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1541por Di Paola, Rosanna, Fusco, Roberta, Gugliandolo, Enrico, Crupi, Rosalia, Evangelista, Maurizio, Granese, Roberta, Cuzzocrea, Salvatore“…The treated group displayed a smaller cyst diameter, with improved fibrosis score and mast cell number decrease. m(PEA/PLD) administration decreased angiogenesis (vascular endothelial growth factor), nerve growth factor, intercellular adhesion molecule, matrix metalloproteinase 9 expression, and lymphocyte accumulation. m(PEA/PLD) treatment also reduced peroxynitrite formation, (poly-ADP)ribose polymerase activation, IkBα phosphorylation and nuclear facor-kB traslocation in the nucleus. …”
Publicado 2016
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1542por Chuang, Jian-Ying, Kao, Tzu-Jen, Lin, Shu-Hui, Wu, An-Chih, Lee, Pin-Tse, Su, Tsung-Ping, Yeh, Shiu-Hwa, Lee, Yi-Chao, Wu, Chung-Che, Chang, Wen-Chang“…The upregulation of Sp1 transcriptional activity induced by the treatment with nerve growth factor (NGF) led to an increase in Znf179 levels, which further protected cells against H(2)O(2)-induced damage. …”
Publicado 2016
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1543por Dobson, Claire L., Devine, Paul W. A., Phillips, Jonathan J., Higazi, Daniel R., Lloyd, Christopher, Popovic, Bojana, Arnold, Joanne, Buchanan, Andrew, Lewis, Arthur, Goodman, Joanne, van der Walle, Christopher F., Thornton, Peter, Vinall, Lisa, Lowne, David, Aagaard, Anna, Olsson, Lise-Lotte, Ridderstad Wollberg, Anna, Welsh, Fraser, Karamanos, Theodoros K., Pashley, Clare L., Iadanza, Matthew G., Ranson, Neil A., Ashcroft, Alison E., Kippen, Alistair D., Vaughan, Tristan J., Radford, Sheena E., Lowe, David C.“…We show that the human monoclonal antibody, MEDI1912, selected against nerve growth factor binds with picomolar affinity, but undergoes reversible self-association and has a poor pharmacokinetic profile in both rat and cynomolgus monkeys. …”
Publicado 2016
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1544por Adams, Kenneth W., Kletsov, Sergey, Lamm, Ryan J., Elman, Jessica S., Mullenbrock, Steven, Cooper, Geoffrey M.“…Epidermal growth factor (EGF) activates transient ERK signaling in PC12 cells that lasts 30–60 min, which in turn promotes proliferation; nerve growth factor (NGF) activates more sustained ERK signaling that lasts 4–6 h, which in turns induces neuronal differentiation. …”
Publicado 2017
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1545por Asiedu, Marina N., Han, Chongyang, Dib-Hajj, Sulayman D., Waxman, Stephen G., Price, Theodore J., Dussor, Gregory“…PT1, a structurally dissimilar AMPK activator that reduces nerve growth factor (NGF) -induced hyperexcitability, has no influence on AP firing in TG neurons upon acute application. …”
Publicado 2017
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1546por Nakamura, Tomoe Y., Nakao, Shu, Nakajo, Yukako, Takahashi, Jun C., Wakabayashi, Shigeo, Yanamoto, Hiroji“…Expression of brain-derived neurotrophic factor (BDNF; a key regulator of memory function) and dopamine was significantly reduced in the Ncs1(-/-) mouse brain, without changes in the levels of glial cell-line derived neurotrophic factor or nerve growth factor. Although there were no gross structural abnormalities in the hippocampi of Ncs1(-/-) mice, electron microscopy analysis revealed that the density of large dense core vesicles in CA1 presynaptic neurons, which release BDNF and dopamine, was decreased. …”
Publicado 2017
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1547por Landry, Jasmine, Martinov, Tijana, Mengistu, Hanna, Dhanwada, Jyothi, Benck, Charles J., Kline, Jaclyn, Boo, Beebie, Swanson, Linnea, Tonc, Elena, Daughters, Randy, Fife, Brian T., Chatterjea, Devavani“…Allergic sites were characterized by mast cell accumulation, sensory hyper-innervation and infiltration of regulatory CD4(+)CD25(+)FoxP3(+) T cells as well as localized early increases in transcripts encoding Nerve Growth Factor and nerve-mast cell synapse marker Cell Adhesion Molecule 1. …”
Publicado 2017
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1548por Shaikh, Samiha S., Chen, Ya‐Chun, Halsall, Sally‐Anne, Nahorski, Michael S., Omoto, Kiyoyuki, Young, Gareth T., Phelan, Anne, Woods, Christopher Geoffrey“…Each mutation was systematically analyzed for TRKA glycosylation states, intracellular and cell membrane expression patterns, nerve growth factor stimulated TRKA autophosphorylation, TRKA‐Y496 phosphorylation, PLCγ activity, and neurite outgrowth. …”
Publicado 2016
