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  1. 2521
    “…Pulmonary Langerhans cell histiocytosis (PLCH) is a rare cystic lung disease. The natural history is often unpredictable making it difficult to diagnose. …”
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    Initial presentation of Pulmonary Langerhans cell histiocytosis as recurrent spontaneous pneumothoraces
  2. 2522
    “…Due to its rarity, the natural history of LCT is poorly understood. Patients can present with atypical symptoms and endocrine disorders. …”
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    Testicular leydig cell tumor revealed by hydrocele
  3. 2523
    “…Goblet cell carcinoid (GCC) is a rare neoplasm of the vermiform appendix and can be mistaken as a typical neuroendocrine tumour (TNET). The natural history of this disease is more aggressive compared to TNETs and requires a more aggressive approach. …”
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    A Case of Appendiceal Goblet Cell Carcinoid Tumor: Getting it right under the Microscope
  4. 2524
    “…Because of the limited cases the natural history, demography and treatment understanding of these are limited. …”
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    Completely Extradural Spinal Arteriovenous Fistula (Abnormal Direct Connection between Arteries and Extradural Venous Plexus) with Totally Extradural Venous Drainage Causing Compressive Cervical Myelopathy
  5. 2525
    “…Significant changes in the management of patients with de novo metastatic prostate cancer have led to the use of novel oral agents and docetaxel-based chemotherapy earlier in the natural history of their disease. Our main challenge is the lack of prospective randomized data comparing these regimens. …”
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    Volume matters and intensification is needed: emerging trends in the management of advanced prostate cancer
  6. 2526
    “…BACKGROUND: Essential tremor (ET) is a progressive neurological disease whose natural history is one of progressive increase in tremor severity over time; surprisingly though, there are no published videotape diaries that visually and tangibly portray this progression over time. …”
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    The Progression of Essential Tremors: Illustrative Videos
  7. 2527
    “…Seborrheic keratosis (SK) is a common epidermal tumor, consisting of a benign proliferation of immature keratinocytes. The natural history of SK is a slow progression over time and complete remission is not expected. …”
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    Inflammatory seborrheic keratosis resolution after hyperbaric oxygen therapy: Case presentation and pathophysiology review
  8. 2528
    “…We then review the clinical evaluation, natural history, and resulting instability for patients presenting with a hypermobile hip. …”
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    Hypermobile Disorders and Their Effects on the Hip Joint
  9. 2529
    “…This paper investigates the origin of the contraindication for mechanical thrombectomy, the natural history of large vessel occlusion, risks of craniectomy, and risks of mechanical thrombectomy. …”
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    A Case Report Examining a Contraindication for Mechanical Thrombectomy in the Setting of a Large Vessel Occlusion and a Concurrent Contralateral Intracranial Hemorrhage
  10. 2530
    por Kopparthy, Pallavi, Murphy, Martina
    Publicado 2021
    “…Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors with a natural history ranging from indolent benign lesions to ones with an aggressive clinical course including distant metastases. …”
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    Rapid and Durable Response With Nab-Sirolimus After Everolimus Failure in a Patient With Perivascular Epithelioid Cell Tumors (PEComas) of the Uterus
  11. 2531
    “…BACKGROUND: Historical natural history collections are very important for the study of nature and environmental protection of the environment, these being the depository of essential information. …”
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    Sixty years of work on Italy’s Orthopteroids biodiversity, the big data of Galvagni collection
  12. 2532
    “…Due to the low frequency in adults, no standard management guidelines are available for this population, also the natural history of the disease and management is unclear. …”
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    Adult Wilms' Tumor: Case Report and Literature Review
  13. 2533
    “…Osteochondromas are the most common benign bone tumor; nonetheless, the natural history is poorly understood as a result of the low threshold for resection and the fact that many of these lesions are asymptomatic and therefore never diagnosed. …”
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    Minor Shoulder Injury Reveals Spontaneous Regression of Proximal Humerus Osteochondroma
  14. 2534
    por Lanzarone, Giuseppe, Olivi, Matteo
    Publicado 2021
    “…Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized collectively by clonal proliferation of myeloid cells with variable morphologic maturity and hematopoietic efficiency. Although the natural history of these neoplasms can be measured sometimes in decades more than years, the cytogenetics analysis can offer useful information regarding the prognosis. …”
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    The Prognostic Role of Cytogenetics Analysis in Philadelphia Negative Myeloproliferative Neoplasms
  15. 2535
    “…The natural history of most thrombi undergoes total or near total resolution, but the thrombi in chronic thromboembolic pulmonary hypertension (CTEPH) do not resolve completely and subsequently increase the pulmonary vascular resistance. …”
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    Elevated lipoprotein A in acute on chronic CTEPH with cardiogenic shock: a case report
  16. 2536
    “…This paper summarises what is known about the natural history of severe aortic stenosis and the scientific evidence available about the optimal timing for aortic valve replacement.…”
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    Timing of Intervention in Asymptomatic Patients with Aortic Stenosis
  17. 2537
    “…Monoclonal antibodies (mAb) for indolent non-Hodgkin's lymphoma (iNHL) including follicular and marginal zone lymphomas was a key therapeutic development that changed the natural history of these diseases. Rituximab, a chimeric anti-CD20 mAb, was the first immunotherapy ever used in cancer, and a current cornerstone of lymphoma therapies. …”
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    Role of antibody-based therapy in indolent non-Hodgkin's lymphoma
  18. 2538
    “…Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and, ultimately, kidney failure. …”
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    Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis
  19. 2539
    “…Using evidence from paleoecology/palaeoanthropology and data from the physiology of modern humans, we try to assess the natural history of TH signalling and its role in human evolution. …”
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    Thyroid Hormone Signalling in Human Evolution and Disease: A Novel Hypothesis
  20. 2540
    “…Basilar artery perforator aneurysms (BAPA's) are a rare entity. Their natural history and treatment are unclear. We describe the largest BAPA reported thus far in literature in a 64-year-old Caucasian woman. …”
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    A giant basilar artery perforator aneurysm
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