por
Ren, Yilin,
Meng, Dechuan,
Wu, Linping,
Chen, Jinchun,
Wu, Qiong,
Chen, Guo‐Qiang
Publicado 2016
“…Polylactide (PLA) is a bio‐based plastic commonly synthesized by chemical catalytic reaction using lactic acid (LA) as a substrate. Here,
novel LA‐containing terpolyesters, namely, P[LA‐co‐3‐hydroxybutyrate (3HB)‐co‐3‐hydroxypropionate (3HP)], short as PLBP, were successfully synthesized for the first time by a recombinant Escherichia coli harbouring polyhydroxyalkanoate (PHA) synthase from Pseudomonas stutzeri (PhaC1(Ps)) with 4‐point mutations at E130D, S325T, S477G and Q481K, and 3‐hydroxypropionyl‐CoA (3HP‐CoA) synthesis pathway from glycerol, 3‐hydroxybutyryl‐CoA (3HB‐CoA) as well as lactyl‐CoA (LA‐CoA) pathways from glucose. …”
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