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  1. 8221
    “…Understanding the natural history of CVD in Haitians, including the age of onset, prevalence, incidence, and role of major risk factors and social determinants, is urgently needed to develop prevention and treatment interventions. …”
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    The Haiti cardiovascular disease cohort: study protocol for a population-based longitudinal cohort
  2. 8222
    “…BACKGROUND: The emergence of the novel coronavirus, SARS-CoV-2, created a crucial need for accurate tests for diagnosis, assessment of prior infection, and understanding its natural history. Serology assays play an important role in the assessment of anti-viral immune responses and previous infections. …”
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    LB-15. A Trans-Governmental Collaborative Effort to Independently Evaluate SARS-CoV-2 Serology Assays Using Well-Characterized Sample Panels
  3. 8223
    “…The aim of this study was to analyze for the first time cognitive functions, language comprehension, and speech in natural history SMA1 children according to age and subtypes, to develop cognitive and language benchmarks that provide outcomes for the clinical medication trials that are changing SMA1 course/trajectory. …”
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    Intellectual abilities, language comprehension, speech, and motor function in children with spinal muscular atrophy type 1
  4. 8224
    “…Input from patients and their representatives should guide clinical trials, increase the availability of genetic testing, and generate natural history and qualitative studies detailing patients’ experience. …”
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    Patient and family experience with transthyretin amyloid cardiomyopathy (ATTR-CM) and polyneuropathy (ATTR-PN) amyloidosis: results of two focus groups
  5. 8225
    “…METHODS: Based on the natural history of HBV infection and three national serosurvey data of hepatitis B in China, we developed an age- and sex-specific discrete model to describe the transmission dynamics of HBV. …”
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    Evaluating the independent influence of sexual transmission on HBV infection in China: a modeling study
  6. 8226
    “…Due to the high prevalence of AD in DS, there is need for longitudinal imaging studies of Aβ to better characterize the natural history of Aβ accumulation, which will aid in the staging of this population for clinical trials aimed at AD treatment and prevention. …”
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    PET measurement of longitudinal amyloid load identifies the earliest stages of amyloid-beta accumulation during Alzheimer’s disease progression in Down syndrome
  7. 8227
    “…METHODS: This retrospective analysis compared efficacy of avapritinib in patients enrolled in the NAVIGATOR phase 1 trial (NCT02508532) with the efficacy of other tyrosine kinase inhibitors (TKIs) in patients with unresectable/metastatic PDGFRA D842V-mutant GIST enrolled in a retrospective natural history study (Study 1002). The primary endpoint was overall survival (OS) from the start of reference treatment (avapritinib for NAVIGATOR patients or first-line TKI for treatment of unresectable/metastatic GIST for Study 1002 patients); the secondary endpoint was progression-free survival (PFS). …”
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    Clinical efficacy comparison of avapritinib with other tyrosine kinase inhibitors in gastrointestinal stromal tumors with PDGFRA D842V mutation: a retrospective analysis of clinical trial and real-world data
  8. 8228
    “…New therapies have been developed in recent years that change the natural history of the disease. The aim of this study is to describe patients included in the Polish Registry of SMA, with a focus on the course of type 3 SMA (SMA3) before the availability of disease-modifying treatments. …”
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    Observation of the natural course of type 3 spinal muscular atrophy: data from the polish registry of spinal muscular atrophy
  9. 8229
    “…The incidence, clinical impact, risk factors, and natural history of FTR in the setting of ischemic mitral regurgitation (IMR) are less known. …”
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    Tricuspid regurgitation in ischemic mitral regurgitation patients: prevalence, predictors for outcome and long-term follow-up
  10. 8230
    “…They markedly differ from thymic NETs in their natural history, morphology, prognosis, and therapeutic options. …”
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    Thymoma and Not Just Thymic Carcinoid Can Be Associated With Multiple Endocrine Neoplasia Type 1
  11. 8231
    “…BACKROUND: Human leukocyte antigen (HLA)-G may have an important role in the natural history of human papillomavirus (HPV) infection. …”
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    HLA-G polymorphism impacts the outcome of oral HPV infections in women
  12. 8232
