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102por Chisari, Clara G., Bianco, Assunta, Brescia Morra, Vincenzo, Calabrese, Massimiliano, Capone, Fioravante, Cavalla, Paola, Chiavazza, Carlotta, Comi, Cristoforo, Danni, Maura, Filippi, Massimo, Iaffaldano, Pietro, Lanzillo, Roberta, Lo Fermo, Salvatore, Lucisano, Alessandra, Lugaresi, Alessandra, Lus, Giacomo, Marfia, Gerolama Alessandra, Marinelli, Fabiana, Mirabella, Massimiliano, Moiola, Lucia, Perin, Chiara, Realmuto, Sabrina, Toscano, Simona, Trojano, Maria, Vecchio, Domizia, Patti, Francesco“…A total of 149 (25.3%) received ocrelizumab according to the ORATORIO criteria (ORATORIO group) and 440 (74.7%) outside the ORATORIO criteria (non-ORATORIO group). …”
Publicado 2023
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103por Wolinsky, Jerry S, Engmann, Natalie J, Pei, Jinglan, Pradhan, Ashish, Markowitz, Clyde, Fox, Edward J“…BACKGROUND: Ocrelizumab, an anti-CD20 humanized monoclonal antibody, reduced disease progression in pivotal trials of patients with relapsing (OPERA I, OPERA II) and primary progressive (ORATORIO) multiple sclerosis (MS). These effects may be particularly important among patients with increased disability. …”
Publicado 2020
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104por Brossard, Sébastien de, d. 1730Tabla de Contenidos: “…Salve Rex Christe -- Psallite superi -- Qui non diligit te -- O Domine quia refugium -- Templa nunc fument -- Oratorio seu Dialogus poenitentis animae cum Deo -- Festis laeta sonent.…”
Publicado 1998
CD Audiom -
105Tabla de Contenidos: “…The Creatión-Oratorio for solo Voices, Chourus and orchestra.…”
CD Audiom -
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113Association of Higher Ocrelizumab Exposure With Reduced Disability Progression in Multiple Sclerosispor Hauser, Stephen L., Bar-Or, Amit, Weber, Martin S., Kletzl, Heidemarie, Günther, Andreas, Manfrini, Marianna, Model, Fabian, Mercier, Francois, Petry, Claire, Wing, Qing, Koendgen, Harold, Smith, Terence, Kappos, Ludwig“…METHODS: Patients in OPERA I/II and ORATORIO were grouped in exposure quartiles based on their observed individual serum ocrelizumab level over the treatment period. …”
Publicado 2023
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114“…Large trials conducted for ocrelizumab showed malignancies in a total of 4 cases with RRMS in OPERA 1 trial conducted over 2 years from 2011 to 2013 (breast cancer, renal cell carcinoma, and melanomas) and in 11 cases with PPMS seen in ORATORIO trial conducted in 2017. There are currently no other published case reports of breast cancer in setting of ocrelizumab use for MS outside of large trials on literature review.…”
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115por Daniels, K., van der Nat, P. B., Frequin, S. T. F. M., van der Wees, P. J., Biesma, D. H., Hoogervorst, E. L. J., van de Garde, E. M. W.“…BACKGROUND: Recently, ocrelizumab (Ocrevus®) was approved for the treatment of primary progressive multiple sclerosis (PPMS) based on data from the ORATORIO clinical trial. Real-world data about the clinical effectiveness of ocrelizumab has yet to be gathered. …”
Publicado 2020
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116por Abert, Hermann, 1871-1927Tabla de Contenidos: “…Childhood -- Travels of the child prodigy -- Works from the grand tour -- Studies in Salzburg -- The first operas in Vienna -- Gesellschaftsmusik and church music of 1769 -- The first Italian journey -- The second and third Italian journeys -- Opera seria -- Early operas and the oratorio la betulia liberata -- Church and instrumental works, 1769-1773 -- On the road to 'La finta giardiniera' -- Opera buffa -- La finta giardiniera -- Mozart in Salzburg, 1775 -- Munich and Augsburg -- Mannheim -- Arrival in Paris : tragédie lyrique -- 'Opéra comique' -- The music dramas of Gluck -- Mozart in Paris -- Homecoming -- Service at the Salzburg court -- Sacred and instrumental works, 1779-1781-- König Thamos and Zaide -- Idomeneo -- First steps in Vienna -- The German singspiel -- Die Entführung aus dem Serail -- Engagement and marriage -- Mozart's personality -- Relations with Constanze, friends and colleagues, 1782-1786 -- Mozart and Freemasonry -- In the service of the aristocracy and society -- Plans for new operas -- Mozart and artistic creativity -- Perfpimd changes in style: the influence of J.S. …”
Publicado 2007
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117por Montalban, Xavier, Matthews, Paul M., Simpson, Alex, Petrie, John L., Sammon, Cormac, Ramagopalan, Sreeram, Disanto, Giulio, Kuhle, Jens“…Real‐world effectiveness data for ocrelizumab were consistently favorable, with reductions in relapse rate and disease progression rates similar to those reported in the OPERA I/OPERA II and ORATORIO clinical trials, including in studies with more diverse patient populations not well represented in the pivotal trials. …”
Publicado 2023
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118por Arnold, Douglas L, Sprenger, Till, Bar-Or, Amit, Wolinsky, Jerry S, Kappos, Ludwig, Kolind, Shannon, Bonati, Ulrike, Magon, Stefano, van Beek, Johan, Koendgen, Harold, Bortolami, Oscar, Bernasconi, Corrado, Gaetano, Laura, Traboulsee, Anthony“…OBJECTIVE: To assess the efficacy of ocrelizumab compared with interferon beta-1a (IFNβ1a)/placebo on thalamic volume loss and the effect of switching to ocrelizumab on volume change in the Phase III trials in relapsing MS (RMS, OPERA I/II; NCT01247324/NCT01412333) and in primary progressive MS (PPMS, ORATORIO; NCT01194570). METHODS: Thalamic volume change was computed using paired Jacobian integration and analyzed using an adjusted mixed-effects repeated measurement model. …”
Publicado 2022
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119por Frau, Jessica, Coghe, Giancarlo, Lorefice, Lorena, Fenu, Giuseppe, Cocco, Eleonora“…In particular, OPERA I and II trials, which were performed in patients with RRMS, showed a reduction in the annualized relapse rate, the risk of disability progression, and the number of new/enlarging T2 lesions and enhancing lesions measured using brain magnetic resonance. The ORATORIO trial, performed in PP subjects, showed that OCR can reduce disability progression, improve performance on the timed 25-foot walk, and decrease the total volume of T2 lesions and the mean number of new or enlarging T2 lesions. …”
Publicado 2018
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120“…The phase III trial (ORATORIO) in patients with PPMS met its primary efficacy endpoint: the percentage of patients with 12-week confirmed disability progression was significantly lower in the active treatment group (32.9%) than in patients receiving placebo (39.3%). …”
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