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  1. 4441
    “…In most HIV-infected persons, the natural history of untreated infection is one of sustained viremia, progressive CD4 T cell depletion with resultant morbidity and mortality. …”
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    Antiretroviral Treatment for HIV Elite Controllers?
  2. 4442
    “…Identifying the native range of invasive species is useful to understand their evolution and natural history, as well as to develop new methods to control potentially harmful introduced organisms. …”
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    Globally invasive populations of the clonal raider ant are derived from Bangladesh
  3. 4443
    “…Basilar artery perforator aneurysms (BAPAs) are a rare cause of subarachnoid hemorrhage (SAH), and the natural history is still unknown. Herein, we report a case of ruptured BAPA that appeared during the observation period and then spontaneously disappeared; we have also conducted a review of the literature and performed an analysis based on the type of management. …”
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    Ruptured Basilar Artery Perforator Aneurysm: A Case Report and Review of the Literature
  4. 4444
    “…Eradication may influence gastrointestinal microbiota adversely, unlocking the next stage in the natural history, the development of rigidity. Failed eradication worsens hypokinesia, as does the presence/persistence of H. pylori at molecular level only. …”
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    Role of Helicobacters in Neuropsychiatric Disease: A Systematic Review in Idiopathic Parkinsonism
  5. 4445
    “…Ventricular assist devices (VADs) have played an important role in altering the natural history of end-stage heart failure. Low-grade hemolysis has been traditionally described in patients with VADs, indicating effective device functionality. …”
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    Comprehensive review of hemolysis in ventricular assist devices
  6. 4446
    por Zavatta, Guido, Clarke, Bart L
    Publicado 2020
    “…Unresolved questions remain about the significance of NHPT when it is diagnosed biochemically without evident bone or kidney complications. Moreover, its natural history remains to be elucidated because a proportion of what is classified as NHPT may revert to normal spontaneously, thus revealing previously unrecognized secondary hyperparathyroidism. …”
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    Normocalcemic Hyperparathyroidism: A Heterogeneous Disorder Often Misdiagnosed?
  7. 4447
    por Wang, Raymond Y.
    Publicado 2020
    “…While uncertainties regarding natural history and prognosis of presymptomatically-identified late-onset Pompe disease infants will be elucidated with additional experience, suggestions for education of first-line providers are provided to accurately communicate results and compassionately counsel families regarding anxiety-provoking positive newborn screen results.…”
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    A Newborn Screening, Presymptomatically Identified Infant With Late-Onset Pompe Disease: Case Report, Parental Experience, and Recommendations
  8. 4448
    “…Despite its benign histological appearance, it can invade nearby structures or metastasize hence clinicians need to have a high index of suspicion for early diagnosis. The natural history of the disease is seldom predictable and ranges anywhere from indolent to aggressive malignant course. …”
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    Rarity among the rare-large and invasive thymoma, a case report and review
  9. 4449
    por Li, Miao, Liang, Huaxin, Wang, Jie
    Publicado 2020
    “…Background: Giant vertebrobasilar aneurysms (GVBAs) have an unfavorable natural history if left untreated and often pose a sizeable challenge to endovascular treatment. …”
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    Unfavorable Outcomes Related to Endovascular Treatment of Giant Vertebrobasilar Aneurysms
  10. 4450
    “…The natural history of allergic diseases suggests bidirectional and progressive relationships between allergic disorders of the skin, lung and gut indicative of mucosal organ cross-talk. …”
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    Remote Allergen Exposure Elicits Eosinophil Infiltration into Allergen Non-Exposed Mucosal Organs and Primes for Allergic Inflammation
  11. 4451
    “…Asymptomatic VPE refers to the presence of this abnormal ECG pattern in the absence of any symptoms. The natural history in these patients is usually benign, and most children (60%) with VPE are usually asymptomatic. …”
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    Risk-Stratification Strategy for Sudden Cardiac Death in the Very Young Children with Asymptomatic Ventricular Preexcitation
  12. 4452
    “…Impeded by a lack of natural history, knowledge gained from individual case studies forms the source for a reliable diagnosis and consultation of patients and parents. …”
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    A homozygous missense variant of SUMF1 in the Bedouin population extends the clinical spectrum in ultrarare neonatal multiple sulfatase deficiency
  13. 4453
    “…Notable achievements in the last decade include promulgating the first U.S. clinical research guidance, setting up registries and natural history studies, and investing in companies—some of which have brought potentially disease-modifying products to the market. …”
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    Accelerating Rare Disease Drug Development: Lessons Learned from Muscular Dystrophy Patient Advocacy Groups
  14. 4454
    por Asaad, Salim Zafar
    Publicado 2020
    “…This review provides an overview of the evolving concepts of LMHs and analyses its natural history from study cases in previously published literature.…”
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    Lamellar macular holes: evolving concepts and propensity for progression to full thickness macular hole
  15. 4455
    por Baker, Kate S.
    Publicado 2020
    “…Now in the genomic age, modern-day microbe hunters are combining pathogen whole-genome sequencing with epidemiological data to enhance epidemiological investigations, advance our understanding of the natural history of pathogens and drivers of disease, and ultimately reshape our plans and priorities for global disease control and eradication. …”
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    Microbe hunting in the modern era: reflecting on a decade of microbial genomic epidemiology
  16. 4456
    “…Fenestration of the supraclinoid internal carotid artery (ICA) is extremely rare and may occasionally be associated with saccular aneurysms; nevertheless, the natural history remains unclear. The authors reviewed the cases of fenestration of the supraclinoid ICA and evaluated the clinical characteristics and angioarchitecture with particular focus on the incidence for aneurysm development and rupture. …”
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    Supraclinoid Internal Carotid Artery Fenestration with Associated Aneurysm: Case Report and Literature Review
  17. 4457
    “…This comprehensive data will ultimately help us to understand the natural history of SCD in India and also help the Government to formulate strategies for the management and prevention of sickle cell disease in India.…”
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    Newborn Screening for Sickle Cell Disease: Indian Experience
  18. 4458
    “…In this study, we utilize a mathematical model motivated by aspects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) natural history to investigate how evolutionary changes in survival may influence several aspects of disease dynamics at the epidemiological scale. …”
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    The Epidemiological Signature of Pathogen Populations That Vary in the Relationship between Free-Living Parasite Survival and Virulence
  19. 4459
    “…However, there have been relatively few studies on the natural history of the two major human arbovirus vectors in this region, Aedes aegypti and Ae. albopictus, potentially limiting the implementation of effective vector control. …”
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    Review of the ecology and behaviour of Aedes aegypti and Aedes albopictus in Western Africa and implications for vector control
  20. 4460
    “…The joint damage starts early in the course of the disease, thus early recognition and treatment with modern biological treatments, which may modify the natural history and slow down progression of this debilitating disease, is essential for the patient long-term outcome.…”
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    Pathogenesis of psoriasis in the “omic” era. Part IV. Epidemiology, genetics, immunopathogenesis, clinical manifestation and treatment of psoriatic arthritis
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