    “…We evaluated associations between depression, self-reported adherence, and longitudinal HIV treatment outcomes in US Military HIV Natural History Study (NHS) participants with and without depression. …”
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    Association between depression and HIV treatment outcomes in a US military population with HIV infection
  13. 8233
    “…Though earlier studies have reported that cancer patients are at an increased risk for mortality due to COVID-19 when compared to the general population, questions remain unanswered as to how specific agents used to treat malignancies affect the natural history of COVID-19. In particular, the effect of anti-CD20 therapy in patients with lymphoid malignancies remains unexplored in patients who contract COVID-19 during their treatment. …”
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    Outcomes in Patients with Hematological Malignancies Receiving Anti-CD20 Therapy in the Setting of COVID-19 Infection
  14. 8234
    “…METHODS: We describe medication and non-medication approaches to treatment of epilepsy and additional key neurologic symptoms (sleep disturbances, behavioral issues, movement disorders, and swallowing dysfunction) in a cohort of 177 individuals meeting criteria for CDD, 154 evaluated at 4 CDKL5 Centers of Excellence in the USA and 40 identified through the NIH Natural History Study of Rett and Related Disorders. RESULTS: The four most frequently prescribed anti-seizure medications were broad spectrum, prescribed in over 50% of individuals. …”
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    Current neurologic treatment and emerging therapies in CDKL5 deficiency disorder
  15. 8235
    “…Some investigators have correlated the absorbed energy at the time of the injury with the natural history of the pilon fracture despite the quality of the surgical reconstruction. …”
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    Fractures of The Tibial Plafond: Does the Presence or Absence of a Fibular Fracture Predict Future Morbidity?
  16. 8236
    “…Brain atrophy patterns are recognised as signatures of neurodegenerative conditions, but the natural history of brain atrophy after stroke remains poorly described. …”
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    Neurodegeneration Over 3 Years Following Ischaemic Stroke: Findings From the Cognition and Neocortical Volume After Stroke Study
  17. 8237
    por Deer, Rachel R, Rock, Madeline A, Vasilevsky, Nicole, Carmody, Leigh, Rando, Halie, Anzalone, Alfred J, Basson, Marc D, Bennett, Tellen D, Bergquist, Timothy, Boudreau, Eilis A, Bramante, Carolyn T, Byrd, James Brian, Callahan, Tiffany J, Chan, Lauren E, Chu, Haitao, Chute, Christopher G, Coleman, Ben D, Davis, Hannah E, Gagnier, Joel, Greene, Casey S, Hillegass, William B, Kavuluru, Ramakanth, Kimble, Wesley D, Koraishy, Farrukh M, Köhler, Sebastian, Liang, Chen, Liu, Feifan, Liu, Hongfang, Madhira, Vithal, Madlock-Brown, Charisse R, Matentzoglu, Nicolas, Mazzotti, Diego R, McMurry, Julie A, McNair, Douglas S, Moffitt, Richard A, Monteith, Teshamae S, Parker, Ann M, Perry, Mallory A, Pfaff, Emily, Reese, Justin T, Saltz, Joel, Schuff, Robert A, Solomonides, Anthony E, Solway, Julian, Spratt, Heidi, Stein, Gary S, Sule, Anupam A, Topaloglu, Umit, Vavougios, George D., Wang, Liwei, Haendel, Melissa A, Robinson, Peter N
    Publicado 2021
    “…Patient-led studies are of particular importance for understanding the natural history of COVID-19, but integration is hampered because they often use different terms to describe the same symptom or condition. …”
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    Characterizing Long COVID: Deep Phenotype of a Complex Condition
  18. 8238
    “…BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is characterized by a poor prognosis, with a progressive decline in lung function and considerable variability in the disease’s natural history. Besides lung transplantation (LTx), the only available treatments are anti-fibrosing drugs, which have shown to slow down the disease course. …”
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    Validation of the risk stratification score in idiopathic pulmonary fibrosis: study protocol of a prospective, multi-centre, observational, 3-year clinical trial
  19. 8239
    “…METHODS: A search for studies reporting computer simulation models of the natural history of individuals with type 2 diabetes and/or decision models to evaluate the impact of treatment strategies on these populations was conducted in PubMed. …”
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    A review of simulation models for the long-term management of type 2 diabetes in low-and-middle income countries
  20. 8240
    “…Our data show great heterogeneity in nAb responses among people with recent COVID-19, highlighting the challenges of interpreting natural history studies and gauging responses to vaccines and therapeutics among people with recent infection. …”
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    Neutralizing antibody responses over time in demographically and clinically diverse individuals recovered from SARS-CoV-2 infection in the United States and Peru: A cohort study
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