“…We find that ASL is prominently expressed in the nucleus locus coeruleus (LC), the central source of norepinephrine. Using natural history data, we show that individuals with ASL deficiency are at risk for developing attention deficits. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Direct sarcomere modulators that can positively influence the natural history of cardiomyopathies represent promising treatment options.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To align with this perspective, nine new abnormal specimens displaying healed injuries from the Smithsonian National Museum of Natural History collection are documented. The injury pattern conforms to the suggestion of lateralised prey defence or predator preference, but it is highlighted that the root cause for such patterns is obscured by the lumping of data across different palaeoecological and environmental conditions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It also shows that ASD in PA is gender balanced and it is diagnosed at older ages (median age 8 years) than in the national registry for autism (median age 4.3 years), which raises the possibility, among others, of PA specific risk factors affecting the natural history of ASD. Data from patient registries provide valuable information on studying the mechanisms involved in a rare disease, although more outreach effort must be done to increase participation and consistency in data entry.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: We reviewed the clinical manifestations, natural history and treatment of dCTDs, since the implementation of Highly Active Anti-Retroviral Therapy (HAART), and the emergence of new pathogenic mechanisms, such as the immune reconstitution inflammatory syndrome. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Due to the poor knowledge of CTD-ILD’s natural history and due to the difficulties related to design of randomized control trials, there is a lack of prospective data about the prevalence, follow-up, and therapeutic efficacy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Perinatal viral infections need to be recognized as early in life as possible so that their natural history can be more completely defined and any possible intervention made.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the past, there has been a paucity of information and limited understanding regarding their pathogenesis, natural history, imaging findings, and histopathologic features, which often resulted in enormous diagnostic challenges and confusion. …”
Enlace del recurso
Enlace del recurso

“…A thorough understanding of the pathophysiology and clinical manifestation aids in understanding the natural history of these conditions. Recent developments in radiological and biomarker investigations have potential to provide noninvasive alternatives to the gold standard, invasive discogram. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Non-alcoholic steatohepatitis (NASH) is a progressive condition, characterized by liver inflammation and hepatocyte ballooning, with or without fibrosis. The natural history of NAFLD is negatively influenced by NASH onset and by the progression towards advanced fibrosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…With increasing knowledge about the natural history and management guidelines, the prognosis of this rare and unique entity has improved in recent years.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Nonetheless, a substantial number of these patients have a poor prognosis and consequently succumb to their illness within a year of diagnosis. The natural history of CUP is characterised by early metastasis from the unknown primary site, aggressive course and resistance to conventional chemotherapy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Advanced RCC often remains clinically silent for much of its natural history. This can make the diagnosis challenging, especially when presenting symptoms arise from a metastasis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Biomarkers for each condition have been well-documented and their proper selection helps to perform accurate clinical diagnoses. Based on the natural history of disorders, it is now evident that the existing treatment becomes most effective when initiated during presymptomatic period. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Advances in the development and validation of non-invasive biomarkers and imaging modalities will facilitate diagnosis for affected children and adolescents and facilitate long-term natural history studies and the development of therapeutic interventions.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This chapter provides an overview of the natural history, anatomy, physiology, clinical examination, common diseases, and treatment of rats (Rattus norvegicus) and mice (Mus musculus) in the context of veterinary medicine. …”
Enlace del recurso
Enlace del recurso

“…The results suggest that diabetes might be the most consistent comorbidity predicting disease severity and that future research should carefully consider the comparability of reporting cases, factors, and outcomes along the different stages of the natural history of covid-19.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Metastasis is the primary cause of cancer-related deaths, but the natural history, clonal evolution and impact of treatment are poorly understood. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, there are still many unresolved issues concerning oxidative stress, such as the correlation between the natural history of the disease and promising treatment protocols. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This study describes the natural history of dengue virus (DENV) infection in rhesus monkeys exposed to the bites of DENV-infected Aedes aegypti mosquitoes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso