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  1. 4401
    “…This web application, written in R, allows the semi-automated discovery of punctual biodiversity observations (e.g. biotic interactions, functional or behavioural traits and natural history descriptions) associated with the scientific names present inside a corpus of scientific literature. …”
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    Biodiversity Observations Miner: A web application to unlock primary biodiversity data from published literature
  2. 4402
    “…Using next generation sequencing, we assembled mitochondrial genomes of four Agathymus mariae group holotype specimens collected more than 55 years ago and housed pinned and dry in the American Museum of Natural History (New York, NY). We compared the holotype mitogenomes to those we obtained from fresh A. mariae specimens and the sister species Agathymus micheneri. …”
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    Mitogenomes of the four Agathymus holotypes collected 55 years ago
  3. 4403
    “…Neuroendocrine neoplasms are rare tumors that display marked heterogeneity with varying natural history, biological behavior, response to therapy and prognosis. …”
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    Current best practice in the management of neuroendocrine tumors
  4. 4404
    por Doria, Alessandro
    Publicado 2019
    “…Identifying these genes could lead to the development of innovative strategies to prevent the cardiovascular complications of diabetes by allowing us to 1) create predictive algorithms for the identification of patients at especially high risk of CVD so that these individuals can undergo preventive interventions early in the natural history of the disease; 2) discover as yet unknown disease pathways linking diabetes to atherosclerosis, which can be used as targets for the development of new CVD-preventing drugs specifically directed at subjects with diabetes; and 3) devise personalized programs increasing the cost-effectiveness of preventive interventions by tailoring them to the genetic background of each patient. …”
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    Leveraging Genetics to Improve Cardiovascular Health in Diabetes: The 2018 Edwin Bierman Award Lecture
  5. 4405
    por Chew, Sheena, Atassi, Nazem
    Publicado 2019
    “…The availability of PET radioligands that target a variety of potential pathophysiological mechanisms—including cerebral metabolism, neuroinflammation, neuronal dysfunction, and oxidative stress—has enabled dynamic interrogation of molecular changes in ALS, in both natural history studies and human clinical trials. PET imaging has potential as a diagnostic biomarker that can establish upper motor neuron (UMN) pathology in ALS patients without overt UMN symptoms, as a prognostic biomarker that might help stratify patients for clinical trials, and as a pharmacodynamic biomarker that measures the biological effect of investigational drugs in the brain and spinal cord. …”
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    Positron Emission Tomography Molecular Imaging Biomarkers for Amyotrophic Lateral Sclerosis
  6. 4406
    “…PURPOSE: Perianal adenocarcinoma arising from a chronic anorectal fistula is a rare condition for which the natural history and optimal management are not well established. …”
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    Anal Adenocarcinoma Can Masquerade as Chronic Anal Fistula in Asians
  7. 4407
    “…PREMISE OF THE STUDY: Herbarium specimens are increasingly used in phenological studies. However, natural history collections can have biases that influence the analysis of phenological events. …”
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    Patterns and biases in an Arctic herbarium specimen collection: Implications for phenological research
  8. 4408
    “…Given the widespread nature of HPV infection and the type specificity of currently available HPV vaccines, it is crucial that molecular details of the natural history of HPV infection as well as the biological activities of viral oncoproteins be elucidated. …”
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    Molecular mechanisms in progression of HPV-associated cervical carcinogenesis
  9. 4409
    “…As well as setting out the rarity of this case, our work intends to review the current literature regarding the epidemiology, natural history, diagnosis and management of jejuno-ileal diverticula…”
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    Jejuno-ileal diverticulitis: A disorder not to underestimate
  10. 4410
    “…All South African material held at the National Museum of Natural History, Paris, France (MNHN) and the Iziko South African Museum, Cape Town (SAMC) identified as, or appearing to belong to, Elthusa was examined. …”
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    Review of the fish parasitic genus Elthusa Schioedte & Meinert, 1884 (Crustacea, Isopoda, Cymothoidae) from South Africa, including the description of three new species
  11. 4411
    “…Significant advances in knowledge of the natural history and clinical diversity have been documented, and an improved pathological classification of gliomas that integrates histological features with molecular markers has been issued by the WHO. …”
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    Diffuse Low-Grade Glioma – Changing Concepts in Diagnosis and Management: A Review
  12. 4412
    “…It is difficult to determine (1) when PCa disseminates in the natural history of the disease; (2) where cancer cell disseminates before becoming overt metastatic lesions; and (3) which tumors are aggressive and which are indolent. …”
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    Optimization of prostate cancer cell detection using multiplex tyramide signal amplification
  13. 4413
    “…The protective role of Fc-mediated antibody-function in HIV-1 immunity has led to the investigation of specific polymorphisms in FcR genes on acquisition, disease progression, and vaccine efficacy in natural history cohorts. The purpose of this review is not only to explore these known HIV-1 host genetic associations, but also to re-evaluate them in the context of genome-wide data. …”
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    Effect of Fc Receptor Genetic Diversity on HIV-1 Disease Pathogenesis
  14. 4414
    “…Next, we undertook a citizen science experiment at the Natural History Museum London, where human subjects (“predators”) searched for crabs representing natural colour variation from different habitats, simulating predator vision. 6. …”
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    Improved camouflage through ontogenetic colour change confers reduced detection risk in shore crabs
  15. 4415
    por Sivaprasad, S., Pearce, E.
    Publicado 2018
    “…For lesions commonly seen in hypertensive retinopathy, a detailed assessment of potential concomitant diseases is also recommended. We believe that natural history studies of these changes will help characterize these non‐proliferative diabetic retinopathy progression profiles and advance our understanding of the pathogenesis of diabetic retinopathy in order to individualize management of people with diabetic retinopathy.…”
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    The unmet need for better risk stratification of non‐proliferative diabetic retinopathy
  16. 4416
    “…Key questions on epidemiology, natural history, diagnosis, and management were developed. …”
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    Management of chronic urticaria in children: a clinical guideline
  17. 4417
    “…The digestive tracts of four specimens were examined for parasites; three of these were archived in the American Museum of Natural History and one was a live capture. Relative to the other four monotypic genera of pinworms known to infect opossums, the new genus is diagnosed on the basis of a round cephalic plate with a semicircular stoma surrounded by a rim. …”
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    A new genus and species of pinworm (Nematoda, Oxyuridae) from the gray mouse opossum, Tlacuatzin canescens
  18. 4418
    “…CONCLUSIONS: Male sex, age, and sleep disorders are risk factors for persistent or recurrent CSC in the natural history. These patients may require early photodynamic therapy. …”
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    Risk Factors for Persistent or Recurrent Central Serous Chorioretinopathy
  19. 4419
    “…To determine the characteristics of the black type, we summarised external morphology and skull osteometric data obtained from four individuals, which included three individuals from Hokkaido and one additional individual from the United States National Museum of Natural History collection. The whales differed from all of their congeners by having the following unique characters: a substantially smaller body size of physically mature individuals, proportionately shorter beak, and darker body colour. …”
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    Description of a new species of beaked whale (Berardius) found in the North Pacific
  20. 4420
    “…PURPOSE: Approximately 4% to 10% of patients diagnosed with Chagas-induced megaesophagus disease develop esophageal carcinoma. However, the natural history and clinical pattern of this entity are not well described. …”
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    Chagasic Megaesophagus–Associated Carcinoma: Clinical Pattern and Outcomes
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