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2301por Zhao, Di, Luo, Ming-hui, Pan, Jian-ke, Zeng, Ling-feng, Liang, Gui-hong, Han, Yan-hong, Liu, Jun, Yang, Wei-yi“…BACKGROUND: Tanezumab is a nerve growth factor monoclonal antibody that may regulate pain in hip or knee osteoarthritis (OA). …”
Publicado 2022
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2302“…Expression of p53, p21, nerve growth factor IB (Nur77), and ARHGEF9 was assessed by western blotting, and the effect of CHD1L silencing on gastric cancer cell proliferation, apoptosis, and migration was examined by MTT, flow cytometry, and wound healing assays, respectively. …”
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2303por Li, Li, Liu, Xin, Ge, Wenqiang, Chen, Chao, Huang, Yuqiong, Jin, Zilin, Zhan, Muouyang, Duan, Xiaoru, Liu, Xinxin, Kong, Yi, Jiang, Jian, Li, Xuemei, Zeng, Xin, Li, Fei, Xu, Shibin, Li, Man, Chen, Hongxiang“…Obvious proliferation and prolongation of nerve fibers and high expression of nerve growth factor (NGF) were observed in PsD and CB2R KO mice. …”
Publicado 2022
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2304por Meng, Fanqiang, Li, Hui, Feng, Haoran, Long, Huizhong, Yang, Zidan, Li, Jiatian, Wang, Yuqing, Xie, Dongxing“…BACKGROUND: We aimed to evaluate the efficacy and safety of biologic agents targeting three main cytokines, that is, nerve growth factor (NGF), interleukin-1 (IL-1), and tumor necrosis factor-α (TNF-α), for osteoarthritis (OA) treatment. …”
Publicado 2022
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2305por Shillo, Pallai, Yiangou, Yiangos, Donatien, Philippe, Greig, Marni, Selvarajah, Dinesh, Wilkinson, Iain D., Anand, Praveen, Tesfaye, Solomon“…We hypothesized that hypoxia-induced increase of blood vessels, which secrete algogenic substances including nerve growth factor (NGF), may expose their associated nociceptor fibers to a relative excess of algogens, thus leading to painful-DPN.…”
Publicado 2021
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2306por Gao, Xiufei, Yang, Zimei, Xu, Chuchu, Yu, Qinghong, Wang, Mengqian, Song, Jiaqing, Wu, Chunyu, Chen, Mingcang“…These significantly changed genes regulated DNA synthesis, chromosome alignment, microtubules and the cytoskeleton, cell movement, the cell cycle, cell necrosis, and apoptosis because they promoted G2/M DNA damage checkpoint regulation and p53 signaling, and because they inhibited integrin, hepatocyte growth factor (HGF), nerve growth Factor (NGF), and other tumor-promoting signaling pathways. …”
Publicado 2022
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2307por Shi, Chenyu, Xu, Song, Huang, Caiyun, Wang, Zijie, Wang, Wenhui, Ming, Dongxu, Yin, Xindi, Liu, Hu, Wang, Fenglai“…Compared with the LPS group, the concentration of neuropeptide Y (NPY), nerve growth factor (NGF), vasoactive intestinal peptide (VIP), substance P (SP), calcitonin gene-related peptide (CGRP), and brain-derived neurotropic factor (BDNF) in serum were decreased in PQQ treatment groups (P < 0.05). …”
Publicado 2022
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2308“…Neurological assessment was evaluated as well as serum levels of glial fibrillary acidic protein (GFAP), tumor necrosis factor-alpha (TNF-α), nerve growth factor (NGF), vascular endothelial growth factor (VEGF), tissue dopamine and oxidative markers. …”
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2309“…Data with myoinositol, daidzein, and with compounds that target oxidative stress, inflammation, Rac1, nerve growth factor, angiotensin II receptor, serotonin receptor, adenosine receptor, and soluble guanylyl cyclase are not conclusive yet, but some hold promise as potential treatments. …”
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2310por Walsh, David A., Boeri, Marco, Abraham, Lucy, Atkinson, Jo, Bushmakin, Andrew G., Cappelleri, Joseph C., Hauber, Brett, Klein, Kathleen, Russo, Leo, Viktrup, Lars, Turk, Dennis“…Attributes were based on known profiles of oral nonsteroidal anti‐inflammatory drugs, opioids and injected nerve growth factor inhibitors, the last of which were under clinical development at the time of the study. …”
Publicado 2022
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2311por Chen, Yuwen, Wang, Liang, You, Wenjun, Huang, Fei, Jiang, Yingzi, Sun, Li, Wang, Siye, Liu, Su“…Glasgow coma scale (GCS) and coma recovery scale-revised (CRS-R) scores were used to measure consciousness; the Rancho Los Amigos scale-revised (RLAS-R) score was used to assess cognitive impairment; the Stockholm computed tomography (CT) score, quantitative electroencephalography (QEEG), and biomarkers, including neuron-specific enolase (NSE), S100 calcium-binding protein beta (S100β), glial fibrillary acidic protein (GFAP), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and vascular endothelial growth factor (VEGF), were used to assess TBI severity. …”
Publicado 2022
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2312por Nadelmann, Jennifer B, Bunya, Vatinee Y, Ying, Gui-Shuang, Hua, Peiying, Massaro-Giordano, Mina“…Subjects were excluded if they did not have follow-up, underwent intraocular surgery prior to follow-up, received nerve growth factor treatments, or did not have a baseline examination with photography. …”
Publicado 2022
