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  1. 366141
    por Fleuren, Lucas M., Dam, Tariq A., Tonutti, Michele, de Bruin, Daan P., Lalisang, Robbert C. A., Gommers, Diederik, Cremer, Olaf L., Bosman, Rob J., Rigter, Sander, Wils, Evert-Jan, Frenzel, Tim, Dongelmans, Dave A., de Jong, Remko, Peters, Marco, Kamps, Marlijn J. A., Ramnarain, Dharmanand, Nowitzky, Ralph, Nooteboom, Fleur G. C. A., de Ruijter, Wouter, Urlings-Strop, Louise C., Smit, Ellen G. M., Mehagnoul-Schipper, D. Jannet, Dormans, Tom, de Jager, Cornelis P. C., Hendriks, Stefaan H. A., Achterberg, Sefanja, Oostdijk, Evelien, Reidinga, Auke C., Festen-Spanjer, Barbara, Brunnekreef, Gert B., Cornet, Alexander D., van den Tempel, Walter, Boelens, Age D., Koetsier, Peter, Lens, Judith, Faber, Harald J., Karakus, A., Entjes, Robert, de Jong, Paul, Rettig, Thijs C. D., Arbous, Sesmu, Vonk, Sebastiaan J. J., Fornasa, Mattia, Machado, Tomas, Houwert, Taco, Hovenkamp, Hidde, Noorduijn-Londono, Roberto, Quintarelli, Davide, Scholtemeijer, Martijn G., de Beer, Aletta A., Cina, Giovanni, Beudel, Martijn, Herter, Willem E., Girbes, Armand R. J., Hoogendoorn, Mark, Thoral, Patrick J., Elbers, Paul W. G.
    Publicado 2021
    “…Within legal and ethical boundaries, data are available to clinicians and researchers. RESULTS: Out of the 81 intensive care units in the Netherlands, 66 participated in the collaboration, 47 have signed the data sharing agreement, and 35 have shared their data. …”
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    Online Artículo Texto
    The Dutch Data Warehouse, a multicenter and full-admission electronic health records database for critically ill COVID-19 patients
  2. 366142
    “…Many organizations and individuals want to ensure that medicines are developed to meet real patient needs and to address what is most important to patients. Finding out what patients need and what patients want requires good patient engagement, but knowing how to do patient engagement is not always clear. …”
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    Online Artículo Texto
    Co-creation of practical “how-to guides” for patient engagement in key phases of medicines development—from theory to implementation
  3. 366143
    por Liu, Jun, Li, Dan-Dan, Dong, Wei, Liu, Yu-Qi, Wu, Yang, Tang, Da-Xuan, Zhang, Fu-Chun, Qiu, Meng, Hua, Qi, He, Jing-Yu, Li, Jun, Du, Bai, Du, Ting-Hai, Niu, Lin-Lin, Jiang, Xue-Jun, Cui, Bo, Chen, Jiang-Bin, Wang, Yang-Gan, Wang, Hai-Rong, Yu, Qin, He, Jing, Mao, Yi-Lin, Bin, Xiao-Fang, Deng, Yue, Tian, Yu-Dan, Han, Qing-Hua, Liu, Da-Jin, Duan, Li-Qin, Zhao, Ming-Jun, Zhang, Cui-Ying, Dai, Hai-Ying, Li, Ze-Hua, Xiao, Ying, Hu, You-Zhi, Huang, Xiao-Yu, Xing, Kun, Jiang, Xin, Liu, Chao-Feng, An, Jing, Li, Feng-Chun, Tao, Tao, Jiang, Jin-Fa, Yang, Ying, Dong, Yao-Rong, Zhang, Lei, Fu, Guang, Li, Ying, Huang, Shu-Wei, Dou, Li-Ping, Sun, Lan-Jun, Zhao, Ying-Qiang, Li, Jie, Xia, Yun, Liu, Jun, Liu, Fan, He, Wen-Jin, Li, Ying, Tan, Jian-Cong, Lin, Yang, Zhou, Ya-Bin, Yang, Jian-Fei, Ma, Guo-Qing, Chen, Hui-Jun, Liu, He-Ping, Liu, Zong-Wu, Liu, Jian-Xiong, Luo, Xiao-Jia, Bin, Xiao-Hong, Yu, Ya-Nan, Dang, Hai-Xia, Li, Bing, Teng, Fei, Qiao, Wang-Min, Zhu, Xiao-Long, Chen, Bing-Wei, Chen, Qi-Guang, Shen, Chun-Ti, Wang, Yong-Yan, Chen, Yun-Dai, Wang, Zhong
    Publicado 2021
    “…After performing the RNA sequencing in 62 selected patients, we developed a systemic modular approach to identify differentially expressed modules (DEMs) of DHI with the Z(summary) value less than 0 compared with the control group, calculated by weighted gene co-expression network analysis (WGCNA), and sketched out the basic framework on a modular map with 25 functional modules targeted by DHI. …”
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    Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial
  4. 366144
    “…METHODS: Observational study, based on a cross-sectional design, carried out with data deriving from the study “Nascer em Belo Horizonte: Inquérito sobre o Parto e Nascimento” (Born in Belo Horizonte: Survey on Childbirth and Birth). …”
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    Coexistence and prevalence of obstetric interventions: an analysis based on the grade of membership
  5. 366145
    “…Finally, an independent radiology professor rated the participants' performance (out of 100). All participants in two groups completed a Likert scale questionnaire regarding the educational utility and efficiency of 3D holograms. …”
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    A 3D Hologram With Mixed Reality Techniques to Improve Understanding of Pulmonary Lesions Caused by COVID-19: Randomized Controlled Trial