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1549por Duan, Lian, Fang, Fang, Fu, Wanlei, Fang, Zhenqiang, Wang, Hui, Yu, Shicang, Tang, Zili, Liu, Zhenqi, Zheng, Hongting“…Acetaldehyde dehydrogenase 1(ALDH1), CD44, CD133, Nestin, Nerve growth factor receptor (NGFR), and Sex determining region y-box 9(SOX9) staining were positive. …”
Publicado 2017
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1550por Inoue, Shogo, Miyamoto, Katsutoshi, Shinmei, Shunsuke, Shoji, Koichi, Teishima, Jun, Sentani, Kazuhiro, Yasui, Wataru, Matsubara, Akio“…Immunohistochemical analysis revealed that the nine fully treated rats had venous sinus-like structures and quantitative reverse transcription polymerase chain reaction analysis of extracts from their alginate gel sponge sheets revealed that the amounts of mRNA encoding the nerve growth factor (NGF), and vascular endothelial growth factor (VEGF) were significantly higher than those for rats treated with alginate gel sheets without cell supplementation (NGF: P = 0.0309; VEGF: P < 0.0001). …”
Publicado 2017
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1551“…Curcumin (CRM) and nerve growth factor (NGF) were entrapped in liposomes (LIP) with surface wheat germ agglutinin (WGA) to downregulate the phosphorylation of kinases in Alzheimer’s disease (AD) therapy. …”
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1552“…Nerve growth factor (NGF) promotes the survival and differentiation of neurons. …”
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1553“…NTS-SCs are able to secrete some neurotrophic Such as nerve growth factor and glia-derived neurotrophic factor. …”
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1554por Yu, Lilei, Wang, Menglong, Hu, Dan, Huang, Bing, Zhou, Liping, Zhou, Xiaoya, Wang, Zhuo, Wang, Songyun, Jiang, Hong“…Furthermore, decreased nerve growth factor, decreased c-fos and increased sympathetic neuron apoptosis were found in the LSG after A-803467 injection. …”
Publicado 2017
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1555por Knezevic, Nebojsa Nick, Mandalia, Shane, Raasch, Jennifer, Knezevic, Ivana, Candido, Kenneth D“…Another new drug in development for low back pain without radiculopathy is a subcutaneous monoclonal antibody acting as nerve growth factor called tanezumab. Finally, we discuss how platelet-rich plasma and stem cells are being studied for the treatment of low back pain. …”
Publicado 2017
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1556“…CONCLUSION: The results showed that chlorogenic acid could protect the focal cerebral ischemia reperfusion injury rat models by adjusting the inflammatory factor, hypoxia factor and nerve growth factor.…”
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1557por Suresh, Raviraj V., Lingaiah, Kusuma, Veerappa, Avinash M., Ramachandra, Nallur B.“…RESULTS: Forty three NDJ genes were found under CNV burden; IPA (Ingenuity Pathway Analysis) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis of CNV in meiotic recombination genes revealed a significant role of breast cancer gene 1, amyloid protein precursor, mitogen-activated protein kinase and nerve growth factor as key molecular players involved in causing aneuploidy. …”
Publicado 2017
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1558por Lopes, Douglas M., Denk, Franziska, Chisholm, Kim I., Suddason, Tesha, Durrieux, Camille, Thakur, Matthew, Gentry, Clive, McMahon, Stephen B.“…In addition, we show that Mctp5Cre-iDTR mice display normal levels of mechanical hypersensitivity after local injection of nerve growth factor (NGF), a factor well characterised to produce peripheral sensitisation and for being upregulated upon injury and inflammation. …”
Publicado 2017
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1559por Song, Jialin, Li, Xueyang, Li, Yingli, Che, Junyi, Li, Xiaoming, Zhao, Xiaotian, Chen, Yinghui, Zheng, Xianyou, Yuan, Weien“…The upregulation of miR-221/222 in SCs promoted the expression of nerve growth factor and myelin basic protein in vitro. The mouse sciatic nerve crush injury model was used to evaluate the effectiveness of PDAPEI/miR-221/222 complexes for nerve regeneration in vivo. …”
Publicado 2017
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1560“…Recently, this OIF has been identified from SP as a neurotrophin, the β subunit of nerve growth factor (β-NGF). β-NGF is well known as promoting neuron survival and growth, but in this case, it appears to induce ovulation through an endocrine mode of action. …”
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