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  1. 4221
    “…RESEARCH DESIGN AND METHODS: We constructed a Markov model simulating individuals' movement across different BMI categories, the incidence of diabetes and screening, and the natural history of diabetes and its complications over the next 25 years. …”
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    Projecting the Future Diabetes Population Size and Related Costs for the U.S.
  2. 4222
    “…To characterize the natural history and define outcome measures for clinical trials, we assessed the clinical history, laboratory findings and muscle strength and function in 57 patients with genetically confirmed disease. …”
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    Clinical features of spinal and bulbar muscular atrophy
  3. 4223
    “…While previous work has addressed the mathematical description of TB natural history, the impact of demography on the behaviour of TB models has not been assessed. …”
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    The Impact of Realistic Age Structure in Simple Models of Tuberculosis Transmission
  4. 4224
    “…METHODS: The model represents the natural history of EAC, including the essential biologic health states from normal mucosa to detected cancer. …”
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    Development, Calibration, and Validation of a U.S. White Male Population-Based Simulation Model of Esophageal Adenocarcinoma
  5. 4225
    “…Undifferentiated connective tissue disease (UCTD) is a distinct clinical entity that may be accompanied by interstitial lung disease (ILD). The natural history of UCTD-ILD is unknown. We hypothesized that patients with UCTD-ILD would be more likely to have improvement in lung function than those with idiopathic pulmonary fibrosis (IPF) during longitudinal follow-up. …”
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    Undifferentiated Connective Tissue Disease-Associated Interstitial Lung Disease: Changes in Lung Function
  6. 4226
    “…The cause for an increased incidence of pediatric gallstones and their natural history need to be further evaluated.…”
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    Pediatric cholelithiasis and laparoscopic management: A review of twenty two cases
  7. 4227
    “…The cause for increased incidence of pediatric gallstones and their natural history needs to be further evaluated.…”
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    Laparoscopic cholecystectomy for cholelithiasis in children
  8. 4228
    “…We are unaware of any previous reports suggesting such a prolonged natural history of hepatic angiosarcoma. This case may represent the possibility of malignant transformation of a lower grade vascular neoplasm such as hepatic epithelioid hemangioendothelioma to an angiosarcoma.…”
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    Hepatic angiosarcoma five years following spontaneous intraperitoneal bleed of a hepatic mass
  9. 4229
    “…The results of this study suggest that bracing is effective in reducing the incidence of surgery in comparison with natural history.…”
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    Effectiveness of Chêneau brace treatment for idiopathic scoliosis: prospective study in 79 patients followed to skeletal maturity
  10. 4230
    “…The importance of these periods of rapid decline may have been under-appreciated in prior studies of the natural history of CKD and ESRD.…”
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    End-stage renal disease preceded by rapid declines in kidney function: a case series
  11. 4231
    “…The role in this setting and natural history of hepatitis E in HIV-infected patients are unknown. …”
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    Hepatitis E Virus infection in HIV-infected patients with elevated serum transaminases levels
  12. 4232
    por Bukowski, Ronald M
    Publicado 2011
    “…Current therapeutic approaches for the management of patients with metastatic RCC utilize knowledge of histology, molecular abnormalities, clinical prognostic factors, the natural history of this malignancy, and the treatment efficacy and toxicity of available agents. …”
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    Critical appraisal of pazopanib as treatment for patients with advanced metastatic renal cell carcinoma
  13. 4233
    “…Background/Aims: Spontaneous acute exacerbation of chronic hepatitis B virus (HBV) infection occasionally occurs in its natural history, sometimes leading rapidly to fatal hepatic failure. …”
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    Efficacy of Lamivudine or Entecavir on Acute Exacerbation of Chronic Hepatitis B
  14. 4234
    por Chomel, Jean-Claude, Turhan, Ali G.
    Publicado 2011
    “…Targeted therapies of chronic myeloid leukemia (CML) using tyrosine kinase inhibitors (TKI) have profoundly changed the natural history of the disease with a major impact on survival. …”
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    Chronic myeloid leukemia stem cells in the era of targeted therapies: resistance, persistence and long-term dormancy
  15. 4235
    “…A complex interplay between the functional impact of the mutations on p53 phenotype and the cancer natural history may affect these patterns. However, our results strongly support that genotoxins exposure plays a major role in the aetiology of the considered cancers.…”
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    Benzo[a]pyrene, Aflatoxine B(1) and Acetaldehyde Mutational Patterns in TP53 Gene Using a Functional Assay: Relevance to Human Cancer Aetiology
  16. 4236
    “…This community-based study reports the epidemiology and the natural history of the infection from an affected village. …”
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    Epidemiology, Clinical Manifestations, and Long-Term Outcomes of a Major Outbreak of Chikungunya in a Hamlet in Sri Lanka, in 2007: A Longitudinal Cohort Study
  17. 4237
    “…BACKGROUND: The aims of this study were to identify that the differences in the natural history of patients with symptomatic and asymptomatic carotid stenosis may be reflected in differences in the expression of procoagulant protein factors. …”
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    Tissue Factor Expression in the Symptomatic Carotid Plaque
  18. 4238
    “…Our study showed, for the first time, that the analyzed polymorphisms of VRD may exert an effect on a natural history of PBC.…”
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    Vitamin D Receptor Polymorphisms Predispose to Primary Biliary Cirrhosis and Severity of the Disease in Polish Population
  19. 4239
    “…Further field studies with non-invasive methods are needed to determine the prevalence, geographic distribution, species association, and natural history of SIVcpz strains in the chimpanzee habitat in Gabon.…”
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    New Strain of Simian Immunodeficiency Virus Identified in Wild-Born Chimpanzees from Central Africa
  20. 4240
    “…In contrast, we show that sample size estimates for clinical trials aimed at the preclinical stage of the disorder (HCs with evidence of AD pathology) are prohibitively large. Longer natural history studies are needed to inform design of trials aimed at the presymptomatic stage.…”
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    Enrichment and Stratification for Predementia Alzheimer Disease Clinical Trials
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