  6. 366146
    “…RESULTS: We found that PARP1 was altered in 1338 (2.9%) out of 45604 patients with diverse tumors, which was associated with markedly higher TMB levels in a variety of tumors (P < 0.01). …”
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    Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures
  7. 366147
    “…LIMITATIONS, REASONS FOR CAUTION: This was a historically controlled cohort study; introduction of bias cannot be ruled out. The follow-up rate was similar in the two groups and therefore could not explain the differences in pregnancy rate. …”
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    A concise infertility work-up results in fewer pregnancies
  8. 366148
    “…Recognizing the broader potential for such hitchhiking, we explored selection on co-infecting symbionts as a possible driver behind the dynamics of the remaining six species. Out of twelve examined instances of symbiont dynamics unfolding across 2-week periods or overwintering spans, we found eight in which the focal symbiont underwent parallel frequency shifts under single infection and one or more co-infection contexts. …”
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    Frequent Drivers, Occasional Passengers: Signals of Symbiont-Driven Seasonal Adaptation and Hitchhiking in the Pea Aphid, Acyrthosiphon pisum
  9. 366149
    “…The QI team member calculated the cardiovascular risk by utilizing the ASCVD plus application to determine inpatient cardiovascular risk. Out of 26 inpatients with SMI who underwent CVRA, nine (35%) scored moderate to high risk, and were referred to Cardiology for further intervention. …”
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    Cardiovascular risk assessment for patients with serious mental illnesses: An internal review
  10. 366150
    “…Patients were excluded from enrollment if they had not undergone a neurologic examination or cross-sectional brain imaging within the previous 4.5 h to rule out stroke and potential for hemorrhagic conversion. …”
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    Study of Alteplase for Respiratory Failure in SARS-CoV-2 COVID-19: A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized Controlled Trial
  11. 366151
    “…Statistical analysis was carried out by using Revman 5.4 software. RESULTS: Total 15 studies were included for systematic review, but only 5 randomized clinical trials (RCTs) (n = 13,622) were included for meta-analysis. …”
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    The safety, tolerability and mortality reduction efficacy of remdesivir; based on randomized clinical trials, observational and case studies reported safety outcomes: an updated systematic review and meta-analysis
  12. 366152
    “…Costs were estimated for delivering the intervention during the trial and from modeling a scale-up scenario, using a retrospective ingredients approach. Out of the 250 original trial participants, 176 (70.4%) adolescents participated in the 12-month follow-up assessment. …”
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    Effectiveness and costs associated with a lay counselor–delivered, brief problem-solving mental health intervention for adolescents in urban, low-income schools in India: 12-month outcomes of a randomized controlled trial
  13. 366153
    “…The programme was rolled out in Scotland during winter 2020–21, when SARS-CoV-2 infection rates were at their highest since the pandemic started, despite social distancing measures being in place. …”
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    COVID-19 hospital admissions and deaths after BNT162b2 and ChAdOx1 nCoV-19 vaccinations in 2·57 million people in Scotland (EAVE II): a prospective cohort study
  14. 366154
    “…METHODS: This is a prospective comparative cohort study carried out between May 2017 and May 2019. The study was approved by the IRB at Assiut University and done according to the Helsinki declaration. …”
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    Double versus triple arthrodesis for adult-acquired flatfoot deformity due to stage III posterior tibial tendon insufficiency: a prospective comparative study of two cohorts
  15. 366155
    “…Included studies reported a median of 3 out of nine psychometric properties. Most reported psychometric properties were construct validity (n = 32; 78% of studies), structural validity (n = 26; 63% of studies), and internal consistency (n = 25; 61% of studies). …”
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    A systematic review of tools designed for teacher proxy-report of children’s physical literacy or constituting elements
  16. 366156