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2313por Xiang, Mengmeng, Wang, Yilun, Gao, Zhanyan, Wang, Jie, Chen, Qian, Sun, Zhan, Liang, Jun, Xu, Jinhua“…In addition, cytokines including beta nerve growth factor, basic fibroblast growth factor, IL-4, IL-6, interferon gamma-induced protein 10, monokine induced by interferon-gamma, MIP1b, stromal cell-derived factor-1 alpha, and tumor necrosis factor-alpha are suggested to be the consequences of SLE disease (Beta: 0.035, p = 0.014; Beta: 0.021, p = 0.032; Beta: 0.024, p = 0.013; Beta: 0.019, p = 0.042; Beta: 0.040, p = 0.005; Beta: 0.046, p = 0.001; Beta: 0.021, p = 0.029; Beta: 0.019, p = 0.045; Beta: 0.029, p = 0.048). …”
Publicado 2023
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2314“…Behavioral tests, including Morris water maze test (MWM), novel object recognition test (NORT), and fear conditioning test, were used to measure the cognitive function; ELISA and biochemical tests were used to determine the levels of interleukin (IL)-1β, IL-6, monocyte chemoattractant protein-1 (MCP-1), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), malondialdehyde (MDA), and glutathione peroxidase (GSH-Px) in the hippocampus of rats in each group, respectively; H&E staining was used to observe the pathological changes in the hippocampus; Western blot was used to examine the expression of toll-like receptor 4 (TLR4)/NF-κB pathway-related proteins and endoplasmic reticulum (ER) stress-related proteins in the hippocampus. …”
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2315por Rivera, Kevin O., Cuylear, Darnell L., Duke, Victoria R., O’Hara, Kelsey M., Zhong, Justin X., Elghazali, Nafisa A., Finbloom, Joel A., Kharbikar, Bhushan N., Kryger, Alex N., Miclau, Theodore, Marcucio, Ralph S., Bahney, Chelsea S., Desai, Tejal A.“…Here, we describe poly (ethylene glycol) dimethacrylate (PEGDMA)-based microparticles, in the shape of microrods, loaded with beta nerve growth factor (β-NGF) for the purpose of promoting fracture repair. …”
Publicado 2023
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2316por Li, Jiayi, Ge, Jianrong, Ran, Na, Zheng, Changwu, Fang, Yumeng, Fang, Danna, Yang, Qian, Ma, Yeling“…Furthermore, the results also indicated that global consideration of multiple inflammatory factors, such as CRP/IL-1β/IL-6 biomarker cluster in gestational 27–34 weeks, and the tumor necrosis factor/nerve growth factor (TNF/NGF) family during gestational 25–33 weeks, were potential biomarker clusters that specific for infectious PTB prediction. …”
Publicado 2023
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2317por Wang, Qiao, Wang, Huizhi, Meng, Wenjia, Liu, Chong, Li, Renpeng, Zhang, Moxuan, Liang, Kun, Gao, Yuan, Du, Tingting, Zhang, Jianguo, Han, Chunlei, Shi, Lin, Meng, Fangang“…In the present study, NONRATT023402.2 was overexpressed by injection of adeno-associated virus (AAV) in striatum of LID rats, and 48 potential target genes, including nerve growth factor receptor (NGFR) were screened using next-generation sequencing and target gene predictions. …”
Publicado 2023
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2318por Anyachor, Chidinma P., Orish, Chinna N., Ezejiofor, Anthonet N., Cirovic, Ana, Cirovic, Aleksandar, Ezealisiji, Kenneth M., Orisakwe, Orish E.“…Malondialdehyde (MDA), catalase (CAT), glutathione content (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), Brain Derived Neurotrophic Factor (BDNF), Nerve growth factor NGF, cyclo-oxygenase COX-2 and Acetylcholinesterase (AChE) were assayed using ELISA kits. …”
Publicado 2023
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2319por Fang, Peng, Liu, Xiaozhou, Qiu, Yang, Wang, Yang, Wang, Dongsheng, Zhao, Jianning, Ding, Hao, Bao, Nirong“…RESULTS: The results suggest a genetically predicted potential association between beta-nerve growth factor (βNGF), Interleukin-1-beta (IL-1β), and TNF-related apoptosis inducing ligand (TRAIL) with the risk of AS (OR: 2.17, 95% CI: 1.13-4.16; OR: 0.41, 95% CI: 0.18-0.95,; OR: 1.47, 95% CI: 1.02-2.13).Additionally, Interleukin-12p70 (IL-12p70), Interleukin-17 (IL-17), Interleukin-6 (IL-6), Interleukin-4 (IL-4), Stromal-cell-derived factor 1 alpha (SDF−1α), Macrophage inflammatory protein 1β (MIP1β), Monocyte chemoattractant protein-3 (MCP-3), Platelet-derived growth factor bb (PDGFbb), Granulocyte-colony stimulating factor (GCSF), Fibroblast growth factor basic (bFGF), TNF-related apoptosis inducing ligand (TRAIL), and Interferon-gamma (IFN -γ) are suggested as consequences of AS in genetically prediction.No evidence of horizontal pleiotropy or heterogeneity between the genetic variants was found (P>0.05), and a leave-one-out test confirmed the stability and robustness of this association. …”
Publicado 2023
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2320por Facer, Paul, Casula, Maria A, Smith, Graham D, Benham, Christopher D, Chessell, Iain P, Bountra, Chas, Sinisi, Marco, Birch, Rolfe, Anand, Praveen“…Reduction of TRPV1 levels in nerve fibres in diabetic neuropathy skin may result from the known decrease of nerve growth factor (NGF) levels. The role of TRPs in keratinocytes is unknown, but a relationship to changes in NGF levels, which is produced by keratinocytes, deserves investigation. …”
Publicado 2007
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