“…Treatment decisions for patients with LGG are directed toward improving upon the natural history while limiting treatment-associated toxiceffects. …”
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“…The natural history of schistosome infection in the mammalian host is determined by CD4(+) T helper responses mounted against different parasite life cycle stages. …”
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“…The modest stabilization compared to natural history data leaves open the possibility that longer studies may demonstrate benefit.…”
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“…Here, we analyse the natural history of a vast group of membrane-associated molecular systems in Bacteria and Archaea—the type IV filament (TFF) superfamily—that diversified in systems involved in flagellar or twitching motility, adhesion, protein secretion, and DNA uptake. …”
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“…Basal ganglia dysfunction does not account for important features of Tourette syndrome, including its natural history, male predominance, and the characteristic quality and distribution of tics. …”
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“…There is a long-standing natural history tradition describing interspecific diversity in these concentrations. …”
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“…An afternoon roundtable discussion focused on four key areas essential to advance research toward gene therapy clinical trials: trial design, dose projection from nonclinical to clinical studies, natural history, and regulatory considerations. In their comments, the 27 participants from academic centers, affected families, biotechnology and pharmaceutical companies, and the regulatory community highlighted a number of research priorities, including the following: systematic inventory of retrospective natural history studies and planning for a multicenter prospective study, development of large animal models, and evaluation of novel tests of functional vision in young children. …”
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“…Conflicting evidence from natural history studies and the widespread use of proper medical management including risk factors control, lowering-lipid drugs and strict control of arterial hypertension have reduced the incidence of strokes associated to asymptomatic carotid disease challenging established practice. …”
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“…In this Review, main aspects of the natural history and risk factors of the disease are summarized in children and adolescents. …”
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“…Background: Chronic inflammatory bowel diseases (IBDs) are gaining increasing attention, both because they can severely reduce the quantity and quality of life, and because the advent of monoclonal antibodies has profoundly changed the natural history of these diseases. In recent years, the concept of mucosal healing has assumed a certain importance, and there are more and more clinical and pharmacological trials that consider this parameter among their endpoints, so much so that it may soon be included among the desirable clinical outcomes of patients with IBD. …”
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“…CONCLUSIONS: With breast cancer natural history models and population screening data, we can estimate latent processes of tumor onset, tumor growth, and mammography screening sensitivity. …”
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“…With the help of these breast cancer natural history models, we can better understand the latent processes, and better study the effects of breast cancer screening.…”
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“…The hypothesis of oligometastases is that the treatment of a clinically limited number of distant metastases can change the natural history of stage IV breast cancer. The advance in the technology of stereotactic body radiation (SBRT) has made it more possible to offer a non-invasive, yet potentially disease-modifying, metastases-directed ablative treatment in place of surgery or a palliative radiation regimen. …”
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“…Study of Darwin's unpublished works, freely available on-line through the American Natural History Museum, reveals the origins of his thoughts on evolution.…”
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“…The aim of this paper is to highlight the natural history of oral cancer spread and how malignant infiltration can be accurately mapped. …”
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“…This article reviews the literature on the aetiology and natural history of the condition, and the common treatments provided. …”
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“…Better identification of dual diagnosis patients could lead to improvements in gait and incontinence following ventriculoperitoneal or lumboperitoneal shunting, even if the natural history of the other neurodegenerative disease remains unchanged.…”
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“…Responding to the urgent need to make biodiversity records broadly accessible, the natural history community turned to “the cloud.”…”
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“…A better understanding of the natural history of model organisms will increase their value as model systems and also keep them at the forefront of research. …”
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“…Substantial challenges in study design and methodology exist during clinical trial development to examine treatment response in patients with a rare disease, especially those with predominant central nervous system involvement and heterogeneity in clinical manifestations and natural history. Here we discuss crucial decisions which may significantly impact success of the study, including patient selection and recruitment, identification and selection of endpoints, determination of the study duration, consideration of control groups including natural history controls, and selection of appropriate statistical analyses. …”
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