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  1. 4201
    “…The long-standing technology of ECG, with more than a century of existence, remains as the supplementary method with highest value in diagnosis, and currently new electrocardiographic criteria are suggested, which indicate high risk of VF. Natural history indicates a somber diagnosis in symptomatic patients with a high index of arrhythmic SCD secondary to very fast polymorphic ventricular tachycardia bursts, which degenerate into VF. …”
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    Brugada Disease: Chronology Of Discovery And Paternity. Preliminary Observations And Historical Aspects
  2. 4202
    “…Although PSE does not require assumptions about natural history of cancer it requires other assumptions, particularly progressive detection – the assumption that once a cancer is detected by a screening test, it will always be detected by the screening test. …”
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    Using observational data to estimate an upper bound on the reduction in cancer mortality due to periodic screening
  3. 4203
    “…In summary, our study has, for the first time, characterized the temporal and dynamic changes of humoral and CTL responses in the natural history of SARS-recovered individuals, and strongly supports the notion that high and sustainable levels of immune responses correlate strongly with the disease outcome. …”
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    Long-Term Persistence of Robust Antibody and Cytotoxic T Cell Responses in Recovered Patients Infected with SARS Coronavirus
  4. 4204
    “…Furthermore, until more cases of solid SMA are identified to further elucidate its natural history and improve the reliability of preoperative diagnosis, surgical resection of this solid pancreatic tumor should be considered standard therapy in order to exclude malignancy.…”
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    Solid serous microcystic adenoma of the pancreas
  5. 4205
    “…Risk factors for development of renal tubular dysfunction and osteodystrophy include platinum chemotherapy, increasing cumulative ifosfamide dose, and reduced nephron mass. The natural history of ifosfamide-induced renal damage is variable, dysfunction may not become apparent until some months after treatment, and may improve or worsen with time. …”
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    Osteomalacia as a Late Metabolic Complication of Ifosfamide Chemotherapy in Young Adults: Illustrative Cases and Review of the Literature
  6. 4206
    por Cook, G. A., Draper, G. J.
    Publicado 1984
    “…The extent of this effect cannot be quantified precisely because of uncertainties concerning the natural history of cervical cancer, differences in risk for different cohorts, and the possible effects of other factors. …”
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    Trends in cervical cancer and carcinoma in situ in Great Britain.
  7. 4207
    “…Such a trial would improve our knowledge of the natural history of the disease and might help to answer some questions raised recently regarding its biological heterogeneity.…”
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    Is neuroblastoma screening evaluation needed and feasible?
  8. 4208
    “…These differences were statistically significant (Mann-Whitney P < 0.05), suggesting that combined tumours may have a separate natural history. We, therefore, analysed all stage I patients managed with surveillance (530 in total) post orchidectomy. …”
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    An analysis of surveillance for stage I combined teratoma--seminoma of the testis.
  9. 4209
    “…BACKGROUND: We examine the epidemiology, natural history, and prognostic factors that affect the duration of survival for islet cell carcinoma by using population-based registries. …”
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    Population-Based Study of Islet Cell Carcinoma
  10. 4210
    “…Hepatitis C virus (HCV) infection occurs less frequently in children than in adult patients, and the natural history, prognosis, and clinical significance of HCV infection in children are poorly defined. …”
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    Hepatitis C virus infection acquired in childhood
  11. 4211
    “…Since the DCCT, the increased focus on good glycaemic control is changing the natural history of diabetic retinopathy. Based on this, the aim of this study was to investigate whether patients with type 1 diabetes treated entirely or mostly in the post-DCCT era and tested in the absence of confounding factors show retinal haemodynamic abnormalities. …”
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    Retinal haemodynamics in individuals with well-controlled type 1 diabetes
  12. 4212
    Publicado 1988
    “…These findings establish the use of labeled SAP as a noninvasive in vivo diagnostic probe in experimental amyloidosis, potentially capable of revealing the natural history of the condition, and suggest that it may also be applicable generally as a specific targeting agent for diagnostic and even therapeutic purposes in clinical amyloidosis.…”
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    Specific localization and imaging of amyloid deposits in vivo using 123I-labeled serum amyloid P component
  13. 4213
    por Abi-Rached, Laurent, Parham, Peter
    Publicado 2005
    “…To understand better activating KIR and their relationship to inhibitory KIR, we took the approach of reconstructing their natural history and that of Ly49, the analogous system in rodents. …”
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    Natural selection drives recurrent formation of activating killer cell immunoglobulin-like receptor and Ly49 from inhibitory homologues
  14. 4214
    “…BACKGROUND: Rapidly destructive arthrosis of the hip is a rare and incompletely understood disorder with scarce literature about variations in natural history within a population. METHODS: A series of cases from North Wales with rapid progressive joint destruction and extensive subchondral bone loss in the femoral head and acetabulum are presented. …”
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    Rapidly destructive osteoarthritis of the hip joint: a case series
  15. 4215
    “…Background and purpose: Brain metastasis is a relatively uncommon event in the natural history of soft tissue sarcomas. The increasing use of chemotherapy may have caused a reduction in local relapses as well as distant failures leading to an improvement in survival, thereby allowing metachronous seeding of the brain, a sanctuary site. …”
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    Brain Metastases in Soft Tissue Sarcomas: Case Report and Literature Review
  16. 4216
    “…We strongly lack information on the natural history of this complex disease and on what factors are involved in its evolution and its outcome. …”
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    French database of children and adolescents with Prader-Willi syndrome
  17. 4217
    por Agosti, Donat, Egloff, Willi
    Publicado 2009
    “…BACKGROUND: A large part of our knowledge on the world's species is recorded in the corpus of biodiversity literature with well over hundred million pages, and is represented in natural history collections estimated at 2 – 3 billion specimens. …”
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    Taxonomic information exchange and copyright: the Plazi approach
  18. 4218
    “…In 2004, the Pediatric Dengue Cohort Study was established in Managua, Nicaragua, to study the natural history and transmission of dengue in children. …”
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    The Nicaraguan Pediatric Dengue Cohort Study: Study Design, Methods, Use of Information Technology, and Extension to Other Infectious Diseases
  19. 4219
    “…Since the introduction of HAART, there was a remarkably change in the natural history of HIV disease, leading to a notable extension of life expectancy, although prolonged metabolic imbalances could significantly act on the longterm prognosis and outcome of HIV-infected persons, and there is an increasing concern about the cardiovascular risk in this population. …”
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    New Options in the Treatment of Lipid Disorders in HIV-Infected Patients
  20. 4220
    “…INTRODUCTION: Targeted therapies may impact the natural history of bladder cancer based upon their pharmacokinetics. …”
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    Carcinomatous meningitis in a patient with Her2/neu expressing bladder cancer following trastuzumab and chemotherapy: a case report and review of the literature
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