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  1. 3921
    “…A deregulated leukocyte/mural cell interaction is an early critical event in the natural history of systemic inflammation. Despite intense efforts, the signals that initiate and sustain the immune-mediated vessel injury, or those that enforce the often-prolonged phases of clinical quiescence in patients with vasculitis, have only been partially elucidated. …”
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    Disruption of a Regulatory Network Consisting of Neutrophils and Platelets Fosters Persisting Inflammation in Rheumatic Diseases
  2. 3922
    “…These results illuminate the natural history of cancer evolution, indicating that tumor heterogeneity represents a significant obstacle to cancer control.…”
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    Pan-cancer analysis of intratumor heterogeneity as a prognostic determinant of survival
  3. 3923
    “…METHODS: 310 cGVHD patients enrolled in the NIH cGVHD natural history study (clinicaltrials.gov: NCT00092235) were analyzed. …”
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    Vitamin D levels and their associations with survival and major disease outcomes in a large cohort of patients with chronic graft-vs-host disease
  4. 3924
    “…Finally, the presence of the labial and epipharyngeal sclerites are reported as new characters of Nerioidea. Natural history data are provided.…”
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    Morphology and development rate of the immature stages of Glyphidops (Oncopsia) flavifrons (Bigot, 1886) (Diptera, Neriidae) under natural conditions
  5. 3925
    “…Here we delineate the natural history of metastasis in an autochthonous model of pancreatic ductal adenocarcinoma (PDAC), using lineage tracing to examine the evolution of disseminated cancer cells and their associated microenvironment. …”
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    Metastatic progression is associated with dynamic changes in the local microenvironment
  6. 3926
    “…More studies are needed to confirm the paramphistome species present in Savannakhet and its hosts to clear the natural history of these parasites of ruminants in the region and measure the impact of this parasite infection in the life and health of the local people.…”
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    First Record of Paramphistomes Fischoederius cobboldi and Paramphistomum epiclitum Detected in Bovine Rumen from a Local Market of Savannakhet Province, Lao PDR
  7. 3927
    “…The system strikingly resembles utilisation of bird nesting colonies by predators in other parts of the world but this spectacular system has never been described, emphasizing the continuing need for detailed natural-history studies in tropical Australia.…”
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    Communally Nesting Migratory Birds Create Ecological Hot-Spots in Tropical Australia
  8. 3928
    “…Extramedullary plasmacytoma is a not frequent manifestation during the natural history of multiple myeloma and is frequently associated with plasma cell bone marrow infiltration. …”
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    Extramedullary Plasmacytoma Mimicking Pancreatic Cancer: An Unusual Presentation
  9. 3929
    “…Zika virus (ZIKV), a typical example of a re‐emerging pathogen, recently caused large outbreaks in Pacific islands and the Americas, associated with congenital diseases and neurological complications. Deciphering the natural history, ecology and pathophysiology of this mosquito-borne pathogen requires effective reverse genetics tools. …”
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    Simple reverse genetics systems for Asian and African Zika viruses
  10. 3930
    “…From this review, we suggest that we need a study or number of studies that have the adequate power, epidemiological, and clinical data to provide a definitive conclusion on whether the effect of TTh on the natural history of CVD is real or not.…”
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    Testosterone replacement therapy and the heart: friend, foe or bystander?
  11. 3931
    “…Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma, which typically affects mature adults and elderly, whose median age at diagnosis is 65 years. The natural history of FL appears to have been favorably impacted by the introduction of Rituximab. …”
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    Follicular Lymphoma: The Management of Elderly Patient
  12. 3932
    “…It is suggested that the lack of knowledge regarding species in the genus Phalcoboenus may negatively affect the conservation status of these species, and believed that the lack of preference for certain research topics, such as systematics and natural history, are the result of historical factors including the decrease of field biology and perhaps a biased interest of the researchers. …”
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    A reassessment on the state of knowledge of Chilean Falconidae in the last hundred years
  13. 3933
    “…INTRODUCTION: Long-term natural history cohorts of HIV-1 in the absence of treatment provide the best measure of virulence by different viral subtypes. …”
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    Infecting HIV-1 Subtype Predicts Disease Progression in Women of Sub-Saharan Africa
  14. 3934
    “…The management and natural history are still poorly defined. Traditional medications for osteoporosis are calcium/vitamin D and bisphosphonate. …”
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    Pregnancy-related osteoporosis and spinal fractures
  15. 3935
    “…As standard drug treatment of allergic rhinitis (AR) is not completely satisfactory, allergen immunotherapy (AIT) represents the only current treatment with the potential to modify the natural history. House dust mite (HDM) allergy is very common. …”
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    Allergic rhinitis: the eligible candidate to mite immunotherapy in the real world
  16. 3936
    “…Although portal vein thrombosis and SRS are common occurrences in cirrhotic patients, the impact in the natural history of the disease is still unclear. Careful management and accurate imaging protocols are essential in the evaluation of those patients.…”
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    Giant Splenorenal Shunt in a Young Patient with Autoimmune Hepatitis/Primary Biliary Cholangitis Overlap Syndrome and Portal Vein Thrombosis
  17. 3937
    “…Though this number was too low for statistically valid correlations—a frequent problem in orphan diseases—we demonstrate the crucial role of the horizontally transferred transmembrane domain in developing cardiac and bone manifestations. Moreover, natural history suggests ageing as the principal determinant to develop skin and eye symptoms. …”
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    GGCX-Associated Phenotypes: An Overview in Search of Genotype-Phenotype Correlations
  18. 3938
    “…We provide an illustrated worker-based species identification key for all species found on Madagascar, as well as detailed taxonomic descriptions, which include diagnoses, discussions, measurements, natural history data, high-quality montage images and distribution maps for both new species. …”
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    X-Ray microtomography for ant taxonomy: An exploration and case study with two new Terataner (Hymenoptera, Formicidae, Myrmicinae) species from Madagascar
  19. 3939
    “…The current evidence supports an overall correlation between BML and patient symptoms, although literature findings are variable, and very little is known about the natural history and the progression of these lesions. …”
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    Aetiology and pathogenesis of bone marrow lesions and osteonecrosis of the knee
  20. 3940
    “…Ethnozoological knowledge pertaining to the natural history of M. pentadactyla is also reported from experienced Mro tribal hunters. …”
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    Pangolin distribution and conservation status in Bangladesh
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