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21Publicado 1986“…Four mutant PC12 pheochromocytoma cell lines that are nerve growth factor (NGF)-nonresponsive (PC12nnr) have been selected from chemically mutagenized cultures by a double selection procedure: failure both to grow neurites in the presence of NGF and to survive in NGF-supplemented serum-free medium. …”
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22“…BACKGROUND: Nerve growth factor (NGF) is a neurotrophin that is increased in osteoarthritic joints of horses. …”
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23Publicado 1996“…We show that stathmin depletion prevents nerve growth factor (NGF)-stimulated differentiation of PC12 cells into sympathetic-like neurons although the expression of several NGF-inducible genes was not affected. …”
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24por Barthel, Christian, Yeremenko, Nataliya, Jacobs, Roland, Schmidt, Reinhold E, Bernateck, Michael, Zeidler, Henning, Tak, Paul-Peter, Baeten, Dominique, Rihl, Markus“…Here we investigated the presence of the corresponding nerve growth factors, with special focus on nerve growth factor (NGF). …”
Publicado 2009
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25por Hodeib, Abeer, El-Samad, Zeinab Abd, Hanafy, Hesham, El-Latief, Amani Abd, El-bendary, Amal, Abu-Raya, Azza“…INTRODUCTION: Neurogenic components, as neurotrophic factors and neuropeptides, are probably involved in the pathogenesis of atopic dermatitis (AD) with the neuroimmunocutaneous system as they modify the functions of immunoactive cells in the skin. Nerve growth factor (NGF) is the best-characterized member of the neurotrophin family. …”
Publicado 2010
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26por Steinle, Jena J“…Topical application of nerve growth factor (NGF) and adrenergic receptor pharmaceutics are currently in use for corneal ulcers and glaucoma. …”
Publicado 2010
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27“…A meta-analysis was performed to evaluate the efficacy and safety of nerve growth factor (NGF) in the treatment of Bell’s palsy. …”
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28“…The discovery of nerve growth factor (NGF) and its interaction with tropomyosin receptor kinase A (trkA) have been well characterized as important mediators of pain initiation and maintenance, and pharmacotherapies targeting this pathway have the potential to be considered promising methods in the treatment of a variety of nociceptive and neuropathic pain conditions. …”
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29“…Nerve growth factor (NGF) is a key regulator of the development and differentiation of neuronal and non-neuronal cells. …”
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30“…In this review, we present the role of nerve growth factor (NGF) in pain generation, relationship between NGF and OA pain, and pathogenic factors (interleukin-1β, transforming growth factor-β1, mechanical loading, and adipokines) involved in OA development. …”
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31“…In recent years, nerve growth factor (NGF) and the NGF receptor have become potential therapeutic targets in the treatment of acute and chronic pain states. …”
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32por Morgentaler, AbrahamEnlace del recurso
Publicado 2018
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33“…Since its discovery, nerve growth factor (NGF) has long occupied a critical role in developmental and adult neuro-biology for its many important regulatory functions on the survival, growth and differentiation of nerve cells in the peripheral and central nervous system. …”
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34por Mufson, Elliott J., Counts, Scott E., Ginsberg, Stephen D., Mahady, Laura, Perez, Sylvia E., Massa, Stephen M., Longo, Frank M., Ikonomovic, Milos D.“…The current review summarizes the pathobiology of nerve growth factor (NGF) and its cognate receptors during the progression of Alzheimer’s disease (AD). …”
Publicado 2019
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35“…Since the 1980s, the development of a pharmacology based on nerve growth factor (NGF) has been postulated for the therapy of Alzheimer’s disease (AD). …”
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36“…The neurotrophin field has always been dominated by the neurocentric view that the primary target of these molecules must be neurons: this holds true even for the Nerve Growth Factor (NGF), which owes its popularity in the neuroscience community to its trophic and tropic activity towards sensory and sympathetic neurons in the peripheral nervous system, and cholinergic neurons in the CNS. …”
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37por Lisi, Lucia, Marinelli, Silvia, Ciotti, Gabriella Maria Pia, Pizzoferrato, Michela, Palmerio, Federica, Chiavari, Marta, Cattaneo, Antonino, Navarra, Pierluigi“…Previous studies in the rat suggest that microglial cells represent a potential druggable target for nerve growth factor (NGF) in the brain. The painless human Nerve Growth Factor (hNGFp) is a recombinant mutated form of human nerve growth factor (hNGF) that shows identical neurotrophic and neuroprotective properties of wild-type NGF but displays at least 10-fold lower algogenic activity. …”
Publicado 2022
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38Publicado 1990“…We have found a regional distribution of IL 1 beta mRNA and IL 1 activity in the normal adult rat brain, which reveals at least partially a colocalization with nerve growth factor (NGF). The predominantly neuronal signal patterns were found over the granule cells of the dentate gyrus, the pyramidal cells of the hippocampus, the granule cells of the cerebellum, the granule and periglomerular cells of the olfactory bulb, and over dispersed cells of the ventromedial hypothalamus and of the frontal cortex. …”
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39Publicado 1985“…The binding of nerve growth factor (NGF) to specific cell surface receptors initiates a variety of effects that lead to the morphological and biochemical differentiation of clonal pheochromocytoma, PC12, cells. …”
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40Publicado 1986“…Nerve growth factor (NGF) is necessary for the development of sympathetic and some sensory neurons. …”
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