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  1. 3321
    “…The energy homeostasis of the organism is orchestrated by a complex interplay of energy substrate shuttling, breakdown, storage, and distribution. …”
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    Hepatic Energy Metabolism under the Local Control of the Thyroid Hormone System
  2. 3322
    por de Magalhães, João Pedro
    Publicado 2023
    “…Here, I propose that we age not because of inevitable damage to the hardware but rather because of intrinsic design flaws in the software, defined as the DNA code that orchestrates how a single cell develops into an adult organism. …”
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    Ageing as a software design flaw
  3. 3323
    “…The circadian system orchestrates a ~24-h rhythm in bodily functions in synchrony with the day-night cycle, and disturbed circadian regulation plays an important role in many age-related health consequences. …”
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    Circadian disturbances and frailty risk in older adults: a prospective cohort study
  4. 3324
    “…The mechanisms underlying several sickness symptoms have been shown to be orchestrated by the brain, specifically, the hypothalamus. …”
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    Viral Gastroenteritis: Sickness Symptoms and Behavioral Responses
  5. 3325
    “…The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays a critical role in orchestrating immune and inflammatory responses, and it is essential for a wide range of cellular processes, including differentiation, cell growth, and apoptosis. …”
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    The Use of JAK/STAT Inhibitors in Chronic Inflammatory Disorders
  6. 3326
    “…To provide competent T-cells tolerant to self-antigens, medullary thymic epithelial cells (mTECs) orchestrate negative selection by ectopically expressing a wide range of genes, including various tissue-restricted antigens (TRAs). …”
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    Revisiting Aire and tissue-restricted antigens at single-cell resolution
  7. 3327
    “…How does the scaffold orchestrate this step? We have determined the portal vertex structure of the bacteriophage HK97 procapsid, where the scaffold is a domain of the major capsid protein. …”
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    A symmetry mismatch unraveled: How phage HK97 scaffold flexibly accommodates a 12-fold pore at a 5-fold viral capsid vertex
  8. 3328
    “…Here, we focus on the mechanisms through which LOXL2 orchestrates multiple oncogenic functions in HCC development. …”
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    Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting
  9. 3329
    “…Circadian clocks temporally orchestrate biological processes critical for cellular/organ function. …”
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    Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology
  10. 3330
    “…Antioxidant supplementation orchestrates protection against oxidative stress and damage—L-arginine and antioxidants such as vitamin C increase NO production and bioavailability. …”
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    Nitric Oxide as a Determinant of Human Longevity and Health Span
  11. 3331
    “…Because normal ovulation is modulated by immune cells and cytokines in the ovarian microenvironment, the endocrine and metabolic abnormalities associated with PCOS orchestrate the accompanying adverse effects on ovulation and implantation. …”
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    Immune Dysfunction in Polycystic Ovary Syndrome
  12. 3332
    “…The circadian system orchestrates ~24-h rhythms in bodily functions in synchrony with the day-night cycle, and disturbed circadian regulation plays an important role in many age-related health consequences. …”
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    Circadian disturbances and frailty risk in older adults
  13. 3333
    “…Elucidation of the mechanisms underlying the chemomechanical energy conversion by the dynein arms and their orchestrated movement in cilia/flagella is of great importance, but the nucleotide-dependent three-dimensional (3D) movement of dynein has not yet been observed. …”
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    Three-dimensional structures of the flagellar dynein–microtubule complex by cryoelectron microscopy
  14. 3334
    “…Instead, they relied on cells of the innate immune system, specifically on cross talk between CD8α(+) dendritic cells and natural killer cells, resulting in suppression of neutrophil recruitment to the joint, orchestrated through interleukin-12 and interferon-γ. …”
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    Inflammatory arthritis can be reined in by CpG-induced DC–NK cell cross talk
  15. 3335
    “…Centrosomes play a pivotal role in orchestrating the formation of the bipolar spindle during mitosis. …”
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    Centrobin: a novel daughter centriole–associated protein that is required for centriole duplication
  16. 3336
    “…These cytokines induce the secretion of chemokines and antimicrobial proteins, thereby orchestrating the mucosal barrier against gastrointestinal pathogens. …”
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    Th17 Cytokines and the Gut Mucosal Barrier
  17. 3337
    “…Bacterial infection relies on the micro-organism's ability to orchestrate the host's cell signalling such that the immune response is not activated. …”
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    How ubiquitination and autophagy participate in the regulation of the cell response to bacterial infection
  18. 3338
    por Satish, Latha, Kathju, Sandeep
    Publicado 2010
    “…Adult (postnatal) skin wound healing is a complex and well-orchestrated process spurred by attendant inflammation that leads to wound closure with scar formation. …”
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    Cellular and Molecular Characteristics of Scarless versus Fibrotic Wound Healing
  19. 3339
    “…However, at present, there are no clear guidelines for an orchestrated optimal treatment plan.…”
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    Thalassaemia Intermedia: an Update
  20. 3340
    “…CD4(+) T-cells, especially T-helper type 2 cells, play a critical role in orchestrating the disease process through the release of the cytokines IL-4, IL-5, and IL-13. …”
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    Allergen-specific subcutaneous immunotherapy in allergic asthma: immunologic mechanisms and improvement
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