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  1. 3621
    “…Although new data have better defined the complex etiology underling the interrelation of genetic and environmental factors in the natural history of T1D, relevant pieces of the puzzle still are missing. …”
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  2. 3622
    “…Its pathogenesis and natural history are not fully understood, and its management remains controversial. …”
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  3. 3623
    Publicado 2019
    “…Scientists at the meeting underscored the importance of studying the temporal natural history of exposures that may cumulatively impact cancer risk later in life. …”
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  4. 3624
    “…Characterizing additional individuals with diverse mutations longitudinally will provide better natural history data to assist with medical management and educational and behavioral support.…”
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  5. 3625
  6. 3626
    “…Despite that, surprisingly, little is known about their ecology, natural history and evolution. Most field studies on these parasites, performed from the 1940s to the early 1980s, showed that all rodent Plasmodium species infect only one main host species, the thicket rat. …”
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  7. 3627
    por Reid, Ian R
    Publicado 2019
    “…Studies have not been powered to assess whether clinically important endpoints such as fracture and the need for joint replacement surgery are diminished, although these complications are well established as part of the natural history of the condition. Since disease progression is prevented by potent bisphosphonates, it is likely that disease complications will also be prevented. …”
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  8. 3628
    “…Inflammatory bowel diseases (IBD), Crohn`s disease and ulcerative colitis, are chronic conditions associated with high morbidity and healthcare costs. The natural history of IBD is variable and marked by alternating periods of flare and remission. …”
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  9. 3629
    “…PREMISE: The digitization of natural history collections includes transcribing specimen label data into standardized formats. …”
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  10. 3630
    “…Limited data on the natural history of aHUS along with the underlying genetic mutations make it difficult to predict the relapses and thereby raising concerns about the appropriate duration and monitoring of treatment. …”
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  11. 3631
    por Koshiyama, Masafumi
    Publicado 2019
    “…These antioxidants may have different abilities to intervene in the natural history of diseases associated with HPV infection. …”
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  12. 3632
    “…Coronary angiography remains the gold standard tool, providing information about the size, shape, and location and is also useful for planning the strategy of surgical resection. The natural history and prognosis remain unclear. Despite the important anatomical abnormality of the coronary artery, the treatment options of coronary artery aneuryms are still poorly defined and present a therapeutic challenge. …”
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  13. 3633
    “…DISCUSSION & CONCLUSION: The treatment strategy should be tailored to the individual patient, the clinical presentation, and the rate of progression of the tumor. The natural history of the disease is still poorly understood and there is no uniform treatment form for such tumors.…”
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  14. 3634
  15. 3635
    “…This case highlights the necessity for a better understanding of the etiology, chronology, and natural history of atypical lymphoid proliferations.…”
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  16. 3636
    “…The true prevalence is not fully known due to its elusive presentation, being often under-recognized and usually diagnosed only late in its natural history and in older patients. Because of this, effective treatment options are usually precluded by multiple comorbidities and frailty associated with such patients. …”
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  17. 3637
    “…Because of its rarity, the characteristics, natural history, and long-term outcomes of QAV are poorly defined.…”
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  18. 3638
    “…Pediatric NAFLD has several unique aspects that distinguish it from the adult disease in terms of histology, our understanding of the natural history, and the utility of noninvasive tests. …”
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  19. 3639
    “…It is not clear whether there is a clinically important benefit to treating acute CSC, which often resolves spontaneously as part of its natural history. Of the interventions studied to date, PDT and micropulse laser treatment appear the most promising. …”
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  20. 3640
    por Mahmoud, Osama, Mehra, Vishal
    Publicado 2019
    “…We describe two rare complications as well as their natural history and uncertainties of the ideal management approach. …”
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