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Mostrando 181 - 200 Resultados de 4,546 Para Buscar '"nonsense"', tiempo de consulta: 0.20s Limitar resultados
  1. 181
    “…Nonsense-mediated mRNA decay (NMD) is responsible for the degradation of mRNAs with a premature termination codon (PTC). …”
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    Targeting nonsense-mediated mRNA decay in colorectal cancers with microsatellite instability
  2. 182
    “…The nonsense mutation was not found in several quail strains with non-yellowish plumage. …”
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    Nonsense mutation in PMEL is associated with yellowish plumage colour phenotype in Japanese quail
  3. 183
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    Nonsense mutation in CFAP43 causes normal-pressure hydrocephalus with ciliary abnormalities
  4. 184
    “…A heterozygous private nonsense variant, c.487C>T, was found in the SIX6 gene. …”
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    A SIX6 Nonsense Variant in Golden Retrievers with Congenital Eye Malformations
  5. 185
    “…Nonsense‐mediated mRNA decay (NMD) was originally coined to define a quality control mechanism that targets mRNAs with truncated open reading frames due to the presence of a premature termination codon. …”
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    Nonsense‐mediated mRNA decay: novel mechanistic insights and biological impact
  6. 186
    “…Efforts to develop treatments for diseases caused by nonsense mutations have focused on identification of small molecules that promote translational read-through of messenger RNAs (mRNAs) harboring nonsense stop codons to produce full-length proteins. …”
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    Targeting Translation Termination Machinery with Antisense Oligonucleotides for Diseases Caused by Nonsense Mutations
  7. 187
    “…A nonsense mutation is a substitutive mutation in a DNA sequence that causes a premature termination during translation and produces stalled proteins, resulting in dysfunction of a gene. …”
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    CRISPR-Pass: Gene Rescue of Nonsense Mutations Using Adenine Base Editors
  8. 188
    por Zhao, Boyang, Pritchard, Justin R.
    Publicado 2019
    “…However, expression of this antigenic diversity is potentially regulated by Nonsense Mediated Decay (NMD) and NMD has been shown to be of variable efficiency in cancers. …”
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    Evolution of the nonsense-mediated decay pathway is associated with decreased cytolytic immune infiltration
  9. 189
    “…This identifies Dbp5/DDX19 as a possible potent drug target for nonsense suppression therapy. Neurodegenerative diseases and cancer are caused in many cases by the loss of a gene product, because its mRNA contained a premature termination codon (PTC) and is thus eliminated through the nonsense mediated decay (NMD) pathway, which is described in the second half of this review. …”
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    Dbp5/DDX19 between Translational Readthrough and Nonsense Mediated Decay
  10. 190
    “…Several types of thalassemia (including β(0)39-thalassemia) are caused by nonsense mutations in genes controlling globin production, leading to premature translation termination and mRNA destabilization mediated by the nonsense mediated mRNA decay. …”
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    Screening Readthrough Compounds to Suppress Nonsense Mutations: Possible Application to β-Thalassemia
  11. 191
    “…Nonsense mutations can be corrected by molecules with nonsense mutation readthrough activity. …”
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    2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations
  12. 192
    “…Previously, we isolated nonsense mutations sup35-n and proposed that the viability of such mutants can be explained by readthrough of the premature stop codon. …”
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    Nonsense Mutations in the Yeast SUP35 Gene Affect the [PSI(+)] Prion Propagation
  13. 193
    “…A genetic screen in this sensitized background uncovered how nonsense-mediated decay (NMD), a host RNA quality control mechanism, recognizes and eliminates PVX RNAs with internal termination codons and long 3′ UTRs. …”
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    Nonsense-Mediated Decay Serves as a General Viral Restriction Mechanism in Plants
  14. 194
    “…We introduced to yeast cells an additional copy of the SUP35 gene with mutated amyloidogenic domain and observed that some nonsense mutations increased the incidence of prions by several orders of magnitude. …”
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    Dangerous Stops: Nonsense Mutations Can Dramatically Increase Frequency of Prion Conversion
  15. 195
    “…Recently, missense and nonsense dominant variants in the PODXL gene have been associated with focal segmental glomerulosclerosis (FSGS), a leading cause of nephrotic syndrome and kidney failure. …”
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    Atypical focal segmental glomerulosclerosis associated with a new PODXL nonsense variant
  16. 196
    “…We evaluated the efficacy of combinations of drugs targeting at various levels the effects of nonsense mutations: SMG1i to protect CFTR mRNA from nonsense-mediated decay (NMD), G418 and ELX-02 for readthrough, VX-809 and VX-445 to promote protein maturation and function, PTI-428 to enhance CFTR protein synthesis. …”
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    Comprehensive Analysis of Combinatorial Pharmacological Treatments to Correct Nonsense Mutations in the CFTR Gene
  17. 197
    “…A heterozygous nonsense variant in the TIGIT gene was identified in a patient in Thailand who had severe COVID-19, resulting in lower TIGIT expression in T cells. …”
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    TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand
  18. 198
    por Noring, Christoffer, Deeleman, Pablo
    Publicado 2017
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    Learning Angular: a no-nonsense guide to building real-world apps with Angular 5
  19. 199
    por Zanesco, Bella
    Publicado 2018
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    Smart girls screw up too: the no-nonsense guide to creating the life you want
  20. 200
    “…In this study, triamterene, an FDA-approved, antihypertensive diuretic, was found to suppress translation termination at a nonsense mutation associated with MPS I-H. Triamterene rescued enough α-L-iduronidase function to normalize glycosaminoglycan storage in cell and animal models. …”
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    Triamterene Functions as an Effective Nonsense Suppression Agent for MPS I-H (Hurler Syndrome)
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