“…OBJECTIVE: Herein, we report a preliminary investigation of (68)Ga-Galmydar potential to monitor Dox-induced cardiomyopathy in vivo, ex vivo, and in cellulo employing both nuclear- and optical imaging. METHODS AND RESULTS: To assess (68)Ga-Galmydar ability for monitoring DOX-induced cardiomyopathy, microPET imaging was performed 5 d post treatment of rats either with a single dose of DOX (15 mg/kg) or vehicle as a control (saline) and images were co-registered for anatomical reference using CT. …”
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“…PURPOSE: Using current optical imaging techniques and gamma imaging modalities, perioperative sentinel lymph node (SLN) identification in colon cancer can be difficult when the SLN is located near the primary tumour or beneath a thick layer of (fat) tissue. …”
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“…We recently implemented a novel and cost-effective approach based on Molecular Inversion Probe Sequencing (MIPS) to identify novel variants and candidate genes in sporadic trios and familial cases of combined pituitary deficiency (CPHD) in the absence or presence of any midline defects or optic nerve hypoplasia, and isolated growth hormone deficiency (IGHD). …”
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“…Brain MRI showed a large sellar mass 34 x 25 x 25 mm eroding the clivus and extending into the sphenoid sinus, with bilateral cavernous sinus invasion but no optic chiasm compression. Endocrine evaluation showed central hypogonadism and hypothyroidism: TSH 2.62 uIU/mL (0.45-4.5); free T4 0.8 ng/dL (0.82-1.77); total testosterone 229.3 ng/dL (264-916); LH 4.8 mIU/mL (1.7-8.6).…”
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“…Subsequent imaging revealed a 24 x 26 mm sellar mass extending into the right cavernous sinus and encroaching upon the optic chiasm. Endocrine evaluation demonstrated prolactin (PRL) of 68,000 mIU/L and accompanying hypogonadism (testosterone 1.3 nmol/L, FSH 1.8 IU/L, LH 1.4 IU/L), hypoadrenalism (peak cortisol 272 nmol/L after 250 mcg synacthen) and hypothyroidism (TSH 2.9 mIU/L, T4 8 pmol/L). …”
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“…Brain MRI showed a markedly enlarged pituitary gland with mass effect upon the optic chiasm and hemorrhage consistent with pituitary apoplexy. …”
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“…For those patients that harbor a macroadenoma, surgery is indicated in case of visual function disturbances, risk for future optic nerve or chiasm compression, and tumor progression during follow-up. …”
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“…His prolactin was 4916 ng/mL (nl 4-15.2 ng/mL) and MRI showed a large sellar and suprasellar mass, 2.5 x 3.5 x 3.1 cm, extending into the interpeduncular cistern and cavernous sinus while compressing the optic chiasm and right cerebral peduncle. He was started on Carbergoline 0.5 mg, 5 days a week for 2 weeks, then 4 days a week. …”
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“…Cranial MRI with contrast defined the mass to be 2.6 cm lobulated sellar-suprasellar mass, compressing the optic chiasm, consistent of hemorrhagic pituitary macroadenoma. …”
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“…MRI with and without contrast revealed a 1.5 x 1.8 x 1.8cm sellar lesion with characteristics most consistent with Rathke’s cleft cyst (RCC) with mass effect on the infundibulum and optic chiasm. The patient was started on cabergoline 0.25mg twice a week and Neurosurgery was consulted. …”
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“…There was compression on the undersurface of the optic chiasm. The infundibulum was markedly compressed and displaced superiorly. …”
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“…A Brain Magnetic Resonance (MRI) showed a spontaneous hyperintense image of 5x4,5 mm on the T1 weighted within a diffuse enlargement pituitary gland in contact with the optic chiasm. A pituitary apoplexy was suspected, so immediate treatment with intravenous hydrocortisone was started. …”
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“…Ten patients had septo-optic dysplasia (SOD) and 2 had multiple pituitary deficiencies with pituitary stalk interruption syndrome. …”
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“…Best-corrected visual acuity (BCVA) and central retinal thickness (CRT) were measured using Early Treatment Diabetic Retinopathy Study (ETDRS) charts and spectral-domain optical coherence tomography (OCT). The measurements were taken at the baseline and then at 16, 32, and 48 weeks. …”
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“…By enzyme-linked immunosorbent assay (ELISA), there were small increases in serum anti-FH levels at 3 weeks postvaccination (geometric mean optical density at 405 nm [OD(405)], 0.54 versus 0.51 preimmunization, P ≤ 0.003 for each schedule tested). …”
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“…OBJECTIVES: To summarise and compare the accuracy of physical examination, computed tomography (CT), sonography of the optic nerve sheath diameter (ONSD), and transcranial Doppler pulsatility index (TCD-PI) for the diagnosis of elevated intracranial pressure (ICP) in critically ill patients. …”
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“…Fundus photography and optical coherence tomography/angiography (OCT/OCTA) were performed with a Topcon Triton. …”
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“…BACKGROUND: Although visual acuity and optical coherence tomography (OCT) are most widely used as outcomes in treatment of neovascular age-related Macular Degeneration (nAMD), patient reported outcome measures are increasingly recognized. …”
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“…Whereas unilateral intraocular retinoblastoma is cured by enucleation of the eye, infiltration of the optic nerve indicates potential diffuse scattering and tumor spread leading to a major therapeutic challenge. …”
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“…Abbreviations: ALP: autophagy-lysosome pathway; ARE: antioxidant response element; Atg8a: autophagy-related 8a; ATPsynβ: ATP synthase, β subunit; C-L: caspase-like proteasomal activity; cncC: cap-n-collar isoform-C; CT-L: chymotrypsin-like proteasomal activity; Drp1: dynamin related protein 1; ER: endoplasmic reticulum; foxo: forkhead box, sub-group O; GLU: glucose; GFP: green fluorescent protein; GLY: glycogen; Hsf: heat shock factor; Hsp: Heat shock protein; Keap1: kelch-like ECH-associated protein 1; Marf: mitochondrial assembly regulatory factor; NFE2L2/Nrf2: nuclear factor, erythroid 2 like 2; Opa1: optic atrophy 1; PN: proteostasis network; RNAi: RNA interference; ROS: reactive oxygen species; ref(2)P: refractory to sigma P; SQSTM1: sequestosome 1; SdhA: succinate dehydrogenase, subunit A; T-L: trypsin-like proteasomal activity; TREH: trehalose; UAS: upstream activation sequence; Ub: ubiquitin; UPR: unfolded protein response; UPP: ubiquitin-proteasome pathway.…”
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