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3361por Goodspeed, Kimberly, Liu, Judy S., Nye, Kimberly L., Prasad, Suyash, Sadhu, Chanchal, Tavakkoli, Fatemeh, Bilder, Deborah A., Minassian, Berge A., Bailey, Rachel M.“…Here, we discuss SLC13A5 genetics, natural history, available treatments, potential outcomes and assessments, and considerations for translational medical research for an AAV9-based gene replacement therapy.…”
Publicado 2022
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3362por Hernández-Pliego, Adriana, Vergara-Ortega, Dayana Nicté, Herrera-Ortíz, Antonia, Toledano-Jaimes, Cairo, Esquivel-Guadarrama, Fernando R., Sánchez-Alemán, Miguel Ángel“…Much is known about the natural history of syphilis; however, less is known about the immune response against it, and even less is known about people living with HIV (PLWH). …”
Publicado 2022
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3363por Soto, William“…Examples are given of how microbial selection studies can be used to examine the roles of chance, contingency, and determinism (natural selection) in shaping Earth’s natural history.…”
Publicado 2022
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3364por Arshad, Faheem, MM, Samim, Paplikar, Avanthi, Rajendran, Srijithesh, Kalkonde, Yogesh, Alladi, Suvarna“…There is limited evidence on the natural history of vascular disease from longitudinal cohorts in India. …”
Publicado 2021
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3365“…As we move forward, translational research combining basic science advances and clinical findings as well as studies focusing on natural history following RVCL-S patients at different disease stages, will be critical to help elucidate RVCL-S pathophysiology. …”
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3366“…Giant vertebral-basilar aneurysms are rare and represent 1% of intracranial aneurysms. Natural history and treatment are associated with severe clinical manifestations, such as ischemia, mass effect, hydrocephalus, and subarachnoid hemorrhage, leading to high mortality and morbidity. …”
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3367“…The specimen that we sequenced was the Y. tetricus holotype in the Natural History Museum, London, leaving no doubt that we are dealing with this species. …”
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3368por Zedde, Marialuisa, Pascarella, Rosario, Cavallieri, Francesco, Pezzella, Francesca Romana, Grisanti, Sara, Di Fonzo, Alessio, Valzania, Franco“…The data are currently scarce, but it is possible to hypothesize the molecular mechanisms of cell damage that support this association; this topic is worthy of further study in particular in relation to the therapeutic possibilities, which have significantly modified the natural history of the disease but which are not specifically dedicated to the CNS. …”
Publicado 2022
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3369por Braker, Emily M.“…This paper describes the wet imaging components and focus stack photography workflow developed while conducting a large-scale digitization project for targeted reptile and amphibian specimens housed in the University of Colorado Museum of Natural History Herpetology Collection. This methodology can be implemented in other collections settings and adapted for use with fluid-preserved specimen types across the Tree of Life to generate high-quality, taxonomically informative images for use in documenting biodiversity, remote examination of fine traits, inclusion in publications, and educational applications.…”
Publicado 2022
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3370“…Further research into the natural history of patients with AD dementia is necessary to improve identification of early AD and to better understand its broader impact.…”
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3371por Van Bortel, Wim, Versteirt, Veerle, Dekoninck, Wouter, Hance, Thierry, Brosens, Dimitri, Hendrickx, Guy“…Three different MODIRISK datasets were published in the Global Biodiversity Information Facility (GBIF): the Collection dataset (the Culicidae collection of the Museum of Natural History in Brussels); the Inventory dataset (data from the MODIRISK inventory effort); and the Longitudinal dataset (experiment data used for risk assessments).…”
Publicado 2022
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3372por Papiri, Giulio, D’Andreamatteo, Giordano, Cacchiò, Gabriella, Alia, Sonila, Silvestrini, Mauro, Paci, Cristina, Luzzi, Simona, Vignini, Arianna“…Its pathogenesis, in parallel with the well-established role of mechanisms pertaining to autoimmunity, involves several key functions of immune, glial and nerve cells. The disease’s natural history is complex, heterogeneous and may evolve over a relapsing-remitting (RRMS) or progressive (PPMS/SPMS) course. …”
