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Mostrando 41 - 60 Resultados de 4,546 Para Buscar '"nonsense"', tiempo de consulta: 0.14s Limitar resultados
  1. 41
    “…Introduction: Dystrophinopathy is a rare, severe muscle disorder, and nonsense mutations are found in 13% of cases. Ataluren was developed to enable ribosomal readthrough of premature stop codons in nonsense mutation (nm) genetic disorders. …”
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    Ataluren treatment of patients with nonsense mutation dystrophinopathy
  2. 42
    “…The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs) but also regulates the abundance of a large number of cellular RNAs. …”
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    Mechanism and regulation of the nonsense-mediated decay pathway
  3. 43
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    Stacking Chairs: Local Sense and Global Nonsense
  4. 44
    “…Nonsense-mediated decay (NMD) is a host RNA control pathway that removes aberrant transcripts with long 3’ untranslated regions (UTRs) due to premature termination codons (PTCs) that arise through mutation or defective splicing. …”
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    RNA virus evasion of nonsense-mediated decay
  5. 45
    “…The interaction with others highlighted as significant could be about doing something fun, talking nonsense or kidding around, and hence not at all about making sense of something—a kind of important nonsense. …”
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    Nothing matters: the significance of the unidentifiable, the superficial and nonsense
  6. 46
    “…Nonsense mutations often result from single nucleotide substitutions that change a sense codon (coding for an amino acid) to a nonsense or premature termination codon (PTC) within the coding region of a gene. …”
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    Suppression of Nonsense Mutations by New Emerging Technologies
  7. 47
    por Werthner, Hannes
    Publicado 2021
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    From absolute nonsense to the world’s operating system
  8. 48
    “…BACKGROUND: About 11% of all human genetic diseases are caused by nonsense mutations that generate premature translation termination codons (PTCs) in messenger RNAs (mRNA). …”
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    Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations
  9. 49
    “…Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and selectively degrades mRNAs carrying premature termination codons (PTCs). …”
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    Resistance of mRNAs with AUG-proximal nonsense mutations to nonsense-mediated decay reflects variables of mRNA structure and translational activity
  10. 50
    por Olsson, Mikael
    Publicado 2013
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    Build a profitable online business: the no-nonsense guide
  11. 51
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    No-nonsense physicist: an overview of Gabriele Giuliani’s work and life
  12. 52
    por Copeland, Paul R
    Publicado 2005
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    Making sense of nonsense: the evolution of selenocysteine usage in proteins
  13. 53
    “…Novel introns are more likely to encode a premature termination codon (PTC), indicating that nonsense-mediated decay (NMD) functions as a backup for weak splicing of new introns. …”
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    Nonsense-Mediated Decay Enables Intron Gain in Drosophila
  14. 54
    por Trinkle-Mulcahy, Laura
    Publicado 2009
    “…One of the key quality control mechanisms put in place to recognize and eliminate these transcripts before they can be translated into faulty proteins is nonsense-mediated decay. Proteins involved in nonsense-mediated decay are highly conserved across species from plants to humans, and recent studies in Arabidopsis thaliana reveal both intriguing similarities and differences in the mechanisms employed to carry it out.…”
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    Aberrant mRNA transcripts and nonsense-mediated decay
  15. 55
    “…In many eukaryotes, messenger RNAs with premature termination codons are destroyed by a process called “nonsense-mediated decay”, which requires the RNA helicase Upf1 and also, usually, an interacting factor, Upf2. …”
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    Is There a Classical Nonsense-Mediated Decay Pathway in Trypanosomes?
  16. 56
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    Hemispheric Asymmetries in Speech Perception: Sense, Nonsense and Modulations
  17. 57
    por Wilke, Claus O.
    Publicado 2011
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    Transcriptional Robustness Complements Nonsense-Mediated Decay in Humans
  18. 58
    por Shao, Ada, Wilkinson, Miles F
    Publicado 2014
    “…The chemical inhibitor identified by Bhuvanagiri et al perturbs Nonsense-Mediated RNA Decay (NMD), a RNA surveillance pathway that targets mRNAs harboring premature termination codons (PTCs) for degradation (Kervestin & Jacobson, 2012).…”
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    Suppressing nonsense—a surprising function for 5-azacytidine
  19. 59
    “…We demonstrate that naturally occurring cancer-causing APC (adenomatous polyposis coli) nonsense mutants which escape nonsense-mediated mRNA decay (NMD) are repressed by miRNA-mediated surveillance. …”
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    MicroRNA-mediated repression of nonsense mRNAs
  20. 60
    “…Nonsense-mediated RNA decay (NMD) selectively degrades mutated and aberrantly processed transcripts that contain premature termination codons (PTC). …”
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    Inhibition of nonsense-mediated RNA decay by ER stress
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