“…METHODS: Firstly, we downloaded the GC and glycolysis-related microarray datasets from TCGA and MSigDB databases and took the intersection to screen out the transcription factor LHX9 that regulates GC glycolytic metabolic reprogramming. …”
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“…Prediction models were developed using combinations of the following variable groups: (1) Non-imaging: age/sex/tumor-location/tumor-morphology/CRT-surgery interval (2) Basic staging: cT-stage/cN-stage/mesorectal fascia involvement, derived from (2a) original staging reports, or (2b) expert re-evaluation (3) Advanced staging: variables from 2b combined with cTN-substaging/invasion depth/extramural vascular invasion/tumor length (4) Quantitative imaging: tumour volume + first-order histogram features (from T2W-MRI and DWI/ADC) Models were developed with data from 6 centers (n = 412) using logistic regression with the Least Absolute Shrinkage and Selector Operator (LASSO) feature selection, internally validated using repeated (n = 100) random hold-out validation, and externally validated using data from 3 centers (n = 97). …”
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“…The current study investigated this question by exposing aviators to varying levels of oxygen while carrying out simulated flight tasks. The aviators’ ANS responses were measured throughout the nearly two hours of trials. …”
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“…The process of establishing cancer models in mice has turned out to be challenging, since little research focuses on evaluating which factors impact engraftment success. …”
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“…RESULTS: A total of 176 out of 262 (67.2%) patients had Cdiff32 and microbiota data (119 RBL, 57 Placebo) in PUNCH CD3. …”
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“…Molecular signatures and candidate markers for PCC were developed using gene set enrichment analysis (GSEA) and machine learning, including random forest (RF) and support vector machine (SVM) methods. RESULTS: Out of the 5289 SARS-CoV-2 positive Military Health System beneficiaries enrolled in EPICC, 814 participants had at least one sample with blood transcriptomic profiling data. …”
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“…RESULTS: PDs from 34 unique programs who had administered the Core Curriculum to an estimated 405 ID fellows responded to the survey, out of the 159 institutions invited (21.4%). Most represented adult programs which had administered the curriculum for at least 2 years (Table 1). …”
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“…Against Burkholderia cepacia species complex, CFDC was the most potent agent tested, with MIC(50) and MIC(90) values of 0.06 and 0.5 µg/mL, and 156 out of 160 isolates inhibited at ≤4 µg/mL. None of the comparator agents showed >90% susceptibility against these isolates (Table). …”
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“…RESULTS: The original Carbapenem-Serratia study had 73 out of 128 patients who met the inclusion criteria (Figure 1). …”
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“…Chi Square and Mann-Whitney U tests were computed using SPSS statistical package. RESULTS: 73 out of 128 patients were included in the study after applying exclusion criteria (Figure 1). …”
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“…Then, the testes and spermatozoa of each mouse were collected to investigate the effects of BPA on male fertility. IVF was carried out using the cumulus–oocyte complexes from female hybrid B6D2F1/CrljOri mice (n = 3) between the ages of eight and twelve weeks. …”
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“…Luciferase reporter tests were carried out to verify molecular adhesion. Utilizing RT-qPCR, MTT, and a colony formation assay, the functional effects of NOX4 genetic mutation in CRISPR-excision, CRISPR-HDR, and CRISPR du-HITI knockdown cell lines of breast cancer were verified. …”
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“…The analytical solution, as absolute worst case, points out that resonators with a small product of inductance volume and quality factor (Q V(ind )< 2 cm(3)) are definitely save. …”
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“…However, should it be found subsequently that anaphylatoxins can be formed in this way, it seems unlikely that they are formed from the sensitizer or amboceptor as matrix, since this was not specifically adsorbed out of concentrated serum by the kaolin in our experiments. …”
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“…Intratracheal injection is perhaps better under the conditions mentioned than the intravenous route, for the surface veins cannot always be entered with promptness and certainty even under fairly normal conditions, and in cases of cardiac weakness the difficulties will be measurably increased, while an intratracheal injection can be carried out with ease. Moreover, it is legitimate to expect that some absorption will take place from the lung alveoli as long as the heart-lung circulation persists, no matter how feebly, and that thus some of the drug will reach the heart to act on this structure itself more promptly perhaps than when the drug is administered successfully through surface veins. …”
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“…Finally, the interest that the results of these experiments may have in connection with the question of function in tumor tissue should be pointed out. To those who hold that tumor lacks the capacity for physiological function, the adenomata of the thyroid could not be consistently regarded as tumors. …”
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“…The experiments presented in this paper brought out the following facts. Intramuscular injections of sodium oxalate into rabbits in doses of 0.18 and 0.2 gm. proved to be invariably fatal, death generally occurring in a comparatively short time. …”
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“…It is of interest to point out the similarities in the reaction of somatic agglutinin and precipitin. …”
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“…The striking fact brought out in the present study is the variety of responses to inoculation which animals of the same species may manifest. …”
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“…This fact has again been clearly brought out in the recent studies of Bruno Lange and his associates (3), who have shown that although guinea pigs may occasionally be infected by way of the mouth with quantities as low as 0.000,001 mg. of virulent tubercle bacilli they often escape infection even when fed 0.1 mg. or more. …”
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