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  1. 4681
    “…To address this apparent paradox and to gain more insight into the pathophysiology of aneurysmal disease, we characterized a new Tgfbr1 mouse model carrying a p.Y378* nonsense mutation. Study of the natural history in this model showed that homozygous mutant mice die during embryonic development due to defective vascularization. …”
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    Absence of Cardiovascular Manifestations in a Haploinsufficient Tgfbr1 Mouse Model
  2. 4682
    “…Thus, the tissue of origin reflects on the natural history of the disease and dictates the therapeutic approach. …”
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    Tissue Specific DNA Methylation in Normal Human Breast Epithelium and in Breast Cancer
  3. 4683
    “…The development of intestinal metaplasia (IM) has been purported to be a critical step in the pathogenesis of gastric cancer. However, the natural history of IM in migrant human populations has not been well elucidated. …”
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    Intestinal Metaplasia and the Risk of Gastric Cancer in an Immigrant Asian Population
  4. 4684
    “…Given that headache is a major factor contributing to school absenteeism and poorer quality of life not only in childhood but also in adolescence, understanding the natural history and the management of the different headache forms is vital for our future.…”
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    The evolution of headache from childhood to adulthood: a review of the literature
  5. 4685
    “…The knowledge of natural history and genotype–phenotype correlation may help in developing a tailored therapy potentially using enzyme replacement therapy with substrate reduction therapy or chaperones.…”
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    Attenuated osteoarticular phenotype of type VI mucopolysaccharidosis: a report of four patients and a review of the literature
  6. 4686
    “…According to published data several pulmonary biomarkers assessed in ECOPD have the potential to illustrate the natural history of disease through the modification of their levels. …”
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    Pulmonary biomarkers in COPD exacerbations: a systematic review
  7. 4687
    “…HIV has been known to interfere with the natural history of hepatitis B virus (HBV) infection. …”
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    Occult Hepatitis B Virus Infection among HIV Positive Patients in Nigeria
  8. 4688
    por Austin, R. Marshall, Zhao, Chengquan
    Publicado 2014
    “…Observational studies of large populations screened over time remain essential to document actual protection from development of cervical cancer with any new cervical screening options, as natural history studies and available data from large systems indicate that most CIN2/3 cases detected in short term clinical trials would not progress to invasive cervical cancer. …”
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    Is 58% sensitivity for detection of cervical intraepithelial neoplasia 3 and invasive cervical cancer optimal for cervical screening?
  9. 4689
    “…CONCLUSIONS: The detailed knowledge of single muscle involvement provides useful information for correctly evaluating patients' motor function and to set a baseline for natural history studies. Upper girdle imaging can also be used as an additional tool helpful in supporting the diagnosis of FSHD in unclear situations, and may contribute with hints on the currently largely unknown molecular pathogenesis of this disease.…”
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    Upper Girdle Imaging in Facioscapulohumeral Muscular Dystrophy
  10. 4690
    “…In conclusion, this report describes the natural history of growth in patients with MPS II, which can help in monitoring the progression of the disease as well as assessing therapeutic efficacy.…”
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    Growth charts for patients with Hunter syndrome()
  11. 4691
    “…The objective of this study was to determine the incidence of CMV retinitis and the effect of HAART on the natural history of CMV retinitis in patients referred from ART center. …”
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    Cytomegalovirus retinitis in acquired immunodeficiency syndrome patients: A problem worth giving attention to
  12. 4692
    “…Susac syndrome is an autoimmune microangiopathy affecting the brain, retina and inner ear (cochlea and semicircular canals), leading to encephalopathy, branch retinal artery occlusions (BRAOs) and asymmetric neurosensory hearing loss, respectively. The natural history and long-term prognosis are variable as the disease has been shown to be monophasic and self-limiting, polycyclic or chronic continuous. …”
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    Recurrence of Susac Syndrome following 23 Years of Remission
  13. 4693
    “…The neurohormonal blockade modifies this natural history; however, it is often suboptimal. OBJECTIVE: The aim of this study is to assess at what percentage cardiologists used to treating HF can prescribe target doses of drugs of proven efficacy. …”
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    Optimized Treatment and Heart Rate Reduction in Chronic Heart Failure
  14. 4694
    por Chaisson, Eric J.
    Publicado 2014
    “…These are global history greatly extended, big history with a scientific basis, and natural history broadly portrayed across ∼14 billion years of time. …”
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    The Natural Science Underlying Big History
  15. 4695
    “…BACKGROUND: This article reports historical ethnobotany research conducted from a study of the work Historia Naturalis Brasiliae (Natural History of Brazil), authored by Piso and Marcgrave and published in 1648, with main focus on Caatinga of northeast region of Brazil. …”
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    Food flora in 17th century northeast region of Brazil in Historia Naturalis Brasiliae
  16. 4696
    “…Based on individual-level biannual repeat data on SRH we sought to characterize the natural history of poor SRH during the 12 years prior to death in men and women in different age groups. …”
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    Self-Rated Health in the Last 12 Years of Life Compared to Matched Surviving Controls: The Health and Retirement Study
  17. 4697
    “…METHOD: To promote an evidence-informed application of the law in Canada, a team of six Canadian medical experts on HIV and transmission led the development of a consensus statement on HIV sexual transmission, HIV transmission associated with biting and spitting, and the natural history of HIV infection. The statement is based on a literature review of the most recent and relevant scientific evidence (current as of December 2013) regarding HIV and its transmission. …”
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    Canadian consensus statement on HIV and its transmission in the context of criminal law
  18. 4698
    “…The aim of this study was to describe the natural history of intestinal permeability, mucosal and neuromuscular inflammation and nitrergic motor neuron function during the lifetime of the BioBreeding (BB) rat. …”
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    From Intestinal Permeability to Dysmotility: The Biobreeding Rat as a Model for Functional Gastrointestinal Disorders
  19. 4699
    por Singh, J C, Jhaveri, K, Esteva, F J
    Publicado 2014
    “…Effective targeting of the human epidermal growth factor receptor 2 (HER2) has changed the natural history of HER2 overexpressing (HER2+) metastatic breast cancer. …”
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    HER2-positive advanced breast cancer: optimizing patient outcomes and opportunities for drug development
  20. 4700
    “…The aim of this study was to identify determinants of HPV16 seroreactivity at enrollment among women from the Ludwig-McGill cohort, a natural history study of HPV infection and risk of cervical neoplasia. …”
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    Determinants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort study
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