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  1. 3741
    “…Some primary immune defects are due to hyperactive pathways that can be targeted by specific inhibitors, providing innovative precision treatments that can change the natural history of diseases. In this article we review some of these “druggable” inborn errors of immunity and describe how they can be suspected and diagnosed in diverse pediatric and adult medicine specialties. …”
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    Druggable monogenic immune defects hidden in diverse medical specialties: Focus on overlap syndromes
  2. 3742
    “…Nasopharyngeal carcinoma (NPC) is distinct from other cancers of the head and neck in biology, epidemiology, histology, natural history, and response to treatment. Radiotherapy (RT) is the cornerstone of locoregional treatment of non-disseminated disease and the association of chemotherapy improves the rates of survival. …”
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    SEOM-TTCC clinical guideline in nasopharynx cancer (2021)
  3. 3743
    “…Because of the rarity of these tumors and the unpredictable natural history of the disease, well-defined and precise guidelines of the optimal treatment for DF have not been formulated. …”
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    Surgical Management of a Giant Desmoid Fibromatosis of Abdominal Wall With Vessels Invasion in a Young Man: A Case Report and Review of the Literature
  4. 3744
    “…Genetic testing of the peripheral blood revealed the presence of a pathogenic variant in MAX. The natural history of adrenal PCCs with the MAX variant has not yet been clarified, because the number of reported cases is not sufficient. …”
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    Bilateral Pheochromocytoma with Germline MAX Variant without Family History
  5. 3745
    “…Additionally, many factors are thought to influence the response to the stressor, and hence reshape the natural history and course of the disease. With sufficient knowledge about the disease, preventive and intervenient methods can be implemented to improve the quality of life of the patients and to limit both the medical and economic burden of the disease. …”
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    A Public Health Perspective of Post-Traumatic Stress Disorder
  6. 3746
    “…This review summarizes the incidence and diagnostic criteria for THV thrombosis and discusses the pathophysiological mechanisms that may lead to thrombus formation, its natural history, potential clinical implications and treatment for these patients.…”
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    Leaflet immobility and thrombosis in transcatheter aortic valve replacement
  7. 3747
    “…This review is to shed light on the natural history, pathology, molecular biology, and efficient diagnostic methods of COVID-19, detecting SARS-CoV-2 in collected samples. …”
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    COVID-19 Diagnosis: A Comprehensive Review of the RT-qPCR Method for Detection of SARS-CoV-2
  8. 3748
    “…Because of their purported benign natural history, PAMs are often conservatively managed. …”
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    Endovascular treatment of a ruptured posterior fossa pure arterial malformation: illustrative case
  9. 3749
    “…An understanding of isolated spinal artery aneurysm natural history, diagnosis, and management is evolving as more cases are identified. …”
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    Posterior spinal artery aneurysm as an unlikely culprit for perimesencephalic pattern subarachnoid hemorrhage: illustrative case
  10. 3750
    “…Furthermore it reflects the complexity of the pathophysiology and the uncertain natural history of syringomyelia.…”
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    Syringomyelia intermittens: highlighting the complex pathophysiology of syringomyelia. Illustrative case
  11. 3751
    “…The aim of this review is to discuss the recent literature on the main role of inflammation in the natural history of CD, supported by cellular fragility with increased sensitivity to gluten and other pro-inflammatory agents.…”
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    Pivotal Role of Inflammation in Celiac Disease
  12. 3752
    “…Given the complexity of signalling and diagnosing dementia, dedicated studies are required to unravel the natural history of dementia in this population.…”
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    The neglected puzzle of dementia in people with severe/profound intellectual disabilities: A systematic literature review of observable symptoms
  13. 3753
    por Wang, Yiheng, Yu, Jinlu
    Publicado 2022
    “…Therefore, we performed a review of the literature from a PubMed search and cataloged our experience regarding the classification and natural history of VBD and the prospects, prognosis and complications of EVT. …”
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    Prospects and Dilemmas of Endovascular Treatment for Vertebrobasilar Dolichoectasia
  14. 3754
    “…These data illustrate the natural history of dimensions of ACEs and their potential social patterning.…”
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    Prevalence of Adverse Childhood Experiences in the First Decade of Life: A Study in the Portuguese Cohort, Generation XXI
  15. 3755
    “…The natural history of MECP2 duplication syndrome (MDS), a rare X-linked neurodevelopmental disorder with an estimated birth prevalence of 1/150,000 live births, is poorly understood due to a lack of clinical data collected for research. …”
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    Development of an International Database for a Rare Genetic Disorder: The MECP2 Duplication Database (MDBase)
  16. 3756
    “…By reporting this case, we emphasize that HT changes the natural history and significantly affects the overall survival of patients with MZL. …”
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    Splenic Marginal Zone Lymphoma With Histological Transformation to Hodgkin’s Lymphoma
  17. 3757
    “…The species is known from only a single confirmed specimen–the 150-year-old holotype material housed at the London Natural History Museum. Using Laser-Doppler Vibrometry, 3D surface scanning microscopy, and known scaling relationships, it is shown that P. obscura produces a pure-tone song at a frequency of ~4.7 kHz. …”
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    Reviving the sound of a 150-year-old insect: The bioacoustics of Prophalangopsis obscura (Ensifera: Hagloidea)
  18. 3758
    por Astrup, Jens, Gyntelberg, Finn
    Publicado 2022
    “…The natural history and clinical course of tension-type headache and non-specific low back pain are reconsidered. …”
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    Tension-type headache and low back pain reconsidered
  19. 3759
    “…Due to their small target populations, leading to challenges regarding clinical trial recruitment, study design and little knowledge on the natural history of the disease, the overall clinical evidence submitted at the time of marketing authorisation application for these medicines is often limited. …”
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    Contribution of patient registries to regulatory decision making on rare diseases medicinal products in Europe
  20. 3760
    “…In this review, we first describe the natural history of LADA. Thereafter, we summarize β-cell function-related heterogeneous factors in LADA, including the age of onset, body mass index, genetic background, and immune, lifestyle, and environmental factors. …”
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    Latent autoimmune diabetes in adults: a focus on β-cell protection and therapy
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