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  1. 3121
    “…Many pathways (RTKs, PI3K/AKT/mTOR, angiogenesis, etc.) have been identified in GBM as playing major roles in tumorigenesis, treatment resistance, or natural history of disease. Despite the growing understanding of the complex networks regulating GBM tumors, many targeted therapies have fallen short of expectations. …”
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    Novel Therapies in Glioblastoma
  2. 3122
    “…Recent interest in the natural history of the virus has been stimulated by increasing recognition of LCMV infections during pregnancy, and in clusters of LCMV-associated fatal illness among tissue transplant recipients. …”
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    High Diversity and Ancient Common Ancestry of Lymphocytic Choriomeningitis Virus
  3. 3123
    “…In spite of the widespread extension of the disease, she survived for 13 years and died from a carcinoid heart disease. We discuss the natural history and prognostic factors in patients with midgut well-differentiated neuroendocrine tumors, with a focus on the impact of the peritoneal carcinomatosis.…”
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    Prolonged Survival in a Patient with Neuroendocrine Tumor of the Cecum and Diffuse Peritoneal Carcinomatosis
  4. 3124
    por Novo, Erica, Parola, Maurizio
    Publicado 2012
    “…In this chapter major concepts and mechanisms in redox signaling will be briefly recalled to introduce a number of selected examples of redox-related mechanisms that can actively contribute to critical events in the natural history of a chronic liver diseases, including induction of cell death, perpetuation of chronic inflammatory responses and fibrogenesis. …”
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    The role of redox mechanisms in hepatic chronic wound healing and fibrogenesis
  5. 3125
    “…This paper summarizes the recent developments in approaches to rectal cancer surgery at all these time points of the disease natural history.…”
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    Approach to Rectal Cancer Surgery
  6. 3126
    por Baildam, Eileen
    Publicado 2012
    “…Polyarticular juvenile idiopathic arthritis (JIA) is a category of JIA where multiple joints are affected by chronic inflammation, and where serious and lasting damage to joints is the expected natural history in untreated disease. There is evidence of response to disease-modifying antirheumatic and biologic drugs, but little evidence of permanent remission from any of the existing therapeutic trials. …”
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    A commentary on TREAT: The trial of early aggressive drug therapy in juvenile idiopathic arthritis
  7. 3127
    “…There are very few data available regarding the natural history, quality of life and risk factors of constipation in our country. …”
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    Constipation in Iran: SEPAHAN Systematic Review No. 5
  8. 3128
    “…Recent studies using serial MRI, which represents the “gold standard” for the early detection of osteonecrosis, yielded some interesting findings about the natural history of this clinical entity. Osteonecrosis in the majority of the cases is asymptomatic and occurs early in the course of the disease. …”
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    Osteonecrosis in Systemic Lupus Erythematosus: An Early, Frequent, and Not Always Symptomatic Complication
  9. 3129
    “…The study shows that a combination of natural history and experimental data can help understand the life history of a butterfly using a plant with high predation risk.…”
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    Morphology and Behavior of the Early Stages of the Skipper, Urbanus esmeraldus, on Urera baccifera, an Ant—Visited Host Plant
  10. 3130
    “…We review current concepts of anatomic classification, pathophysiology, natural history, and clinical management of bicuspid aortic valve disease with associated ascending aortic aneurysms.…”
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    Bicuspid Aortic Valve Disease and Ascending Aortic Aneurysms: Gaps in Knowledge
  11. 3131
    “…Merkel cell carcinoma of the head and neck (MCCHN) presents a clinical challenge due to its aggressive natural history, unpredictable lymphatic drainage, and high degree of treatment related morbidity. …”
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    A Review of Radiotherapy for Merkel Cell Carcinoma of the Head and Neck
  12. 3132
    “…There is an urgent need for well-designed prospective studies to fully delineate the natural history and risk factors associated with posttransplant MS. …”
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    Posttransplant Metabolic Syndrome
  13. 3133
    “…In this report, the natural history of the H5N1 influenza virus A/Vietnam/1203/04 influenza infection in ferrets was examined to determine clinical and laboratory parameters that may indicate (1) the onset of disease and (2) survival. …”
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    Early Indicators of Disease in Ferrets Infected with a High Dose of Avian Influenza H5N1
  14. 3134
    por Chien, A. Jo, Rugo, Hope S.
    Publicado 2012
    “…The widespread use of trastuzumab in the past decade has led to a significant and measureable improvement in the survival of patients with human epidermal growth factor receptor-2 (HER2) overexpressing breast cancer, and in many ways has redefined the natural history of this aggressive breast cancer subtype. …”
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    Emerging treatment options for the management of brain metastases in patients with HER2-positive metastatic breast cancer
  15. 3135
    “…Despite the significance of this virus in RTR, there is an overall deficiency in the understanding of the natural history of HPV infection in male RTR. In the next 20 years, it is believed that cancers will be the leading cause of death in kidney transplant recipients. …”
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    Male human papillomavirus infection post-kidney transplant: an overlooked disease
  16. 3136
    “…We conclude by posing hypotheses regarding how pathogen natural history influences transmission variability and highlight emerging frontiers in this area of study.…”
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    From superspreaders to disease hotspots: linking transmission across hosts and space
  17. 3137
    “…We present a case along with an outline for the natural history of the disease with a review of the literature of the reported cases dating back to 1895. …”
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    Neuromuscular hamartoma of the sciatic nerve: Case report and review of the literature
  18. 3138
    “…Introduction: Os odontoideum is a rare condition with a controversial pathogenesis and poorly understood natural history. As a result, it is difficult for clinicians to predict which patients require surgical fusion to prevent symptomatic progression and potentially devastating neurologic injury. …”
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    Addressing the challenges and controversies of managing os odontoideum: results of a systematic review
  19. 3139
    “…Consequently, the natural history of the disease in HIV-negative individuals and the optimum treatment are not well characterized. …”
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    Plasmablastic lymphoma of the maxillary sinus in an HIV-negative patient: a case report and literature review
  20. 3140
    “…He had showed failure in natural history and conservative management relief in both symptomatic and functional improvement, due to injury to the intervertebral joints of his lower lumbar spine. …”
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    Early adolescent lumbar intervertebral disc injury: a case study
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