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  1. 8301
    por Li, Miao, Jiang, Jue, Zhou, Qi, Zhang, Chen
    Publicado 2019
    “…This one-year prospective study aimed to investigate the natural history of the neuroanatomical morphology of the median nerve after ECTR in severe CTS patients by high-frequency ultrasonography and assess the ability of neuroanatomical measures to quantify morphological recovery of the median nerve after ECTR. …”
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    Sonographic follow-up after endoscopic carpal tunnel release for severe carpal tunnel syndrome: a one-year neuroanatomical prospective observational study
  2. 8302
    “…Development of a disease biomarker would augment observational studies seeking to further define the risk factors, natural history, and clinical features of LATE, as well as eventual subject recruitment for targeted therapies in clinical trials.…”
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    Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
  3. 8303
    “…Few data are available on the natural history and correct management of this disease. …”
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    MON-LB090 Red-Hipopara, Real Life Experience in 322 Patients with Hypoparathyroidism in Argentina
  4. 8304
    “…We also examined how the natural history of the RPD (whether the dilatation persists in later pregnancy or postpartum) or its characteristics (unilateral versus bilateral) changed the risk of hospital admission. …”
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    Mild-to-moderate renal pelvis dilatation identified during pregnancy and hospital admissions in childhood: An electronic birth cohort study in Wales, UK
  5. 8305
    “…We describe ART outcomes in HIV-positive AD military utilizing data collected over 15 years in our prospective, multi-center HIV Natural History Study (NHS). METHODS: We included AD NHS participants diagnosed with HIV from 2002–2016 with ≥1 year of follow-up. …”
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    1263. Anti-Retroviral (ART) Success in an Active Duty Military Cohort from 2002 to 2016, A Model for Ending the HIV Epidemic in the United States
  6. 8306
    “…Thus, we provide mechanistic insight into the disease pathogenesis associated with MSTO1 mutations and further define the clinical spectrum and the natural history of MSTO1-related disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00401-019-02059-z) contains supplementary material, which is available to authorized users.…”
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    MSTO1 mutations cause mtDNA depletion, manifesting as muscular dystrophy with cerebellar involvement
  7. 8307
    “…CONCLUSIONS: This prospective observational study indicates a mild treatment effect in adults with long-standing SMA3 after 10 months of treatment with Nusinersen, which had never occurred in the natural history of the disease. In our cohort, the most significant outcome measures were the 6MWT with statistically significant changes after day 180 and day 300, RULM after day 300 and peak cough flow after day 180.…”
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    Safety and Treatment Effects of Nusinersen in Longstanding Adult 5q-SMA Type 3 – A Prospective Observational Study
  8. 8308
    “…Thus, we aimed to describe natural history of myelolipoma and to identify predictors of tumor growth and need for surgery. …”
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    SAT-170 Clinical Course of Adrenal Myelolipoma: A Long-Term Longitudinal Follow-Up Study
  9. 8309
    “…Methods: We queried a prospective natural history study of MEN1 patients who tested positive for germline MEN1 mutations (n=287) between 1991-2019 (54 patients on our current protocol were followed before 1991; the earliest was 1971). …”
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    SUN-124 Are Venous Thromboembolic Events Increased in MEN1 Patients?
  10. 8310
    “…Future studies may determine genotype-phenotype correlations regarding the natural history of these neoplasms. Because of the potential clinical implications of these genomic markers for patient management, all 104 fusions described here are now included among the 235 gene pairs reported by the expanded Afirma XA.…”
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    OR28-04 Identification of Novel and Rare Receptor Tyrosine Kinase Fusions in Thyroid Fine Needle Aspirates
  11. 8311
    “…Studies have assessed Alzheimer's disease in individuals with Down syndrome, but the natural history of biomarker changes in Down syndrome has not been established. …”
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    Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study
  12. 8312
    “…ABSTRACT: Introduction: The three different breast cancer subtypes (Luminal, HER2-positive, and triple negative (TNBCs) display different natural history and sensitivity to treatment, but little is known about whether residual axillary disease after neoadjuvant chemotherapy (NAC) carries a different prognostic value by BC subtype. …”
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    The Prognostic Value of Lymph Node Involvement after Neoadjuvant Chemotherapy Is Different among Breast Cancer Subtypes
  13. 8313
    “…Key conclusions and recommendations include (1) the importance of establishing laboratory criteria that signal potential DILI events and that fit the disease indication being studied in the clinical trial based on knowledge of the natural history of test fluctuations in that disease; (2) establishing a pretreatment value that is based on more than one screening determination, and revising that baseline during the trial if a new nadir is achieved during treatment; (3) basing rules for increased monitoring and for stopping drug for potential DILI on multiples of baseline liver test values and/or a threshold value rather than multiples of the upper limit of normal (ULN) for that test; (4) making use of more sensitive tests of liver function, including direct bilirubin (DB) or combined parameters such as aspartate transaminase:alanine transaminase (AST:ALT) ratio or model for end-stage liver disease (MELD) to signal potential DILI, especially in studies of patients with cirrhosis; and (5) being aware of potential confounders related to complications of the disease being studied that may masquerade as DILI events. …”
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    Consensus Guidelines: Best Practices for Detection, Assessment and Management of Suspected Acute Drug-Induced Liver Injury During Clinical Trials in Adults with Chronic Viral Hepatitis and Adults with Cirrhosis Secondary to Hepatitis B, C and Nonalcoholic Steatohepatitis
  14. 8314
    “…Factors other than insulin resistance (ie, insulin secretion) may play an important role in the natural history of diabetes in South Asians.…”
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    Incidence and pathophysiology of diabetes in South Asian adults living in India and Pakistan compared with US blacks and whites
  15. 8315
    “…Little is known about the natural history of metabolic health in this population. …”
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    Natural course of metabolically healthy phenotype and risk of developing Cardiometabolic diseases: a three years follow-up study
  16. 8316
    “…Currently, the incidence of hydrocephalus in untreated SMA patients is not available, thereby making it difficult to determine if hydrocephalus is a side effect of nusinersen or part of SMA’s natural history. This retrospective, matched cohort study used electronic health records (EHRs) to estimate and compare the incidence of hydrocephalus in both SMA patients and matched non-SMA controls in the time period prior to the approval of nusinersen. …”
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    The incidence of hydrocephalus among patients with and without spinal muscular atrophy (SMA): Results from a US electronic health records study
  17. 8317
    “…Further diagnoses will lead to increased information on natural history/mechanistic details, and likely increased therapies and clinical trials.…”
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    Diagnostic yield of rare skeletal dysplasia conditions in the radiogenomics era
  18. 8318
    “…The MHMRTDM was developed according to the natural history of HEV cases among humans and pigs and the multi-transmission routes such as person-to-person, pig-to-person, and environment-to-person. …”
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    Feasibility of controlling hepatitis E in Jiangsu Province, China: a modelling study
  19. 8319
    “…This case uniquely spans eight years and therefore offers valuable insight into the appropriate work-up, management and long-term natural history of low fT4 in persons with HIV.…”
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    Discordant Thyroid Function Tests in Patients With HIV: A Case Report and Discussion of Diagnostic Approach
  20. 8320
    “…BACKGROUND: The benefit and the risk profile of Gamma Knife radiosurgery (GKRS) for intracerebral cavernoma remains incompletely defined in part due to the natural history of low incidence of bleeding and spontaneous regression of this vascular malformation. …”
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    Outcome of intracerebral cavernoma treated by Gamma Knife radiosurgery based on a double-blind assessment of treatment indication
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