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  1. 367581
    “…The MCA system provides multi-parameter analysis capabilities incorporating field potential recording, impedance spectroscopy, and optical read-outs on individual clusters giving a comprehensive insight into induced cellular alterations within a complex cardiac culture over days or even weeks.…”
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    A Novel 3D Label-Free Monitoring System of hES-Derived Cardiomyocyte Clusters: A Step Forward to In Vitro Cardiotoxicity Testing
  2. 367582
    “…On average, patients in the extreme outlying population (0.7% of purchasers), presumed to be doctor shoppers, obtained 32 opioid prescriptions from 10 different prescribers. …”
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    Estimating the Prevalence of Opioid Diversion by “Doctor Shoppers” in the United States
  3. 367583
    “…Predictions from in silico knock-outs and steady state model analysis were validated using literature searches and in vitro based experiments. …”
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    Dynamics of DNA Damage Induced Pathways to Cancer
  4. 367584
    “…However, analysis of the roles of PcG proteins in maintaining differentiation programs during vertebrate embryogenesis has been hampered due to the early embryonic lethality of several PcG knock-outs in the mouse. Here, we show that zebrafish Ring1b/Rnf2, the single E3 ubiquitin ligase in the Polycomb Repressive Complex 1, critically regulates the developmental program of craniofacial cell lineages. …”
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    The Polycomb Group Protein Ring1b/Rnf2 Is Specifically Required for Craniofacial Development
  5. 367585
    “…In this study, by using two independent Wnt7a/Frizzled9-specific read-outs, we identify G(α16) as a novel downstream effector of Wnt7a/Frizzled9 signaling. …”
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    Heterotrimeric G-Protein, G(α16), Is a Critical Downstream Effector of Non-Canonical Wnt Signaling and a Potent Inhibitor of Transformed Cell Growth in Non Small Cell Lung Cancer
  6. 367586
    “…After excluding extreme outlying measurements, median systolic and diastolic blood pressure measurements were calculated for each individual and were compared for subjects who did and did not report taking one of a list of 37 different supplements listed on the DHQ more than once per week over the previous 12 months. …”
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    The use of dietary supplements and their association with blood pressure in a large Midwestern cohort
  7. 367587
    “…There were no apparent differences in the reported difficulty of the response tasks, but the triads had the highest number of drop-outs. DISCUSSION: Multidimensional scaling proved to be a feasible method to scale health-state similarity data. …”
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    Quantification of Health by Scaling Similarity Judgments
  8. 367588
    “…In sharp contrast, down-regulation of Nck2 hardly impacts these activation read-outs. Thus, in contrast to Nck2, Nck1 is a positive regulator for TCR-induced stimulation of the Erk pathway. …”
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    Non-overlapping functions of Nck1 and Nck2 adaptor proteins in T cell activation
  9. 367589
    “…The very considerable geographic variation in the disparity in rates of PPH admission between Indigenous and non-Indigenous people indicates that there is potential to reduce unwarranted variation by characterising outlying areas which contribute the most to this disparity.…”
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    The Contribution of Geography to Disparities in Preventable Hospitalisations between Indigenous and Non-Indigenous Australians
  10. 367590
    “…The associated resource use was also modelled, and ambulance call-outs and hospitalisations were considered. The patient’s quality of life was estimated by clinicians, who completed a five-level EuroQol five dimensions questionnaire from the perspective of a child or adolescent suffering a seizure. …”
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    A comparison of the cost-effectiveness of treatment of prolonged acute convulsive epileptic seizures in children across Europe
  11. 367591
    “…Consequently, substantial efforts have been directed toward such outlying loci in order to identify traits subject to local adaptation. …”
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    Fin whale MDH-1 and MPI allozyme variation is not reflected in the corresponding DNA sequences
  12. 367592
    “…Key barriers included the reluctance to engage in HIV services while healthy, rigid clinic policies, disrespectful treatment from service providers, stock-outs of supplies, stigma and discrimination, alternate healing systems, distance to health facilities and poverty. …”
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    Multi-Level Factors Affecting Entry into and Engagement in the HIV Continuum of Care in Iringa, Tanzania
  13. 367593
    “…In addition, simultaneous deletion of both genes revealed a further increase of cell proliferation compared to single knock-outs and WT control mice, while apoptosis or self-renewal ability were not affected in any of the genotypes. …”
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    Simultaneous Deletion of p21(Cip1/Waf1) and Caspase-3 Accelerates Proliferation and Partially Rescues the Differentiation Defects of Caspase-3 Deficient Hematopoietic Stem Cells
  14. 367594
    por Coelho, Raquel B., Costa., Filipa A.
    Publicado 2014
    “…Of the 271 patients’ beneficiaries of pharmaceutical counseling, 86.8% had their minor health problems solved after one week (ranging from 77.5% to 88.2% according to a sensibility analysis for drop-outs). CONCLUSIONS: This work is important as it demonstrates the beneficial impact of pharmaceutical counseling, a very relevant area for the pharmacist and where literature is particularly scarce.…”
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    Impact of pharmaceutical counseling in minor health problems in rural Portugal
  15. 367595
    “…The outcome was expressed as sensitivity, specificity and predictive values and compared with a risk assessment scheme used in Public Dental Service. RESULTS: The drop-outs displayed more risk factors and a significantly higher caries burden at baseline compared with those that remained in the project (p < 0.05). …”
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    Caries risk assessment in young adults: a 3 year validation of the Cariogram model
  16. 367596
    “…We address the role of environmental variation versus competition in coexistence between two rodent species: Rhabdomys bechuanae (bechuanae) and Rhabdomys dilectus dilectus (dilectus) comparing their habitat preference and home range (HR) size in areas with similar climates, where their distributions abut (allopatry) or overlap (sympatry). Using Outlying Mean Index analyses, we test whether habitat characteristics of the species deviate significantly from a random sample of available habitats. …”
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    Space Use Variation in Co-Occurring Sister Species: Response to Environmental Variation or Competition?
  17. 367597
    “…Moreover, in silico gene knock-outs identified unique control points for each cell line model, e.g., phosphoglycerate dehydrogenase for the Molt-4 model. …”
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    Prediction of intracellular metabolic states from extracellular metabolomic data
  18. 367598
    por Najavits, Lisa M.
    Publicado 2015
    “…The two PTSD therapies most studied in relation to retention and dropout are Prolonged Exposure and Cognitive Processing Therapy, which have been the subject of massive, formal, multi-year dissemination roll-outs. Both of these evidence-based treatments are defined as gold-standard therapies for PTSD and showed positive outcomes and reasonable retention of patients in randomized controlled trials (RCTs). …”
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    The problem of dropout from “gold standard” PTSD therapies
  19. 367599
    “…This relationship remained evident even when calculations excluded an outlying patient from the nonomental cohort (22.5 versus 111 days, respectively; P < 0.05). …”
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    Flap Reconstruction for Esophageal Perforation Complicating Anterior Cervical Spinal Fusion: An 18-year Experience
  20. 367600
    “…Serum biomarkers in Duchenne muscular dystrophy (DMD) may provide deeper insights into disease pathogenesis, suggest new therapeutic approaches, serve as acute read-outs of drug effects, and be useful as surrogate outcome measures to predict later clinical benefit. …”
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    Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy
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