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  1. 4061
    “…However, there is no doubt that the incorporation of PARP inhibitors as maintenance after the response to platinum-based chemotherapy, first in recurrent disease and recently also in first line, will change the natural history of the disease. The objective of this guide is to summarize the current evidence for the diagnosis, treatment, and follow-up of ovarian cancer, and to provide evidence-based recommendations for clinical practice.…”
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    SEOM clinical guideline in ovarian cancer (2020)
  2. 4062
    “…It is based on almost 400 collections, the great majority of which were collected by three of the co-authors over a period of 40 years and were lodged in the fungarium of the Natural History Museum in Copenhagen. The material was identified using molecular and morphological methods. …”
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    A survey of Hebeloma (Hymenogastraceae) in Greenland
  3. 4063
    “…Respiratory complications are the most common cause of death among patients with Myotonic Dystrophy type 1 (DM1), but the natural history of respiratory decline in DM1 patients is incompletely characterized and few predictors of the progression of respiratory dysfunction have been identified. …”
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    Factors Influencing the Severity and Progression of Respiratory Muscle Dysfunction in Myotonic Dystrophy Type 1
  4. 4064
    “…As orphan disease NBTs are now entering the clinical stage, substantial efforts are required to develop the scientific background and infrastructure for NBT design and mechanistic studies, genetic testing, understanding natural history of orphan disorders, data sharing, NBT manufacturing, and regulatory support. …”
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    Nucleic Acid–Based Therapeutics in Orphan Neurological Disorders: Recent Developments
  5. 4065
    “…In the last years, knowledge has substantially evolved on the pathophysiological mechanisms leading to cardiac damage, the natural history of cardiac manifestations, the late-onset phenotypes with predominant cardiac involvement, the early markers of cardiac damage, the role of multimodality cardiac imaging on the diagnosis, management and follow-up of Fabry patients, and the cardiac efficacy of available therapies. …”
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    Fabry Disease and the Heart: A Comprehensive Review
  6. 4066
    “…Records of the holdings at the Los Angeles County Museum of Natural History are summarized. Without material available north of Vancouver through Alaska, the range of G. oregonense could not be genetically verified. …”
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    Redescription of Gnorimosphaeroma oregonense (Dana, 1853) (Crustacea, Isopoda, Sphaeromatidae), designation of neotype, and 16S-rDNA molecular phylogeny of the north-eastern Pacific species
  7. 4067
    “…Further comprehension of the pathophysiology of the disease could lead to more efficacious specific therapeutic options, which could allow a change in the natural history of NS.…”
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    Netherton Syndrome in Children: Management and Future Perspectives
  8. 4068
    “…Furthermore, morphological data and natural history notes of the aforementioned species in Thailand have been provided, along with updated locations for the distribution of both species.…”
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    First national record of Gracixalus quangi Rowley, Dau, Nguyen, Cao & Nguyen, 2011 and G. yunnanensis Yu, Li, Wang, Rao, Wu &Yang, 2019 (Amphibia: Anura: Rhacophoridae) from Thailand
  9. 4069
    “…Our results report some of the first detection of diet items for the focal bat taxa, adding rich and novel natural history information to the field of bat ecology. …”
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    Molecular diet analysis of neotropical bats based on fecal DNA metabarcoding
  10. 4070
    “…Not only can these imaging modalities exclude other structural pathologies but they can also localise disease of the brachial plexus and outline the extent of disease and so allow the clinician to explore the natural history of immune-mediated brachial plexopathies. …”
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    Magnetic Resonance Neurography (MRN) of the Brachial Plexus: A Case of Parsonage Turner Syndrome and a Basic Review of Imaging of the Brachial Plexus
  11. 4071
    por van Trijp, Didi
    Publicado 2021
    “…It centres on the Historia piscium (Oxford, 1686), written by Francis Willughby and John Ray, and its surrounding sources. This natural history of fishes aspired to give a concise and precise overview of species, and to uncover the divine order in which they were created. …”
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    Fresh Fish: Observation up Close in Late Seventeenth-Century England
  12. 4072
    “…There are several scenarios in the natural history of the disease that must be considered based on adequate anamnesis with a clinical-epidemiological approach to determine the correct diagnostic category.…”
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    Laboratory-confirmed SARS-CoV-2 reinfection in the population treated at social security
  13. 4073
    “…We could confirm the associated phenotype as well as the natural history of this severe disease. By describing new presenting features, we are further expanding the clinical spectrum associated with Ogden syndrome and review other phenotypes associated with NAA10 variants.…”
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    Confirmation of Ogden syndrome as an X‐linked recessive fatal disorder due to a recurrent NAA10 variant and review of the literature
  14. 4074
    “…This article provides an overview of the current understanding of the role of SPSS in the natural history of liver cirrhosis and their status as a therapeutic target and an imaging biomarker to identify patients at higher risk of developing complications of PHT.…”
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    Friend or Foe? Spontaneous Portosystemic Shunts in Cirrhosis—Current Understanding and Future Prospects
  15. 4075
    “…Understanding the kinetics of viral editing rates in vivo is key to unravel the biology of the virus and understand its spread and natural history. We developed and validated a new assay based on next-generation sequencing and aimed at quantifying HDV RNA editing in plasma. …”
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    Variable In Vivo Hepatitis D Virus (HDV) RNA Editing Rates According to the HDV Genotype
  16. 4076
    “…However, it is also likely to be a consequence of the significant challenges faced by clinicians and researchers when designing trials for these disorders, which have historically been hampered by a lack of natural history data, biomarkers and outcome measures to detect a treatment effect. …”
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    Moving towards clinical trials for mitochondrial diseases
  17. 4077
    “…It is generally believed that hepatitis B virus (HBV) infected patients with normal ALT levels are in either immune tolerance or low replication stage of the natural history of hepatitis B, and there is no or only mild inflammation in liver tissue, so antiviral therapy is not recommended. …”
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    Antiviral Therapy for Chronic HBV Infection With Persistently Normal Alanine Aminotransferase: Controversy and Consensus
  18. 4078
    “…CONCLUSIONS: This is the first characterization of this type of tracheal tumor, including genomic findings, pathogenesis, and natural history.…”
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    High-Grade Neuroendocrine Carcinoma Within a Tracheal Polyp: A Case Report
  19. 4079
    “…Although in many patients the primary driver is metabolic dysfunction, a complex and dynamic interaction of different factors (i.e., sex, presence of one or more genetic variants, coexistence of different comorbidities, diverse microbiota composition, and various degrees of alcohol consumption among others) takes place to determine disease subphenotypes with distinct natural history and prognosis and, eventually, different response to therapy. …”
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    Insights into Nonalcoholic Fatty-Liver Disease Heterogeneity
  20. 4080
    “…This paper offers a comparative evaluation of the scientific impact of a citizen science program in ecology, ‘‘Vigie-Nature”, managed by the French National Museum of Natural History. Vigie-Nature consists of a national network of amateur observatories dedicated to a participative study of biodiversity in France that has been running for the last twenty years. …”
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    Measuring epistemic success of a biodiversity citizen science program: A citation study
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