“…Indeed, aux1 lax1 lax2 lax3 quadruple knock‐outs are mostly viable and fertile, and strong phenotypes are only observed at low penetrance. …”
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“…The personalised nature of such systems, combined with physiologically relevant read-outs, provides new opportunities for person-specific assessment of drug efficacy and safety, as well as personalised strategies for disease prevention and treatment; together, this is known as ‘precision medicine’. …”
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“…The intra-substance tear showed some vascularity at the medial and lateral ends, and one of the glenoid pull-outs demonstrated micro-calcification and osteoid formation. …”
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“…CONCLUSION: We apply one-class SVM and isolation forest anomaly detection algorithms to a set of hidden connections to rank connections by identifying outlying (interesting) ones and show that the approach increases the F(1) measure by a factor of 10 while greatly reducing the quantity of hidden knowledge to manually verify. …”
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“…Eastern Colorado GRECC Connect integrates Associated Health Trainees (Audiology, Psychology, Social Work, Pharmacy) and Geriatric Medicine Fellows into interdisciplinary tele-geriatric and tele-palliative care consultations provided to outlying community-based outpatient clinics. The formal telehealth training includes: (1) an initial didactic orientation to introduce skills, common challenges, and important tips when working with older patients and caregivers via telehealth; (2) direct observation and modeling by preceptors, followed by a structured opportunity to debrief what the trainee observed and address questions; and (3) opportunities to provide Geriatric telehealth services, supported by the interprofessional team and feedback and reflection. …”
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“…The Front Loading sputum microscopy can be implemented in DOTS clinic on the day of first visit of patients to health care center to increase compliance of patients with diagnostic procedure and decrease drop-outs.…”
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“…They are detected by their outlying values of morphometric features. Then an attempt is made to separate them using the seeded watershed segmentation. …”
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“…From the Identification and prevention of Dietary- and lifestyle induced health EFfects In Children and infantS (IDEFICS) study, and based on the data availability in each period due to drop outs, 8807 children aged 2 to 9.9 years from eight European countries at baseline (T0: 2007–2008); 5085 children after two years (T1); and 1991 after four years (T3), were included in these analyses. …”
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“…Finally, we highlight potential future research avenues such as integrating GWAS results with single-cell sequencing read-outs, designing functionally informed polygenic risk scores (PRS), and validating disease associated genes using genetic engineering. …”
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“…Furthermore, they highlight the effect of a handful of outlying hubs, rather than of the connectivity distribution law as a whole, on network dynamics.…”
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“…The primary outcome will be growth-related anthropometric indicators, and acceptability, measured through drop-outs that occur during treatment for any reason. …”
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“…These results demonstrate that CRISPR/Cas9 editing efficiency can be significantly increased in a polyploid cereal species with a simple change in growth conditions to facilitate increased mutations for the creation of homozygous or null knock-outs.…”
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“…Case Description: A 19-year-old male collegiate baseball pitcher presented to an outpatient physical therapy clinic via direct access for left antecubital pain, which began 6 weeks prior to the evaluation while pitching during try-outs. Following physical examination, distal biceps tendinopathy was the likely clinical diagnosis. …”
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“…The subjects of this research were in-school youths and school drop-outs who joined the three waves of “Social-Up Youth Entrepreneurship Programme” including social entrepreneurship training (T1), internship (T2), and a pre-incubation project funded by a Charities Trust in Hong Kong. …”
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“…In contrast, Case 6 was extraordinarily outlying, but the reason is unclear. CONCLUSIONS: In‐S is an excellent predictor for assessing indium load in the lungs in ITO or/and indium trioxide‐exposed workers. …”
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“…The authors propose the use of several simple methods easily employed in the critical care setting to make uncertainty explicit by changing the language used for expressing differential diagnosis, incorporating probabilities into daily sign-outs, and by implementing inductive reasoning when teaching critical thinking to offer learners a strategy for working through unknown problems; these approaches may normalize uncertainty, improve comfort with it, and reduce the impact of cognitive bias in decision-making. …”
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“…However, completers in longitudinal studies may be somewhat more well-organized and academically oriented than drop-outs.…”
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“…In psychotherapy, higher movement synchrony between therapist and patient has been associated with higher levels of empathy, therapeutic alliance, better therapy outcome, and fewer drop-outs. The current study investigated movement synchrony during the psychotherapeutic treatment of female adolescents with borderline personality disorder. …”
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“…Sampling points were selected to characterize the profile of the organosol within the peatland, the soil profile between the peatland and the agricultural land, and the soil profile of the outlying agricultural land, which is used as permanent grassland. …”
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“…METHODOLOGY/PRINCIPAL FINDINGS: We used the previously established CRISPR/Cas9 system to mediate ablation of Ku80- and Ku70-encoding genes in L. mexicana. Complete knock-outs of both genes were confirmed by Southern blotting, whole-genome Illumina sequencing, and RT-qPCR. …”
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