“…Even the smallest disturbances in the orchestration of circadian gene expression patterns among different tissues can result in functional asynchrony, at the organism level, and may to contribute to a wide range of physiologic disorders. …”
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“…Orchestration of signaling, photoreceptor structural integrity, and maintenance needed for mammalian vision remain enigmatic. …”
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“…Here we show that the coordinated orchestration of both baseline and experience-dependent epigenetic regulation seen in the young adult hippocampus is lost in association with cognitive aging. …”
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“…We have thus discovered a surprising role for alternatively activated macrophages in the orchestration of an important mammalian stress response, the response to cold.…”
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“…However, the molecular mechanisms underlying the orchestration of these regulatory factors remain unclear. …”
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“…These results strongly suggest that the avSG is the locus for non-self RNA sensing and the orchestration of multiple proteins is critical in the triggering of antiviral responses.…”
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“…Embryo development requires precise orchestration of cell proliferation and differentiation in both time and space. …”
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“…Together these data suggest that the clustering and dispersion processes involve a complex orchestration of phosphorylation-dependent, microtubule-dependent and independent, and microfilament dependent steps.…”
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“…Although most studies focus on utilizing MSCs to direct clinical efficacy, it is the ability to orchestrate host response in surrounding tissue that is especially unique and versatile. …”
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“…The orchestration of histone modifiers is required to establish the epigenomic status that regulates gene expression during development. …”
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“…To overcome these challenges, this paper proposes a platform to manage the integration and behavior-aware orchestration of heterogeneous devices as services, stored and accessed via the cloud, with the following contributions: (i) we describe a lightweight model to specify the behavior of devices, to determine the order of the sequence of exchanged messages during the composition of devices; (ii) we define a common architecture using a service-oriented standard environment, to integrate heterogeneous devices by means of their interfaces, via a gateway, and to orchestrate them according to their behavior; (iii) we design a framework based on cloud computing technology, connecting the gateway in charge of acquiring the data from the devices with a cloud platform, to remotely access and monitor the data at run-time and react to emergency situations; and (iv) we implement and generate a novel cloud-based IoT platform of behavior-aware devices as services for ambient intelligence systems, validating the whole approach in real scenarios related to a specific ambient assisted living application.…”
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“…We have coined the term metabostemness to refer to the metabolic parameters causally controlling or functionally substituting the epitranscriptional orchestration of the genetic reprograming that redirects normal and tumor cells toward less-differentiated cancer stem cell (CSC) cellular states. …”
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“…Control of cytokine production by immune cells is pivotal for counteracting infections via orchestration of local and systemic inflammation. Although their contribution has long been underexposed, it has recently become clear that human Fc gamma receptors (FcγRs), which are receptors for the Fc region of immunoglobulin G (IgG) antibodies, play a critical role in this process by controlling tissue- and pathogen-specific cytokine production. …”
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“…Thus, a prototypic component of humoral innate immunity, PTX3, plays a nonredundant role in the orchestration of tissue repair and remodeling. Tissue acidification resulting from metabolic adaptation during tissue repair sets PTX3 in a tissue remodeling and repair mode, suggesting that matrix and microbial recognition are common, ancestral features of the humoral arm of innate immunity.…”
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“…The development of a properly functioning PFC is directed by transcription factors, guidance cues and other regulatory molecules and requires the intricate and temporal orchestration of a number of developmental processes. …”
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“…A small cut will normally heal in days through tight orchestration of cell migration and appropriate levels of inflammation, innervation and angiogenesis. …”
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“…Here, we investigated the orchestration by testosterone (T) of birdsong and its neural substrate, the song control system. …”
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“…The axolotl (Ambystoma mexicanum, Ambystomatidae) has a courtship display that suggests a key role for chemical communication in the orchestration of its sexual behavior, but no sex pheromones have yet been characterized from this species. …”
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“…A greater understanding of the complex orchestration of the hepatic adaptive immune regulators during homeostasis and immune competence are much needed to identify relevant targets for clinical intervention to treat immunological disorders in the liver.…”
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“…Altogether, our results provide a comprehensive view on the diversity and evolution of replication systems in the DNA virome and uncover fundamental principles underlying the orchestration of viral DNA replication.…”
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