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  1. 4181
    “…We aimed to describe the natural history of patients relapsed or refractory (R/R) to CD38 MoAB therapy. …”
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    Clinical Outcomes of Patients with Multiple Myeloma after Daratumumab Failure
  2. 4182
    por Huang, Wei, Bai, Lang, Tang, Hong
    Publicado 2023
    “…This review first offers a description of the natural history of EBV infection, clarifies the interaction between EBV and the immune system, and finally focuses on several major types of diseases caused by EBV infection.…”
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    Epstein-Barr virus infection: the micro and macro worlds
  3. 4183
    “…After a course of steroids and intravenous nafcillin, the patient recovered without neurological deficits. LESSONS: The natural history of intrameningioma abscesses is not fully understood. …”
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    Intratumoral abscess complicating a postradiation-induced World Health Organization grade II meningioma: illustrative case
  4. 4184
    “…Surgical and interventional repair of thoracoabdominal aortic aneurysms improve survival significantly compared to the natural history of the disease. However, both strategies are associated with a substantial risk of spinal cord ischemia, which has been reported to occur—even in contemporary series by expert centers—in up to 12% of patients, depending on the extent of the disease. …”
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    Rationale of the PAPAartis trial
  5. 4185
    por Jellinger, Kurt A.
    Publicado 2023
    “…Cognitive reserve may moderate the effect of brain damage but is not protective against cognitive decline. The natural history of cognitive dysfunction in ALS and its relationship to FTD are not fully understood, although there is an overlap between the ALS variants and ALS-related frontotemporal syndromes, suggesting a differential vulnerability of motor and non-motor networks. …”
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    The Spectrum of Cognitive Dysfunction in Amyotrophic Lateral Sclerosis: An Update
  6. 4186
    “…Competition is an important biological filter that can define crucial features of species’ natural history, like survival and reproduction success. …”
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    Flowering Time Variation in Two Sympatric Tree Species Contributes to Avoid Competition for Pollinator Services
  7. 4187
    “…Such diagnostic innovations, along with the increased awareness by clinicians and patients due to the availability of alternative therapeutic approaches (laparoscopic and robotic Heller myotomy, and peroral endoscopic myotomy) have radically changed the natural history of the disorder. Herein, we report the most recent advances in the diagnosis, classification, and management of esophageal achalasia and underline the still-grey areas that needs to be addressed by future research to reach the goal of personalizing treatment.…”
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    Modern Achalasia: Diagnosis, Classification, and Treatment
  8. 4188
    “…Further research will explore the cancer burden, natural history, treatment patterns, and risk factors of the target cancers.…”
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    Integrated database-based Screening Cohort for Asian Nomadic descendants in China (Scan-China): Insights on prospective ethnicity-focused cancer screening
  9. 4189
    “…The interaction between genetic predisposition and other factors partially explains the large variability of NAFLD phenotype and natural history. Numerous genes and variants have been identified through large-scale genome-wide association studies (GWAS) that are associated with NAFLD and one or more subtypes of the disease. …”
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    Gene Variants Implicated in Steatotic Liver Disease: Opportunities for Diagnostics and Therapeutics
  10. 4190
    “…Disease-modifying treatments have transformed the natural history of spinal muscular atrophy (SMA), but the cellular pathways altered by SMN restoration remain undefined and biomarkers cannot yet precisely predict treatment response. …”
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    Cerebrospinal Fluid Proteomic Changes after Nusinersen in Patients with Spinal Muscular Atrophy
  11. 4191
    “…Here, we report a case of a woman affected by recurring LAR TNBC, which underwent phenotypic changes throughout its natural history. After the initial diagnosis of LAR breast cancer, the patient experienced local recurrence with strong expression of the estrogen receptor. …”
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    More Than Meets the Eye: A Case of Breast Cancer Switching from Being Luminal-Androgen-Receptor-Positive to Being Hormone-Receptor-Positive
  12. 4192
    “…Different dietary regimens, fiber intake, immunonutrients, and antioxidants have the potential to either exacerbate or mitigate chronic inflammation, thereby influencing the pathogenesis and natural history of PDAC. These dietary components may affect the gut microbiota composition and, consequently, the level of inflammation, either promoting or protecting against PDAC. …”
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    Pancreatic Ductal Adenocarcinoma and Nutrition: Exploring the Role of Diet and Gut Health
  13. 4193
    “…Future research should focus on improving diagnostic methods, illustrating underlying pathogenesis and biomarkers, and assessing long-term natural history. Increased knowledge and awareness for FPIES are required.…”
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    Diagnostic and Management Strategies of Food Protein-Induced Enterocolitis Syndrome: Current Perspectives
  14. 4194
    por Clark, William, Diamond, Terrence
    Publicado 2023
    “…Others showed no additional benefit from vertebroplasty compared to placebo when it was performed later in the natural history of the fracture. In this review, we examine data from blinded and open label randomised studies of vertebroplasty for evidence relating specifically to the use of early vertebroplasty for patients with severely painful acute osteoporotic fractures.…”
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    Early Vertebroplasty for Severely Painful Acute Osteoporotic Compression Fractures: A Critical Review of the Literature
  15. 4195
    “…Interest in the pathophysiology, etiology, management, and outcomes of patients with tricuspid regurgitation (TR) has grown in the wake of multiple natural history studies showing progressively worse outcomes associated with increasing TR severity, even after adjusting for multiple comorbidities. …”
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    Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints
  16. 4196
    “…It is expected that clinical and basic science studies will provide the clinician with new scientific information about the natural history and optimal treatment of OA at an early stage. …”
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    Quantitative ultrasonic assessment for detecting microscopic cartilage damage in osteoarthritis
  17. 4197
    “…In particular, hypothalamic and pituitary damage related to its natural history as well as treatment effects of craniopharyngiomas substantially affect life expectancy and quality of life. …”
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    Hypothalamic and Pituitary Dysfunction After Extensive Brain Surgery: There Is Thirst for More Knowledge
  18. 4198
    “…The natural history of short bowel syndrome involves intestinal adaptation wherein the remnant small intestine undergoes histologic and anatomic changes aimed at increasing absorption. …”
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    Gastric Foveolar Hyperplastic Polyps in 2 Children With Short Bowel Syndrome on Long-Term Teduglutide
  19. 4199
    por Zhou, Zibo, Lan, Wenjing, Yu, Jinlu
    Publicado 2023
    “…In this review, the following issues were discussed: MCA anatomy and anomalies, classifications of MCA aneurysms, the natural history of MCA aneurysms, EVT status and principle, deployments of traditional coiling techniques and flow diverters (FDs), and deployments and prospects of intrasaccular flow disruptors and stent-like devices. …”
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    Endovascular treatment of middle cerebral artery aneurysms: current status and future prospects
  20. 4200
    por Lu, Xuanyong, Block, Timothy
    Publicado 2004
    “…Despite considerable advances in the understanding of the natural history of HBV disease, most of the early steps in the virus life cycle remain unclear. …”
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    Study of the early steps of the Hepatitis B Virus life cycle
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