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  1. 4261
    “…Prospective data regarding the natural history and sequelae of microbleeds are currently limited, however there is a growing evidence base that will serve to inform clinical decision-making in the future.…”
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    Cerebral Microbleeds: A Review of Clinical, Genetic, and Neuroimaging Associations
  2. 4262
    “…METHODOLOGY/PRINCIPAL FINDINGS: We developed a parsimonious age-structured model describing the natural history and immunity to typhoid infection. The model was fit to data on culture-confirmed cases of typhoid fever presenting to Christian Medical College hospital in Vellore, India from 2000–2012. …”
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    Predicting the Impact of Vaccination on the Transmission Dynamics of Typhoid in South Asia: A Mathematical Modeling Study
  3. 4263
    “…The present article discusses the justification of HPV vaccination in the backdrop of natural history of cervical cancer, the mechanism of action of the vaccines, efficacy and safety data from phase III randomized controlled trials as well as from the national immunization programs of various countries.…”
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    Efficacy and safety of human papillomavirus vaccine for primary prevention of cervical cancer: A review of evidence from phase III trials and national programs
  4. 4264
    “…Objective The objective of this study is to describe the natural history of neurologic recovery after anterior cervical discectomy and fusion (ACDF). …”
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    Neurologic Recovery after Anterior Cervical Discectomy and Fusion
  5. 4265
    “…We hypothesize that chum salmon natural history makes them less vulnerable to negative impacts from hatchery supplementation.…”
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    Genetic assessment of a summer chum salmon metapopulation in recovery
  6. 4266
    “…This is the first once-daily combination of ultra-long-acting inhaled β(2)-agonists and inhaled glucocorticoids that is available for the treatment of stable COPD and has great potential to improve compliance to long-term regular inhaled therapy and hence to improve the natural history and prognosis of COPD patients.…”
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    Profile of fluticasone furoate/vilanterol dry powder inhaler combination therapy as a potential treatment for COPD
  7. 4267
    “…Improved antigenic characterization of additional ORFs may increase the sensitivity of serologic assays, lead to more rapid progresses in understanding immune responses to KSHV, and allow for better comprehension of the natural history of KSHV infection. To this end, we have developed a bead-based multiplex assay detecting antibodies to six KSHV antigens.…”
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    Heterogeneity and Breadth of Host Antibody Response to KSHV Infection Demonstrated by Systematic Analysis of the KSHV Proteome
  8. 4268
    “…BACKGROUND: Granulosa cell tumors are rare neoplasms characterized by long natural history and favorable prognosis. AIMS: The objective of this study was to determine the clinical presentation, treatment, outcome, and prognostic factors for patients of granulosa cell tumors. …”
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    Ovarian Granulosa Cell Tumor: Clinical Features, Treatment, Outcome, and Prognostic Factors
  9. 4269
    “…In fact, most tumor dynamics are predicted to be in the evolutionarily transient regime throughout their natural history, so that clinically, the ESS is often largely irrelevant. …”
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    Evolution of Proliferation and the Angiogenic Switch in Tumors with High Clonal Diversity
  10. 4270
    “…CONCLUSION: Bone metastases often have a pejorative turning in the natural history of differentiated thyroid cancers. The right selection of individuals with better prognosis, for whom more aggressive curative treatment was indicated, requires a better understanding of the features of bone involvement.…”
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    Clinical features of bone metastasis for differentiated thyroid carcinoma: A study of 21 patients from a Tunisian center
  11. 4271
    “…Background. The natural history of traumatic aneurysms of the middle meningeal artery (MMA) is not well known, but patients with these lesions are more likely to have delayed bleeds. …”
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    Computed Tomography Angiography for Detection of Middle Meningeal Artery Lesions Associated with Acute Epidural Hematomas
  12. 4272
    “…METHODOLOGY/PRINCIPAL FINDINGS: A Markov decision model was constructed to simulate the natural history of a Chagas disease cohort in Mexico and to project the associated short and long-term clinical outcomes and corresponding costs. …”
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    Opportunity Cost for Early Treatment of Chagas Disease in Mexico
  13. 4273
    “…These differences provide a global view of physiopathologic processes active in the asthmatic lung and may provide invaluable help to clarify the natural history of asthma.…”
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    Functional classes of bronchial mucosa genes that are differentially expressed in asthma
  14. 4274
    “…Longitudinal follow-up studies, unfortunately still insufficient, are needed to better understand the natural history and outcome of NAFLD in children. This review focuses on the current knowledge regarding the epidemiology, pathogenesis, environmental, genetic and metabolic factors of disease. …”
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    Nonalcoholic Fatty Liver Disease/Non-Alcoholic Steatohepatitis in Childhood: Endocrine-Metabolic “Mal-Programming”
  15. 4275
    “…The preservation of species requires not only detailed knowledge of their natural history and genetic structure but also information on the availability of suitable areas where species can survive, and such knowledge can aid significantly in conservation planning. …”
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    Genetic Pool Information Reflects Highly Suitable Areas: The Case of Two Parapatric Endangered Species of Tuco-tucos (Rodentia: Ctenomiydae)
  16. 4276
    “…Background. The natural history of gallstone formation after laparoscopic sleeve gastrectomy (LSG), the incidence of symptomatic gallstones, and timing of cholecystectomy are not well established. …”
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    Complicated Gallstones after Laparoscopic Sleeve Gastrectomy
  17. 4277
    “…Close clinical and radiological follow-up is recommended in this case because the natural history of the disease is unclear at this point. …”
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    Diffuse idiopathic intracranial fusiform aneurysm development. Case report and literature review
  18. 4278
    “…The IPT’s two primary functions are to 1) encode existing species occurrence datasets and checklists, such as records from natural history collections or observations, in the Darwin Core standard to enhance interoperability of data, and 2) publish and archive data and metadata for broad use in a Darwin Core Archive, a set of files following a standard format. …”
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    The GBIF Integrated Publishing Toolkit: Facilitating the Efficient Publishing of Biodiversity Data on the Internet
  19. 4279
    “…RESULTS: Multiple socio-demographic and potential risk factors have been recognized in the causation and determining the long-term outcomes of the disease world-wide. As the natural history of hypertension is complex and etiology is multi-factorial the strategy to combat also should be multi-pronged based on the trends and magnitude of the disease in variable settings. …”
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    The Determinants and Scope of Public Health Interventions to Tackle the Global Problem of Hypertension
  20. 4280
    “…With good knowledge of the regional anatomy and meticulous microsurgical techniques, there is a low mortality and minimum morbidity, when compared to the natural history of the disease. With increasing experience, most of the complications are avoidable. …”
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    Complication avoidance in transcallosal transforaminal approach to colloid cysts of the anterior third ventriclen: An analysis of 80 cases
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