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  1. 4141
    “…Our case also describes an unusual clinical course for ApHCM presenting with extreme clinical features, including ventricular arrhythmias and cardiac arrest, unlike the usual benign natural history of this disease.…”
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    Rare Occurrence of Apical Hypertrophic Cardiomyopathy Among Hispanics
  2. 4142
    “…Clinical management of prostate cancer is challenging because of its highly variable natural history and so there is a need for improved predictors of outcome in non-metastatic men at the time of diagnosis. …”
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    Combining Molecular Subtypes with Multivariable Clinical Models Has the Potential to Improve Prediction of Treatment Outcomes in Prostate Cancer at Diagnosis
  3. 4143
    “…Modern imaging techniques including SD-OCT, TD-OCT, SS-OCT, and OCTA assist with understanding the disease pathogenesis and natural history of disease progression, in addition to routine diagnosis and management in the clinical setting. …”
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    OCT and OCT Angiography Update: Clinical Application to Age-Related Macular Degeneration, Central Serous Chorioretinopathy, Macular Telangiectasia, and Diabetic Retinopathy
  4. 4144
    “…Little is known about the epidemiology, natural history, and transmission patterns of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant. …”
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    Transmission Dynamics and Epidemiological Characteristics of the SARS-CoV-2 Delta Variant ― Hunan Province, China, 2021
  5. 4145
    “…G4-DNA is also implicated in the control of transcription, and due to their impact on both CSR and transcriptional regulation, G4-rich sequences likely play a role in the natural history of B cell malignancies. Since G4-DNA stands at multiple locations in the genome, notably within oncogene promoters, it remains to be clarified how it can more specifically promote legitimate CSR in physiology, rather than pathogenic translocation. …”
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    Roles of G4-DNA and G4-RNA in Class Switch Recombination and Additional Regulations in B-Lymphocytes
  6. 4146
    “…Thus, it is necessary to identify the natural history of the disease and to establish promissory relations between the structure of a mathematical model, as well as its parameters, with control-related strategies (real interventions) and relevant socio-cultural behaviors. …”
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    A discrete model for the evaluation of public policies: The case of Colombia during the COVID-19 pandemic
  7. 4147
    “…The occurrence of CRT represents a major event in the natural history of patients in PN since it can lead to central venous access loss and PN failure. …”
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    Prevention and treatment of catheter-related venous thrombosis in long-term parenteral nutrition: A SINuC position statement
  8. 4148
    “…Various medical comorbidities are associated with the natural history of GBM. The most disabling and greatly affecting patients’ quality of life are neurodegeneration, cognitive impairment, and GBM-related epilepsy (GRE). …”
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    Antitumor Potential of Antiepileptic Drugs in Human Glioblastoma: Pharmacological Targets and Clinical Benefits
  9. 4149
    “…This work aimed to assess seven NLMEM approaches in the same framework: treatment effect assessment in balanced two-armed designs using real natural history data with or without the addition of simulated treatment effect. …”
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    Comparison of Seven Non-Linear Mixed Effect Model-Based Approaches to Test for Treatment Effect
  10. 4150
    “…PV isolation through CB is the most studied single-shot technique for atrial fibrillation ablation, having shown the potential to alter the natural history of the arrhythmia. Several procedural tips and tricks can improve procedural flow and effectiveness. …”
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    Best Practice Guide for Cryoballoon Ablation in Atrial Fibrillation: The Compilation Experience of More than 1000 Procedures
  11. 4151
    “…Common carotid artery occlusion (CCAO) is a relatively rare condition, and both its natural history and recommendations for treatment are still unclear. …”
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    Long-segment common carotid occlusion presenting with limb-shaking transient ischemic attack: Case report
  12. 4152
    Publicado 1960
    Seriadas
    Annals of the New York Academy of Sciences.
  13. 4153
    “…These advances offer opportunities to initiate newly proven treatments to enhance outcomes, alter the natural history, and envision the future of two diseases that have no known cure.…”
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    Advances in acute and chronic pancreatitis
  14. 4154
    “…The model performed well on simulated data relative to alternative approaches and produced reasonable empirical results given the natural history of clownfish. The resulting inferences provide important insights into the population genetic dynamics of spatially structure populations.…”
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    A spatial approach to jointly estimate Wright’s neighborhood size and long-term effective population size
  15. 4155
    “…These models are essential measures in studying the natural history of IDD and finding the possible therapeutic target against IDD. …”
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    Constructing intervertebral disc degeneration animal model: A review of current models
  16. 4156
    “…SIMPLE SUMMARY: Since the advent of trastuzumab in HER2-positive metastatic breast cancer management, the natural history of this disease continues to improve. …”
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    HER2-Positive Metastatic Breast Cancer: Available Treatments and Current Developments
  17. 4157
    “…A positive result of these trials will probably be the spark to test the hypothesis of the modification of AVC’s natural history with the novel Lp(a)-lowering agents.…”
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    Lipoprotein(a): Its Association with Calcific Aortic Valve Stenosis, the Emerging RNA-Related Treatments and the Hope for a New Era in “Treating” Aortic Valve Calcification
  18. 4158
    “…However, in the case of outbreaks of emerging infectious diseases with an unknown natural history or undetermined characteristics, the serial interval and/or contact tracing data are often not available, resulting in inaccurate estimates for this quantity. …”
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    A new method for the joint estimation of instantaneous reproductive number and serial interval during epidemics
  19. 4159
    “…New genomic techniques applied to degraded samples, such as those from natural history collections, can uncover the complex evolutionary consequences of human pressures and generate baselines for interpreting magnitudes of species loss or persistence relevant to conservation. …”
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    Historical DNA from a rediscovered nineteenth-century paratype reveals genetic continuity of a Bahamian hutia (Geocapromys ingrahami) population
  20. 4160
    “…Yet, the role of EBV infection in the natural history of MS and in the initiation of neurodegeneration is even less clear. …”
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    Epstein-Barr Virus and Multiple Sclerosis: A Convoluted Interaction and the Opportunity to Unravel Predictive Biomarkers
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