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  1. 2741
    “…In particular, ICI-induced hepatitis is diagnostically challenging given its variable natural history and clinical manifestations. The onset of ICI-induced hepatitis often occurs between 6 and 14 weeks after treatment initiation and rarely exhibits delayed presentations or manifests after treatment cessation. …”
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    Very Delayed Acute Hepatitis after Pembrolizumab Therapy for Advanced Malignancy: How Long Should We Watch?
  2. 2742
    “…In recent years, an increasing interest in the influence of diet in rheumatic and musculoskeletal diseases (RMDs) led to the publication of several articles exploring the role of food/nutrients in both the risk of developing these conditions in normal subjects and the natural history of the disease in patients with established RMDs. …”
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    Diet in Rheumatoid Arthritis versus Systemic Lupus Erythematosus: Any Differences?
  3. 2743
    “…We believe that the new phenotype definitions implemented by recent large multicenter studies, and revised here, may contribute to a more homogeneous patient categorization, which will be useful in future studies on natural history and clinical trials.…”
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    Mitochondrial Syndromes Revisited
  4. 2744
    por Noorali, Sima, Haghighi, Shirin
    Publicado 2021
    “…Neuroendocrine tumors of the gastrointestinal tract and pancreas include a range of rare and diverse neoplasms with unique tumor biology, natural history, and clinical management. Neuroendocrine tumors of the ampulla of Vater are extremely uncommon cancers that account for only about 0.3%-1% of all gastrointestinal neuroendocrine tumors. …”
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    Treatment of ampullary neuroendocrine tumor by Capecitabine (Xeloda®) and Temozolomide (Temodal®)
  5. 2745
    “…In this review, we discuss the natural history of NASH and sarcopenia, explore the interplay between these conditions in the scope of MS, and seek to better define how an assessment of muscle mass, strength, and functionality in this population is key to improved diagnosis and management of patients with sarcopenia and NASH.…”
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    Presence and Implications of Sarcopenia in Non-alcoholic Steatohepatitis
  6. 2746
    “…This is a review of the published contributions made by Brazilian researchers between 2010 and 2020 on the natural history of human toxocariasis and the effects of human toxocariasis on nonhuman paratenic hosts.…”
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    Human Toxocariasis: 2010 to 2020 Contributions from Brazilian Researchers
  7. 2747
    “…This review discusses the natural history of moderate aortic stenosis along with the role of multimodality imaging in risk stratification in these patients.…”
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    Moderate Aortic Stenosis: What is it and When Should We Intervene?
  8. 2748
    “…Brain AVMs are rare but serious vascular lesions that often pose a management dilemma between the risk of various treatment modalities and uncertain natural history during observation. We describe preliminary data on the use of focused ultrasound as a novel therapeutic strategy. …”
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    Focused Ultrasound Ablation of an Arteriovenous Malformation Model
  9. 2749
    “…Although malignant melanoma is the third most common cutaneous cancer, it is recognized as the main cause of skin cancer-related mortality, and its incidence is rising. The natural history of malignant melanoma involves an inconsistent and insidious skin cancer with great metastatic potential. …”
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    A Review of Epidemiology and Cancer Biology of Malignant Melanoma
  10. 2750
    por McLaren, Paul J., Fellay, Jacques
    Publicado 2021
    “…Over the past four decades, research on the natural history of HIV infection has described how HIV wreaks havoc on human immunity and causes AIDS. …”
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    HIV-1 and human genetic variation
  11. 2751
    por Hong, Simon J., Katz, Seymour
    Publicado 2021
    “…Compared with patients with onset during their younger years, patients with elderly onset IBD have a distinct clinical presentation, disease phenotype, and natural history. Genetics contribute less to pathogenesis of disease, whereas biological changes associated with aging including immunosenescence, dysbiosis, and frailty have a greater impact on disease outcomes. …”
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    The elderly IBD patient in the modern era: changing paradigms in risk stratification and therapeutic management
  12. 2752
    “…In this article, we have reviewed the natural history, clinical features, and imaging features of each onset pattern of moyamoya disease.…”
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    Differences in Clinical Features among Different Onset Patterns in Moyamoya Disease
  13. 2753
    “…The immunological status of the host has an impact on the natural history of herpes zoster (HZ). Age is a major risk factor for most of the cases of HZ. …”
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    A Rare Case of Herpes Zoster in an Adult Patient Recovered From Symptomatic Reinfection of COVID-19
  14. 2754
    “…It is, however, a reversible condition and early recognition and intervention can alter its natural history and associated complications.…”
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    The Troubling Link Between Non-alcoholic Fatty Liver Disease (NAFLD) and Extrahepatic Cancers (EHC)
  15. 2755
    “…The clinical use of molecularly targeted drugs, such as proteasome inhibitors and immunomodulatory agents, monoclonal antibodies such as daratumumab, and risk-adjusted autologous stem cell transplant in eligible patients, has radically changed the natural history of AL amyloidosis. Here, we review the state-of-the-art treatment landscape in AL amyloidosis with an eye toward future therapeutic venues to impact the outcome of this devastating illness.…”
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    AL Amyloidosis: Current Chemotherapy and Immune Therapy Treatment Strategies: JACC: CardioOncology State-of-the-Art Review
  16. 2756
    “…To our knowledge, this is the first reported case of an enlarging symptomatic TV cyst with spontaneous rupture and resolution of symptoms, highlighting the variable natural history of this condition.…”
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    Recurrent terminal ventricle cyst: a case report
  17. 2757
    “…The pathogenesis, natural history, and management strategy of anterior cervical meningocele (ACM) are uncertain. …”
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    Anterior cervical meningocele with craniovertebral junction instability – A case report and literature review
  18. 2758
    “…Little knowledge is available about natural history, behavior, prognosis, and best management guidelines of such tumor. …”
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    Purely Suprasellar (Hypothalamic) Atypical Teratoid Rhabdoid Tumor Presenting with Diabetes Insipidus and Panhypopituitarism in an Adult Male: A Case Report and Review of Literature
  19. 2759
    “…Advanced diagnostic and management strategies effectively influence the natural history of HCM.…”
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    Cardiac magnetic resonance in the assessment of hypertrophic cardiomyopathy phenotypes and stages – pictorial review
  20. 2760
    por Fu, Jennifer, Retnakaran, Ravi
    Publicado 2022
    “…In identifying high-risk women early in the natural history of these conditions, the diagnosis of GDM raises the tantalizing possibility of early intervention and risk modification. …”
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    The life course perspective of gestational diabetes: An opportunity for the prevention of diabetes and heart disease in women
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