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  1. 3721
    por Davison, James E.
    Publicado 2020
    “…Disease-modifying treatment with enzyme replacement therapy has partially altered the natural history of the disease, but more efficacious novel therapies are under evaluation including second-generation enzyme replacement therapies, molecular chaperones and gene therapy approaches. …”
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    Advances in Diagnosis and Management of Pompe Disease
  2. 3722
    “…Understanding the natural history of stroke recovery, and adapting a multidisciplinary approach, will lead to improved chances for successful rehabilitation. …”
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    Overview of Acute Ischemic Stroke Evaluation and Management
  3. 3723
    “…Aside from established liver injury, various extrahepatic metabolic disorders impact the natural history of the disease, clinical outcomes, and the efficacy of antiviral therapy. …”
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    The Impact of Steatosis on Chronic Hepatitis C Progression and Response to Antiviral Treatments
  4. 3724
    “…This study compared these data with those of Wuhan and estimated the natural history of disease across the infected population and the time lag. …”
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    Graphical Trajectory Comparison to Identify Errors in Data of COVID-19: A Cross-Country Analysis
  5. 3725
    “…The clinical significance of ground-glass nodules (GGNs) has been investigated in extensive clinical research for many years. The natural history of GGNs is known to be closely related to their size, proportion of solid components, and size progression over time. …”
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    Guidelines for the Investigation and Management of Ground Glass Nodules
  6. 3726
    “…Furthermore, noninvasive tests that accurately predict disease progression as part of the natural history of NASH or regression in response to treatment are urgently needed to decrease the reliance on repeat liver biopsies. …”
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    What Does the Future Hold for Patients With Nonalcoholic Steatohepatitis: Diagnostic Strategies and Treatment Options in 2021 and Beyond?
  7. 3727
    por Armstrong, Terri S, Gilbert, Mark R
    Publicado 2021
    “…Similar limitations in preclinical models and in the understanding the natural history of the disease or pertinent prognostic factors further impede the development of hypothesis-based, appropriately powered clinical trials. …”
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    Clinical trial challenges, design considerations, and outcome measures in rare CNS tumors
  8. 3728
    por Roth, William, Mohamadzadeh, Mansour
    Publicado 2021
    “…In this review, we discuss the complex interactions of VB12, gut microbes and the associated metabolites, and immune homeostasis throughout the natural history of ischemic stroke.…”
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    Vitamin B12 and gut-brain homeostasis in the pathophysiology of ischemic stroke
  9. 3729
    “…As the case rate presumably increases over time, this review will inform measurements to determine the natural history and causal determinants of reinfection in more rigorous observational cohort studies and other standardized surveillance approaches.…”
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    Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection Cases Corroborated by Sequencing
  10. 3730
    “…No evidence of malignant changes has been reported and no hereditary transmission or environmental factor has been incriminated as an etiological factor. The natural history of the disease is continuous growth of the lesions until skeletal maturity. …”
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    Dysplasia Epiphysealis Hemimelica (Trevor’s Disease) in Children, Two New Cases: Diagnosis, Treatment, and Literature Review
  11. 3731
    “…There are few reports in the world medical literature about its etiology, presenting features, and catastrophic consequences. The natural history of the disease has not been well-defined yet. …”
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    Posttraumatic Pseudoaneurysm of Extracranial Internal Carotid Artery Presenting as Massive Oropharyngeal Bleed with Shock and Hemiparesis in a 12-year-old Boy: A Case Report
  12. 3732
    por Guleria, Prerna, Jain, Deepali
    Publicado 2019
    “…All lesions both non-neoplastic as well as neoplastic are found in children, however, they differ from adults not only in the clinical presentation but also in the pathogenesis and natural history of the disease. Thymic hyperplasia may not actually be true if age is taken into consideration. …”
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    Thymic lesions of the paediatric age group: a comprehensive review of non-neoplastic and neoplastic etiologies
  13. 3733
    “…Metastatic breast cancer has a longer natural history than many other common metastatic solid tumors. …”
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    Palliative care access in the elderly metastatic breast cancer population: obstacles and opportunities
  14. 3734
    “…According to the researches conducted during the nearly 40 years, it has been found that this bacterium is associated with a natural history of many upper gastrointestinal diseases. …”
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    Helicobacter Pylori and Autoimmune Diseases: Involving Multiple Systems
  15. 3735
    “…He was initially treated with a combination treatment of partial resection, radiation, and proposed oral imatinib, none of which modified the natural history and progression of his illness. Instead, these methods were performed as palliative measures to reduce the current size of the tumors and decrease growth rates to minimize his pain. …”
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    Metastatic Clivus Chordoma: A Case of a Rare Tumor in a 29-Year-Old African American Male
  16. 3736
    por Miller, David M, Shalhout, Sophia Z
    Publicado 2022
    “…OBJECTIVES: Structured real-world data (RWD), such as those found in cancer registries, provide a rich source of information regarding the natural history of cancer. Interactive data visualizations of cancer lesions can provide insights into certain clinical tumor characteristics (CTC). …”
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    BodyMapR: an R package and Shiny application designed to generate anatomical visualizations of cancer lesions
  17. 3737
    “…Further, there is speculation that gastric SRCC may have an indolent phase prior to symptomatic disease, but its natural history is essentially entirely unknown. In this case report, we describe a 39-year-old male with an incidentally discovered gastric SRCC who then underwent multimodality treatment with curative intent. …”
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    Gastric Signet-Ring-Cell Adenocarcinoma with Delayed Retroperitoneal Metastasis and Fibrosis
  18. 3738
    “…Since most thyroid nodules (TNs) are benign, and malignant neoplasms are characterized by an indolent natural history, it is generally safe to delay diagnostic and therapeutic procedures. …”
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    Updated clinical management guidance during the COVID-19 pandemic: thyroid nodules and cancer
  19. 3739
    “…The male-to-female proportion in a population is expressed as sex ratio and varies eminently with respect to the pathophysiology, natural history, incidence, prevalence, and mortality rates. …”
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    Hormones and Sex-Specific Medicine in Human Physiopathology
  20. 3740
    “…Delivery of hepatitis C virus (HCV)-contaminated blood products in the 70s (before HCV was identified) have dramatically increased our understanding of the natural history of HCV infection and the role that host immunity plays in the outcome to viral infection. …”
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    Uncovering Resistance to Hepatitis C Virus Infection: Scientific Contributions and Unanswered Questions in the Irish Anti-D Cohort
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