patient response for recombinant HCR (rHCR) treatment. (3) To assess the in vivo efficacy and toxicity of rHCR in a NE cancer liver metastasis mouse models and in the NE patient-derived 3D MicroTumor system. (4) To collect preclinical data to design and conduct a clinical trial with NE cancer patients, a major goal toward translating our discoveries into much needed therapies. …”
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“…Norepinephrine (NE) released from the nerve terminal of locus coeruleus (LC) neurons contributes to about 70% of the total extracellular NE in primates brain. …”
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“…Thymic neuroendocrine (NE) tumors are a rare manifestation of multiple endocrine neoplasia syndrome type 1 (MEN-1). …”
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“…Neuroendocrine (NE) differentiation is a common feature in prostate cancer (PC). …”
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“…The NE system is, therefore, the most accurate representation of energy available for productive purposes. …”
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“…The dynamic nature of the nuclear envelope (NE) is often underestimated. The NE protects, regulates, and organizes the eukaryote genome and adapts to epigenetic changes and to its environment. …”
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“…Norepinephrine (NE) neurons in the locus coeruleus (LC) play key roles in modulating sleep and wakefulness. …”
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“…The NE remained intact on the ultrastructural level during this time. …”
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“…A negative correlation was observed between FEV(1) and HNP, NE and IL-8 levels (p < 0.01), between FVC(1)/FVC and HNP, NE and IL-8 levels (p < 0.01), and between NE enrolment levels and FEV(1) decline after 2 years (p = 0.04). …”
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“…This membrane-binding ability allows CHMP7 to bind to the ER, an organelle continuous with the NE, and it provides a platform to direct NE recruitment of ESCRT-III during mitotic exit. …”
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