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  1. 4321
    “…Finally, these observations emphasize those effective therapies for these disorders must be given early in the natural history of the disease, prior to the development of tissue remodelling and fibrosis.…”
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    Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis
  2. 4322
    por Swanson, Eric
    Publicado 2016
    “…Only by using a reliable diagnostic tool such as Doppler ultrasound are we able to learn more about the natural history of this problem in our patients. Such knowledge is likely to better inform our treatment recommendations.…”
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    Caprini Scores, Risk Stratification, and Rivaroxaban in Plastic Surgery: Time to Reconsider Our Strategy
  3. 4323
    “…We propose that impaired mitochondrial function marks the progression from metabolic inflexibility to dedifferentiation in the natural history of β-cell failure.…”
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    Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice
  4. 4324
    “…Background. The natural history of idiopathic pulmonary fibrosis (IPF) is very complex and unpredictable. …”
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    Plasma Leptin Is Elevated in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
  5. 4325
    “…Little is known about their natural history, especially about their acoustic communication. …”
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    Redescription of the Advertisement Call of Five Species of Thoropa (Anura, Cycloramphidae), Including Recordings of Rare and Endangered Species
  6. 4326
    por Shah, M V, Hook, C C, Call, T G, Go, R S
    Publicado 2016
    “…We present clinical characteristics, natural history and risk factors for poor survival in patients with LGL leukemia using the Surveillance, Epidemiology, and End Results Program (SEER) and the United States National Cancer Data Base (NCDB). …”
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    A population-based study of large granular lymphocyte leukemia
  7. 4327
    “…Review of the large Smithsonian collection (National Museum of Natural History, Washington) revealed the presence of two morphologically extraordinary undescribed species and added a new record to the north-western Atlantic region. …”
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    Sphaerodoridae (Annelida) of the deep Northwestern Atlantic, including remarkable new species of Euritmia and Sphaerephesia
  8. 4328
    “…The main topics discussed at this meeting were: Molecular and Immuno advances, Immunotherapies and Combination Therapies, Tumor Microenvironment and Biomarkers and Immunoscore. The natural history of cancer involves interactions between the tumor and the immune system of the host. …”
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    Immunoscore and Immunoprofiling in cancer: an update from the melanoma and immunotherapy bridge 2015
  9. 4329
    por Choi, May Y., Fritzler, Marvin J.
    Publicado 2016
    “…RECENT FINDINGS: Recent evidence has helped to develop a clearer understanding of the natural history, early clinical features, and autoantibodies that are predictors of SSc. …”
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    Progress in understanding the diagnostic and pathogenic role of autoantibodies associated with systemic sclerosis
  10. 4330
    “…A case is presented in which oral DCA therapy resulted in tumour stabilization of stage 4 colon cancer in a 57 years old female for a period of nearly 4 years, with no serious toxicity. Since the natural history of stage 4 colon cancer consists of steady progression leading to disability and death, this case highlights a novel use of DCA as a cytostatic agent with a potential to maintain long-term stability of advanced-stage cancer.…”
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    Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy
  11. 4331
    “…This manuscript includes a review of the natural history of the disease, global disease burden estimates, diagnosis and existing control options in different settings, the biological rationale for a vaccine including previous supportive studies, analysis of current candidates in development, possible correlates of protection and current status of immunogenicity assays. …”
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    Group B Streptococcus vaccine development: present status and future considerations, with emphasis on perspectives for low and middle income countries
  12. 4332
    “…Our results suggest that even when current standards of care are applied, developmental milestones are rarely even partially achieved as part of natural history in type I SMA infants. No infants in this study achieved a major milestone such as rolling over, or sitting independently, which would therefore represent robust outcomes in future interventional trials.…”
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    Developmental milestones in type I spinal muscular atrophy
  13. 4333
    “…Knowledge of the CHD natural history facilitates comprehension of the potential development and progression of the disease, which differs among the aforementioned types. …”
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    Lessons learned from study of congenital hip disease in adults
  14. 4334
    “…The review aims to contribute to epidemiological studies and the knowledge on the natural history of ZIKV. The article concludes with questions that require urgent attention in epidemiological studies involving wildlife in order to understand their role as ZIKV hosts and to effectively control the epidemic.…”
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    Animals in the Zika Virus Life Cycle: What to Expect from Megadiverse Latin American Countries
  15. 4335
    “…LESSONS: This kind of tumor is extremely rare and the natural history of PEComa is uncertain, as the treatment protocol for hepatic PEComa has not reached a consensus. …”
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    Hepatic perivascular epithelioid cell tumor: Case report and brief literature review
  16. 4336
    “…No known treatment exists beyond symptomatic management, and while insights into the genetic cause, pathophysiology, neurobiology, and natural history of RTT have been gained, many challenges remain. …”
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    Neurobiologically-based treatments in Rett syndrome: opportunities and challenges
  17. 4337
    por Venniyoor, Ajit
    Publicado 2017
    “…Can we identify precursor lesions of ORCs and will early intervention of high risk individuals alter the natural history? It appears unlikely that the obesity epidemic will be controlled anytime soon; answers to these questions will help to reduce the adverse effect of obesity on human condition.…”
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    The most important questions in cancer research and clinical oncology—Question 2–5. Obesity-related cancers: more questions than answers
  18. 4338
    “…Further studies are required to enhance the comprehension of natural history of oral lesions.…”
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    High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil
  19. 4339
    “…Esophageal dilation seems to be therapeutic when dysphagia is present along with esophageal narrowing secondary to webs, rings or strictures. The natural history of the disease remains unclear and needs to be better delineated. …”
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    Lymphocytic esophagitis: Still an enigma a decade later
  20. 4340
    por Heery, Christopher R.
    Publicado 2016
    “…This review briefly describes the natural history and initial treatment of chordoma and focuses on treatment options for advanced disease and potential avenues of research that may lead to improved treatment options in the future.…”
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    Chordoma: The Quest for Better Treatment Options
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