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367261por Ballke, Simone, Heid, Irina, Mogler, Carolin, Braren, Rickmer, Schwaiger, Markus, Weichert, Wilko, Steiger, Katja“…Additionally, longitudinal analyses of preclinical models often use a variety of imaging methods and much more attention should be drawn to enable for proper co-registration of in vivo imaging methods with the ex vivo morphological read-outs. Here we present the development of the Comparative Experimental Pathology (CEP) unit embedded in the Institute of Pathology of the Technical University of Munich during the Collaborative Research Center 824 (CRC824) funding period together with selected approaches of histomorphological techniques for correlation of in vivo imaging to morphomolecular pathology.…”
Publicado 2021
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367262por Yu, He, van de Loosdrecht, Marieke S., Mannino, Marcello A., Talamo, Sahra, Rohrlach, Adam B., Childebayeva, Ainash, Villalba-Mouco, Vanessa, Aron, Franziska, Brandt, Guido, Burri, Marta, Freund, Cäcilia, Radzeviciute, Rita, Stahl, Raphaela, Wissgott, Antje, Fewlass, Helen, Tagliacozzo, Antonio, Piperno, Marcello, Tusa, Sebastiano, Collina, Carmine, Schimmenti, Vittoria, Di Salvo, Rosaria, Prüfer, Kay, Posth, Cosimo, Hublin, Jean-Jacques, Gronenborn, Detlef, Binder, Didier, Jeong, Choongwon, Haak, Wolfgang, Krause, Johannes“…The genetic discontinuities during the Mesolithic and Early Neolithic match the changes in material culture and diet. Three outlying individuals dated to ∼8,000 yBP; however, suggest that hunter-gatherers interacted with incoming farmers at Grotta dell’Uzzo, resulting in a mixed economy and diet for a brief interlude at the Mesolithic-Neolithic transition.…”
Publicado 2022
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367263por Alsinet, Clara, Primo, Maria Nascimento, Lorenzi, Valentina, Bello, Erica, Kelava, Iva, Jones, Carla P., Vilarrasa-Blasi, Roser, Sancho-Serra, Carmen, Knights, Andrew J., Park, Jong-Eun, Wyspianska, Beata S., Trynka, Gosia, Tough, David F., Bassett, Andrew, Gaffney, Daniel J., Alvarez-Errico, Damiana, Vento-Tormo, Roser“…Using CRISPR/Cas9 knock-outs, we validate the effects of key transcription factors in macrophage and DC ontogeny. …”
Publicado 2022
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367264“…Second, we successfully employed CRISPRi for modifying cell morphology by repressing ftsZ, an essential gene required for cell division, in combination with targeted knock‐outs to generate significantly enlarged filamentous or spherical cells respectively. …”
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367265“…We demonstrate the utility of our proposed approach through microbial data analyses, including by identifying outlying gene histories in strains of Prevotella, and by contrasting Streptococcus phylogenies estimated using different gene sets. …”
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367266“…A major problem in the interpretation of BeLPT test results is outlying data values among the replicate well counts (approximately 7%). …”
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367267por Young, G.“…Within 5 hours, the organisms were recovered from all outlying areas of the pouches, and in the following hours the entire structures showed vasodilation, edema, petechiae, and accumulation of leukocytes in the venules. …”
Publicado 1954
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367268por Sadot, Avital, Sarbu, Septimia, Kesseli, Juha, Amir-Kroll, Hila, Zhang, Wei, Nykter, Matti, Shmulevich, Ilya“…We show that this analysis successfully captures the essential information in the dynamics of the system, which results from a variety of events including proliferation, differentiation, or perturbations such as gene knock-outs. We demonstrate that this approach can be used for the analysis of executable models, regardless of the modeling framework, and for making experimentally quantifiable predictions.…”
Publicado 2013
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367269“…We tested this hypothesis using constitutive knock-outs and single-cell molecular replacement of AMPA receptor subunits in mouse hippocampus. …”
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367270por Moebius, Nadine, Üzüm, Zerrin, Dijksterhuis, Jan, Lackner, Gerald, Hertweck, Christian“…Through targeted gene knock-outs, sporulation assays and microscopic investigations we found that chitinase is essential for bacteria to enter hyphae. …”
Publicado 2014
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367271“…The increasing quality and coverage of metabolomics technologies have fostered the development of computational approaches for integrating metabolic read-outs with large-scale models to predict the physiological state of a system. …”
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367272“…We hope this overview will guide TB researchers in the design, choice of read-outs, and interpretation of future studies in the search for predictive biomarkers and novel therapies.…”
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367273“…This is due to the small number of replicates for each gene and the existence of outlying data. Comparison of the performance of these models is made using different statistical criteria and the ROC curve. …”
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367274“…However, usual relevance and redundancy criteria have the disadvantages of being too sensitive to the presence of outlying measurements and/or being inefficient. We propose a novel approach called Minimum Regularized Redundancy Maximum Robust Relevance (MRRMRR), suitable for noisy high-dimensional data observed in two groups. …”
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367275por Miranda, Pedro Jeferson, Delgobo, Murilo, Marino, Giovani Favero, Paludo, Kátia Sabrina, da Silva Baptista, Murilo, de Souza Pinto, Sandro Ely“…We compared the changes of a “healthy” network caused by “knock-outs” (KOs) in two approaches: an analytical approach by the Perron Frobenius theory; and a computational approach, which we describe within this work in order to find numerical results for the model. …”
Publicado 2015
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367276“…This paper reviews the various technologies for maximum conversion of cellulose and hemicelluloses fraction to ethanol, and it point outs several key properties that should be targeted for low cost and maximum yield.…”
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367277“…As one of data mining techniques, outlier detection aims to discover outlying observations that deviate substantially from the reminder of the data. …”
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367278por Cheng, Ben, Cunningham, Brad, Boeras, Debrah I., Mafaune, Patron, Simbi, Raiva, Peeling, Rosanna W.“…Furthermore, by linking the data to existing supply chain management software, stock-outs can be minimised. As countries are looking forward to achieving the 90-90-90 targets for HIV, such innovative technologies can automate disease surveillance, improve the quality of testing and strengthen the efficiency of health systems.…”
Publicado 2016
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367279“…Some applications such as generation of double knock-outs, large deletions and paired-nickase cleavage require simultaneous expression of two gRNAs. …”
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367280“…Here, we used excision of chromosomal regions as circular “loop outs” to convert sister chromatid intertwines into catenated circles. …”
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