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  1. 1841
    “…ROS overproduction is a feature of cancer cells and plays several roles during the natural history of malignant tumor. ROS continuously contribute to each step of cancerogenesis, from the initiation to the malignant progression, acting directly or indirectly. …”
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    The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression
  2. 1842
    “…Objective: To analyze a 7-year natural history of idiopathic multiple retinal pigment epithelium (RPE) detachment based on optical coherence tomography (OCT) images. …”
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    Seven-year evaluation of idiopathic multiple retinal pigment epithelium detachments
  3. 1843
    “…Our results further demonstrate the utility of natural history collections, paired with modern field sampling, to document biological response to climate change and other human impacts.…”
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    Historical shell size reduction of the dogwhelk (Nucella lapillus) across the southern UK
  4. 1844
    por Rubin, Berish Y, Anderson, Sylvia L
    Publicado 2017
    “…Here, we present the research advances and scientific breakthroughs that have changed and will continue to change the natural history of this centuries-old genetic disease.…”
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    IKBKAP/ELP1 gene mutations: mechanisms of familial dysautonomia and gene-targeting therapies
  5. 1845
    “…The preceding decades have generated a wealth of information regarding the natural history of pre-type 1 diabetes. Islet autoimmunity in the form of multiple autoantibodies is known to be highly predictive of progression to disease. …”
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    Understanding Pre-Type 1 Diabetes: The Key to Prevention
  6. 1846
    por Wang, Zhenhua, Zhang, Qiang, Wu, Bin
    Publicado 2019
    “…OBJECTIVE: This study constructs, calibrates, and verifies a mathematical simulation model designed to project the natural history of ESCC and is intended to serve as a platform for testing the benefits and cost-effectiveness of primary and secondary ESCC prevention alternatives. …”
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    Development of an Empirically Calibrated Model of Esophageal Squamous Cell Carcinoma in High-Risk Regions
  7. 1847
    “…Research about the natural history and underlying pathophysiological mechanisms of rare diseases, as well as clinical trials with new drugs, are important and necessary to develop new strategies for the treatment of these conditions. …”
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    Clinical research challenges in rare genetic diseases in Brazil
  8. 1848
    “…Excess mortality (all-cause) was estimated using natural history models. Additional mortality attributed to MNSDs as underlying causes but not captured through GBD 2010 methodology is quantified in the comparative risk assessments. …”
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    Excess mortality from mental, neurological and substance use disorders in the Global Burden of Disease Study 2010
  9. 1849
    “…Regenerative translational studies must include a longitudinal assessment of the changes in retinal structure and function that occur as part of the natural history of the disease and those that result from the studied intervention. …”
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    In vivo retinal imaging in translational regenerative research
  10. 1850
    “…The purpose of this study was to provide a comprehensive report of the natural history of retinal changes in this dog model. …”
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    A Comprehensive Study of the Retinal Phenotype of Rpe65-Deficient Dogs
  11. 1851
    por Misumi, Megumi, Nishiura, Hiroshi
    Publicado 2021
    “…However, a model with time-varying natural history parameters yielded better goodness-of-fit and suggested that the asymptomatic ratio varied by year. …”
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    Long-term dynamics of Norovirus transmission in Japan, 2005–2019
  12. 1852
    por Rath, Anika, Weintraub, Robert
    Publicado 2021
    “…This review provides an overview of childhood cardiomyopathies with a focus on epidemiology, natural history, and outcomes.…”
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    Overview of Cardiomyopathies in Childhood
  13. 1853
    “…The present study was undertaken to evaluate the natural history of HPT after renal transplantation and to determine risk factors for persistent HPT in the era of calcimimetic. …”
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    Effect of Pretransplant Use of Calcimimetic on Parathyroid Function after Renal Transplantation
  14. 1854
    “…We plead for a rehabilitation of B-cell studies related to both the natural history of HBV and treatment development programmes.…”
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    Humoral immunity in hepatitis B virus infection: Rehabilitating the B in HBV
  15. 1855
    “…RESULTS: Landmark natural history studies demonstrated the significance of size, location, and other risk factors for aneurysm rupture, but prior studies have significant limitations. …”
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    Unruptured cerebral aneurysm risk stratification: Background, current research, and future directions in aneurysm assessment
  16. 1856
    por Huey, Raymond B, Buckley, Lauren B
    Publicado 2022
    “…But mimicking natural conditions in the laboratory is challenging—doing so requires prior natural-history knowledge of ecologically relevant body temperature cycles, photoperiods, food rations, social environments, among other variables. …”
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    Designing a Seasonal Acclimation Study Presents Challenges and Opportunities
  17. 1857
    “…Clinical guidelines recommending treatment thresholds are not specific to sub-Saharan African patients and are based on natural history studies from Western Pacific Asian countries. …”
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    Health inequalities in the management of chronic hepatitis B virus infection in patients from sub-Saharan Africa in high-income countries
  18. 1858
    “…Moreover, the detailed case description and natural history along with the comprehensive review of the literature contribute to the understanding of this complex disorder and point to the need for comprehensive clinical assessments of SHM1.…”
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    Concomitant Calcium Channelopathies Involving CACNA1A and CACNA1F: A Case Report and Review of the Literature
  19. 1859
    por Darwin, Charles, 1809-1882
    Publicado 2003
    Libro
    Diario de viaje de un naturalista alrededor del mundo
  20. 1860
    Publicado 1940
    Libro
    A sacred almanac of the Aztecs : (Tonalamatl of the Codex borbonicus)
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