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  1. 2561
    por Cahan, Eli M., Frick, Steven L.
    Publicado 2019
    “…Stratification of these analyses by sex revealed distinctive differences in disease natural history and clinical management course. CONCLUSIONS: These findings describing the orthopaedic natural history and standard of care in patients with NGLY1 deficiency can facilitate diagnosis, inform prognosis, and guide treatment recommendations in an evidence-based manner. …”
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    Orthopaedic phenotyping of NGLY1 deficiency using an international, family-led disease registry
  2. 2562
    “…Our study also provides guidance for the development of animal models by describing the natural history of disease and therapeutic validation. …”
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    2202. Validation of a Rabbit Model of Pseudomonas aeruginosa Acute Pneumonia
  3. 2563
    “…Our specific findings are as follows: (1) The majority of North American natural history collections (88%) and specimens (89%) are located in the United States. …”
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    Assessment of North American arthropod collections: prospects and challenges for addressing biodiversity research
  4. 2564
    “…METHODS: In this 6-month natural history assessment (n = 37) followed by a randomized, double-blinded, placebo-controlled trial, 33 eligible participants were block-randomized (1:1) to receive NAC (n = 16) or placebo (n = 17), orally for 6 months (adult dose 2,700 mg/d; pediatric dose 30 mg/kg/d). …”
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    Randomized controlled trial of N-acetylcysteine therapy for RYR1-related myopathies
  5. 2565
    “…OBJECTIVES: Our objective was to report the baseline clinical characteristics, natural history, and associated outcomes of patients with HS from the ongoing, prospective, non-interventional UNITE registry that is collecting data regarding the natural history and associated outcomes of HS. …”
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    Baseline Characteristics from UNITE: An Observational, International, Multicentre Registry to Evaluate Hidradenitis Suppurativa (Acne Inversa) in Clinical Practice
  6. 2566
    “…RESULT: The natural history scenario is projected to have the fewest HBsAg losses (27.59 million) and highest number of HBV-related deaths (27.19 million). …”
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    Disease burden of chronic hepatitis B and complications in China from 2006 to 2050: an individual-based modeling study
  7. 2567
    “…In addition, SPARKLE will expand the current understanding of alpha-mannosidosis by collecting data on the clinical manifestations, progression, and natural history of the disease in treated and untreated patients, respectively. …”
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    The SPARKLE registry: protocol for an international prospective cohort study in patients with alpha-mannosidosis
  8. 2568
    “…However, information on the clinical, histopathologic, and direct immunofluorescence (DIF) features among subtypes of cutaneous lupus erythematosus (CLE), as well as longitudinal prospective observational study to evaluate the natural history and the progression to SLE, is lacking among Asians. …”
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    Dermatologic Manifestations, Histologic Features and Disease Progression among Cutaneous Lupus Erythematosus Subtypes: A Prospective Observational Study in Asians
  9. 2569
    “…The precise timing of comorbidity onset and the natural history of many of the skeletal dysplasia features are incompletely defined. …”
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    Design and Baseline Demographics of a Five-Year, Multi-National Observational Cohort Study of Children With Achondroplasia (ACHieve Study)
  10. 2570
    “…BACKGROUND: Understanding the natural history of rare bone and mineral conditions is essential for improving clinical practice and the development of new diagnostics and therapeutics. …”
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    Patients’ priorities and expectations on an EU registry for rare bone and mineral conditions
  11. 2571
    “…Data sources and methods to estimate four types of input parameters including health-related quality of life (HRQoL); natural history; treatment effect; resource use were extracted and appraised. …”
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    Systematic review of the evidence sources applied to cost-effectiveness analyses for older women with primary breast cancer
  12. 2572
    “…We sought to summarize the literature on the natural history of SMA and the impact of SMA DMTs, including health-related quality of life (HRQOL) and utilities, clinical efficacy and safety, and economic impact. …”
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    Systematic Literature Review of Clinical and Economic Evidence for Spinal Muscular Atrophy
  13. 2573
    “…These results indicate that the natural history of LSS differs according to grade of maximal central and foraminal stenoses.…”
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    Probability for surgical treatment in patients with lumbar spinal stenosis according to the stenotic lesion severity: a 5–10-year follow-up study
  14. 2574
    “…As a result, precise information of demographics, clinical features, and about the natural history of these conditions are lacking. METHODS: The ITAlian tremor Network (TITAN) is a multicenter data collection platform, the aim of which is to prospectively assess, according to a standardized protocol, the phenomenology and natural history of tremor syndromes. …”
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    The Italian tremor Network (TITAN): rationale, design and preliminary findings
  15. 2575
    “…Unfortunately, the porphyrias are usually underrecognized reflecting a lack of medical and disease awareness as well as few studies about natural history in large cohorts of patients. The main aim of this article is present consistent data about natural history and burden of disease in a large Brazilian cohort. …”
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    Brazilian registry of patients with porphyria: REBRAPPO study
  16. 2576
    por Choudhury, Hasan, Abidoye, Oluseyi
    Publicado 2023
    “…These tumors are also known as aggressive fibromatosis and have an unpredictable natural history that varies depending on risk factors. …”
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    A Desmoid Tumor Responding to Systemic Therapy With Tamoxifen and Sulindac
  17. 2577
    “…Lastly, the distribution, natural history, and conservation status of the new species are discussed.…”
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    A new Bolitoglossa (Amphibia, Caudata, Plethodontidae) from the Cordillera Oriental of Colombia
  18. 2578
    “…This review will present the current literature data on the natural history and pathophysiology of the disease, and will highlight the role of imaging in the prompt and accurate diagnosis as well as in the imaged-guided treatment with emphasis on ultrasonography.…”
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    The role of MRI and Ultrasonography in Diagnosis and Treatment of Glenohumeral Joint Adhesive Capsulitis
  19. 2579
    por Mohammed, Wael A, Zaki, Mohamed A
    Publicado 2023
    “…In addition, understanding disease progression by tracing monkeypox cases provides valuable information on the disease's natural history, including the timeline and sequence of symptoms, associated complications, and outcomes, to avoid any small chance related to our lack of validated knowledge or incorrect assessment of the disease or the associated complications between an exposure and an effect in the target organs.…”
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    Adrenal Insufficiency Secondary to Monkeypox Infection: A Case Report
  20. 2580
    por Kancheva, Mihaela, Neychev, Vladimir
    Publicado 2023
    “…Reporting new cases will contribute to improving our understanding of the biology, natural history, and management of this rare pathological combination.…”
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    Synchronous Acute Appendicitis and Acute Cholecystitis: A Case Report
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