Publicado 2023
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3373Metabolomics as a powerful tool for diagnostic, pronostic and drug intervention analysis in COVID-19“…Here we review the extensive literature on metabolomics in COVID-19, that unraveled many aspects of the disease including: a characteristic metabotipic signature associated to COVID-19, discrimination of patients according to severity, effect of drugs and vaccination treatments and the characterization of the natural history of the metabolic evolution associated to the disease, from the infection onset to full recovery or long-term and long sequelae of COVID.…”
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3374por Ariceta, Gema, Beck-Nielsen, Signe Sparre, Boot, Annemieke M., Brandi, Maria Luisa, Briot, Karine, de Lucas Collantes, Carmen, Emma, Francesco, Giannini, Sandro, Haffner, Dieter, Keen, Richard, Levtchenko, Elena, Mӓkitie, Outi, Mughal, M. Zulf, Nilsson, Ola, Schnabel, Dirk, Tripto-Shkolnik, Liana, Liu, Jonathan, Williams, Angela, Wood, Sue, Zillikens, M. Carola“…As a chronic disease resulting in progressive accumulation of musculoskeletal manifestations, it is important to understand the natural history of XLH over the patient’s lifetime and the impact of drug treatments and other interventions. …”
Publicado 2023
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3375“…The quantity and quality of these TSS in a genome strongly reflect the natural history of a bacterium. We propose that the Genomic- TSSR can be used as a subjective biomarker to represent the phyletic status of a bacterium.…”
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3376por Ito, Tetsuhide, Igarashi, Hisato, Uehara, Hirotsugu, Berna, Marc J., Jensen, Robert T.“…Because effective treatments have been developed for the hormone excess state, which was a major cause of death in these patients in the past, coupled with the recognition that nonendocrine tumors increasingly develop late in the disease course, the natural history of the disease has changed. An understanding of the current causes of death is important to tailor treatment for these patients and to help identify prognostic factors; however, it is generally lacking. …”
Publicado 2013
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3377“…Genotype-phenotype correlations have been well described; however, the natural history of the trajectory toward renal failure is not well described. …”
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3378por Dufouil, Carole, Dubois, Bruno, Vellas, Bruno, Pasquier, Florence, Blanc, Frédéric, Hugon, Jacques, Hanon, Olivier, Dartigues, Jean-François, Harston, Sandrine, Gabelle, Audrey, Ceccaldi, Mathieu, Beauchet, Olivier, Krolak-Salmon, Pierre, David, Renaud, Rouaud, Olivier, Godefroy, Olivier, Belin, Catherine, Rouch, Isabelle, Auguste, Nicolas, Wallon, David, Benetos, Athanase, Pariente, Jérémie, Paccalin, Marc, Moreaud, Olivier, Hommet, Caroline, Sellal, François, Boutoleau-Bretonniére, Claire, Jalenques, Isabelle, Gentric, Armelle, Vandel, Pierre, Azouani, Chabha, Fillon, Ludovic, Fischer, Clara, Savarieau, Helen, Operto, Gregory, Bertin, Hugo, Chupin, Marie, Bouteloup, Vincent, Habert, Marie-Odile, Mangin, Jean-François, Chêne, Geneviève“…BACKGROUND: The natural history and disease mechanisms of Alzheimer’s disease and related disorders (ADRD) are still poorly understood. …”
Publicado 2017
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3379por Belaunzarán-Zamudio, Pablo F., Rincón León, Héctor Armando, Caballero Sosa, Sandra, Ruiz, Emilia, Nájera Cancino, José Gabriel, de La Rosa, Paul Rodriguez, Guerrero Almeida, María de Lourdes, Powers, John H., Beigel, John H., Hunsberger, Sally, Trujillo, Karina, Ramos, Pilar, Arteaga-Cabello, Fernando J., López-Roblero, Alexander, Valdés-Salgado, Raydel, Arroyo-Figueroa, Hugo, Becerril, Eli, Ruiz-Palacios, Guillermo“…METHODS: Prospective, observational cohort evaluating the natural history of Zika virus infection in the Mexico-Guatemala border area. …”
Publicado 2021
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3380por Bettio, Cinzia, Salsi, Valentina, Orsini, Mirko, Calanchi, Enrico, Magnotta, Luca, Gagliardelli, Luca, Kinoshita, June, Bergamaschi, Sonia, Tupler, Rossella“…The tools used to collect, integrate, and visualize clinical, molecular and natural history information about patients affected by FSHD and their relatives are described. …”
Publicado 2021
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