    “…RESULTS: A total of 120 patients were assessed in the final analysis. Out of the 120 patients, 15 (12%) were KRAS G12C mutated. …”
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    Retrospective Comparative Analysis of KRAS G12C vs. Other KRAS Mutations in mCRC Patients Treated With First-Line Chemotherapy Doublet + Bevacizumab
  17. 366157
    “…Moreover, understanding the relationship between sample viral loads and epidemic dynamics provides additional insights into why viral loads from surveillance testing may appear higher for emerging viruses or variants and lower for out-breaks that are slowing, even absent changes in individual-level viral kinetics. …”
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    Estimating epidemiologic dynamics from cross-sectional viral load distributions
  18. 366158
    “…Path analysis was also used in the data analysis. RESULTS: Out of 10,845 PLWHA approached by the CBOs, 2740 completed the survey, and 170 had received at least one dose of the COVID-19 vaccine. …”
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    Willingness to Receive COVID-19 Vaccination Among People Living With HIV and AIDS in China: Nationwide Cross-sectional Online Survey
  19. 366159
    por Sun, Daokun, Richard, Melissa A., Musani, Solomon K., Sung, Yun Ju, Winkler, Thomas W., Schwander, Karen, Chai, Jin Fang, Guo, Xiuqing, Kilpeläinen, Tuomas O., Vojinovic, Dina, Aschard, Hugues, Bartz, Traci M., Bielak, Lawrence F., Brown, Michael R., Chitrala, Kumaraswamy, Hartwig, Fernando P., Horimoto, Andrea R.V.R., Liu, Yongmei, Manning, Alisa K., Noordam, Raymond, Smith, Albert V., Harris, Sarah E., Kühnel, Brigitte, Lyytikäinen, Leo-Pekka, Nolte, Ilja M., Rauramaa, Rainer, van der Most, Peter J., Wang, Rujia, Ware, Erin B., Weiss, Stefan, Wen, Wanqing, Yanek, Lisa R., Arking, Dan E., Arnett, Donna K., Barac, Ana, Boerwinkle, Eric, Broeckel, Ulrich, Chakravarti, Aravinda, Chen, Yii-Der Ida, Cupples, L. Adrienne, Davigulus, Martha L., de las Fuentes, Lisa, de Mutsert, Renée, de Vries, Paul S., Delaney, Joseph A.C., Diez Roux, Ana V., Dörr, Marcus, Faul, Jessica D., Fretts, Amanda M., Gallo, Linda C., Grabe, Hans Jörgen, Gu, C. Charles, Harris, Tamara B., Hartman, Catharina C.A., Heikkinen, Sami, Ikram, M. Arfan, Isasi, Carmen, Johnson, W. Craig, Jonas, Jost Bruno, Kaplan, Robert C., Komulainen, Pirjo, Krieger, Jose E., Levy, Daniel, Liu, Jianjun, Lohman, Kurt, Luik, Annemarie I., Martin, Lisa W., Meitinger, Thomas, Milaneschi, Yuri, O’Connell, Jeff R., Palmas, Walter R., Peters, Annette, Peyser, Patricia A., Pulkki-Råback, Laura, Raffel, Leslie J., Reiner, Alex P., Rice, Kenneth, Robinson, Jennifer G., Rosendaal, Frits R., Schmidt, Carsten Oliver, Schreiner, Pamela J., Schwettmann, Lars, Shikany, James M., Shu, Xiao-ou, Sidney, Stephen, Sims, Mario, Smith, Jennifer A., Sotoodehnia, Nona, Strauch, Konstantin, Tai, E. Shyong, Taylor, Kent D., Uitterlinden, André G., van Duijn, Cornelia M., Waldenberger, Melanie, Wee, Hwee-Lin, Wei, Wen-Bin, Wilson, Gregory, Xuan, Deng, Yao, Jie, Zeng, Donglin, Zhao, Wei, Zhu, Xiaofeng, Zonderman, Alan B., Becker, Diane M., Deary, Ian J., Gieger, Christian, Lakka, Timo A., Lehtimäki, Terho, North, Kari E., Oldehinkel, Albertine J., Penninx, Brenda W.J.H., Snieder, Harold, Wang, Ya-Xing, Weir, David R., Zheng, Wei, Evans, Michele K., Gauderman, W. James, Gudnason, Vilmundur, Horta, Bernardo L., Liu, Ching-Ti, Mook-Kanamori, Dennis O., Morrison, Alanna C., Pereira, Alexandre C., Psaty, Bruce M., Amin, Najaf, Fox, Ervin R., Kooperberg, Charles, Sim, Xueling, Bierut, Laura, Rotter, Jerome I., Kardia, Sharon L.R., Franceschini, Nora, Rao, Dabeeru C., Fornage, Myriam
    Publicado 2020
    “…To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP, taking into account the interaction effects of genetic variants with three psychosocial factors: depressive symptoms, anxiety symptoms, and social support. …”
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    Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits
  20. 366160
    “…BACKGROUND: Concerns have been raised about the ability of patients with plasma cell disorders (PCD) to mount adequate immune responses to vaccination, particularly considering the initial extension to vaccination intervals in the United Kingdom to up to 12 weeks in December 2020, the start of the vaccination roll-out. Protecting this vulnerable patient group with anti-SARS-CoV-2 vaccination is critical. …”
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    OAB-047: Plasma cell disorder patients are left vulnerable after one dose of the BNT162b2 mRNA or the ChAdOx-nCOV-19 COVID-19 vaccines
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