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Mostrando 841 - 860 Resultados de 4,546 Para Buscar '"nonsense"', tiempo de consulta: 0.27s Limitar resultados
  1. 841
    por González de León, Ulalume
    Publicado 1980
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    Plagio II
  2. 842
    por Bhabha, Homi K., 1949-
    Publicado 1994
    Tabla de Contenidos: “…Articulating the archaic: cultural difference and colonial nonsense --…”
    Libro
    The location of culture /
  3. 843
    Tabla de Contenidos:
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    The flight from science and reason /
  4. 844
    “…Low molecular weight compounds that induce readthrough of nonsense mutations offer a new means of treating patients with genetic disorders or cancers resulting from nonsense mutations. …”
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    The nucleoside analog clitocine is a potent and efficacious readthrough agent
  5. 845
    “…Nonsense mutations introduce premature termination codons and underlie 11% of genetic disease cases. …”
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    Novel small molecules potentiate premature termination codon readthrough by aminoglycosides
  6. 846
    “…IB3.1 CF cells with a nonsense mutation were treated with caffeine to attenuate the Nonsense-Mediated mRNA Decay (NMD) activity and thus enhance the stability of the nonsense (ns)-CFTR-mRNA to be targeted by Ataluren. …”
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    Caffeine boosts Ataluren's readthrough activity
  7. 847
    “…BACKGROUND: We aimed to provide a set of previously reported PAH‐associated missense and nonsense variants, and evaluate the pathogenicity of those variants. …”
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    Exome data clouds the pathogenicity of genetic variants in Pulmonary Arterial Hypertension
  8. 848
    “…A limitation of nonsense suppression is that nonsense-mediated decay (NMD) degrades PTC-containing RNA transcripts. …”
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    RNA-based therapies in animal models of Leber congenital amaurosis causing blindness
  9. 849
    “…Mice carrying xenograft tumors with nonsense PTEN mutant displayed significantly shorter survival. …”
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    Combined PTEN Mutation and Protein Expression Associate with Overall and Disease-Free Survival of Glioblastoma Patients()()
  10. 850
    “…Using genetic and biochemical methods, we showed that [SWI(+)] is the key determinant of this nonsense suppression, whereas [PIN(+)] does not cause nonsense suppression by itself but strongly enhances the effect of [SWI(+)]. …”
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    Interaction of Prions Causes Heritable Traits in Saccharomyces cerevisiae
  11. 851
    por Muto, Hiroyuki
    Publicado 2021
    “…People can mentally rotate objects that resemble human bodies more efficiently than nonsense objects in the same/different judgment task. …”
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    Correlational Evidence for the Role of Spatial Perspective-Taking Ability in the Mental Rotation of Human-Like Objects
  12. 852
    por Michorowska, Sylwia
    Publicado 2021
    “…Around 12% of hereditary disease-causing mutations are in-frame nonsense mutations. The expression of genes containing nonsense mutations potentially leads to the production of truncated proteins with residual or virtually no function. …”
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    Ataluren—Promising Therapeutic Premature Termination Codon Readthrough Frontrunner
  13. 853
    “…OBJECTIVE: Nonsense mutations account for 5–70% of all genetic disorders. …”
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    Mice homozygous for c.451C>T mutation in Cln1 gene recapitulate INCL phenotype
  14. 854
    “…In this study, we investigated the therapeutic potential of the nonsense codon read-through-inducing drug, PTC124, in treating PXE. …”
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    Premature Termination Codon Read-Through in the ABCC6 Gene: Potential Treatment for Pseudoxanthoma Elasticum
  15. 855
    “…Recent studies has shown that proteins interacting with these release factors can modulate the efficiency of nonsense codon readthrough. RESULTS: We have isolated a nonessential yeast gene, which causes suppression of nonsense mutations, being in a multicopy state. …”
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    Itt1p, a novel protein inhibiting translation termination in Saccharomyces cerevisiae
  16. 856
    por Hwang, Jungwook, Kim, Yoon Ki
    Publicado 2013
    “…The faulty transcripts harboring PTC are subject to nonsense-mediated mRNA decay (NMD), nonsense-mediated translational repression (NMTR), nonsense-associated alternative splicing (NAS), or nonsense-mediated transcriptional gene silencing (NMTGS). …”
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    When a ribosome encounters a premature termination codon
  17. 857
    por Lear, Edward, 1812-1888
    Publicado 1984
    Libro
    Disparatario
  18. 858
    Publicado 2016
    “…OBJECTIVE: To construct human coagulation factor Ⅸ mini-gene (Mini-hF9) and some nonsense mutants, detect the levels of the Mini-hF9 mRNA, and analyze the molecular mechanism of microRNA125 regulating F9 gene with nonsense mutation. …”
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    microRNA125对无义突变的人凝血因子Ⅸ基因调控的分子机制
  19. 859
    “…Nonsense mutations turn a coding (sense) codon into an in-frame stop codon that is assumed to result in a truncated protein product. …”
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    Analysis of Stop Codons within Prokaryotic Protein-Coding Genes Suggests Frequent Readthrough Events
  20. 860
    “…The present study aimed to identify tumour suppressor genes inactivated by nonsense mutation and deletion in gastric cancer by means of GINI (gene identification by nonsense mediated decay inhibition) and whole genome copy number analysis. …”
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    NMD inhibition fails to identify tumour suppressor genes in microsatellite stable gastric cancer cell lines
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