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3361por Kara, Ervin E., Comerford, Iain, Fenix, Kevin A., Bastow, Cameron R., Gregor, Carly E., McKenzie, Duncan R., McColl, Shaun R.“…In this review, recent insights into the molecular mechanisms that govern differentiation and function of effector helper T cell subsets will be discussed in the context of microbial infections, with a focus on how these different helper T cell subsets orchestrate immune responses tailored to combat the nature of the pathogenic threat encountered.…”
Publicado 2014
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3362“…Collectively, these cells orchestrate the defense against a wide range of pathogens and environmental challenges, but also perform a number of homeostatic functions. …”
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3363“…This process is likely mediated through the formation of a tightly orchestrated complex of HCV entry factors at the plasma membrane. …”
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3364“…We present a model that may explain how the capsid protein has a fundamental role in the early part of the viral lifecycle by utilising cyclophilin A (CypA), cleavage and polyadenylation specificity factor-6 (CPSF6), Nup358 and TNPO3 to orchestrate a coordinated process of DNA synthesis, capsid uncoating and integration targeting that evades innate responses and promotes integration into preferred areas of chromatin.…”
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3365“…The FA signaling network orchestrates the DNA damage recognition and repair in interphase as well as proper execution of mitosis. …”
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3366“…SSC proliferation is a well regulated mechanism and is mainly orchestrated by the Sertoli cells. In the future, SSCs may offer clinically relevant options for preservation and re-establishment of the reproductive potential in patients suffering from spermatogonial stem cell loss, i.e. after gonadotoxic treatments for cancer or haematological diseases. …”
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3367por Nenseth, Hatice Z., Dezitter, Xavier, Tesikova, Martina, Mueller, Florian, Klokk, Tove I., Hager, Gordon L., Saatcioglu, Fahri“…However, it is unknown whether transcription is similarly orchestrated by different TFs bound at the same RE. Here we have compared the recovery half time (t(1/2)), binding site occupancy and the resulting temporal changes in transcription upon binding of two closely related steroid receptors, the androgen and glucocorticoid receptors (AR and GR), to their common hormone REs (HREs). …”
Publicado 2014
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3368“…The endothelium is the orchestral conductor of blood vessel function. Pathological blood vessel formation (a process termed pathological angiogenesis) or the inability of endothelial cells (ECs) to perform their physiological function (a condition known as EC dysfunction) are defining features of various diseases. …”
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3369“…Compared to the overwhelming amount of literature describing how epithelial-to-mesenchymal transition (EMT)-inducing transcription factors orchestrate cellular plasticity in embryogenesis and epithelial cells, the functions of these factors in non-epithelial contexts, such as melanoma, are less clear. …”
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3370“…DCs sense the presence of the staphylococcal components using pattern recognition receptors (PRRs) and then orchestrate immune systems to resolve infections. This review summarizes the possible roles of DCs, in particular their Toll-like receptors (TLRs) involved in S. aureus infection and strategies by which the pathogen affects activation and function of DCs.…”
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3371por Sato, Ken-ichi“…Here, it will be briefly reviewed how oocyte cytoplasmic components are orchestrated to undergo hormone-induced oocyte maturation and sperm-induced activation of development. …”
Publicado 2014
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3372“…In this review, we examine how Srcmediated phosphorylation regulates caveolae-mediated transport by orchestrating the localization and activity of essential proteins of the endocytic machinery to regulate caveolae formation and fission.…”
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3373“…Our lab has established a novel imaging approach in live mice using the skin as a model system to investigate these fundamental processes in both physiological and pathological settings such as cancer, with the goal of understanding how tissues successfully orchestrate tissue regeneration throughout the lifetime of an organism.…”
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3374“…The 3′UTR governs gene expression via orchestrated interactions between mRNA structural components (cis-elements) and specific trans-acting factors (RNA-binding proteins and non-coding RNAs). …”
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3375“…Here, we review recent findings in the gene regulatory networks that orchestrate leaf meristem activities in a model plant Arabidopsis thaliana. …”
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3376“…Enveloped viruses employ a class of proteins known as fusogens to orchestrate the merger of their surrounding envelope and a target cell membrane. …”
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3377por Cohen, Pascale A., Donini, Caterina F., Nguyen, Nhan T., Lincet, Hubert, Vendrell, Julie A.“…Newly discovered molecular functions of ZNF217 indicate that it orchestrates complex intracellular circuits as a new key regulator of tumorigenesis. …”
Publicado 2015
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3378por Bonomo, Adriana, Monteiro, Ana Carolina, Gonçalves-Silva, Triciana, Cordeiro-Spinetti, Eric, Galvani, Rômulo Gonçalves, Balduino, Alex“…Our main hypothesis is that the partnership between T cells and cells of the BM microenvironment orchestrates numerous processes regulating immunity, hematopoiesis, and bone remodeling.…”
Publicado 2016
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3379“…The recruitment of inflammatory cells is a dynamic and superbly orchestrated process. Sequential infiltration of the injured myocardium with neutrophils, monocytes and their descendant macrophages, dendritic cells, and lymphocytes contributes to the initiation and resolution of inflammation, infarct healing, angiogenesis, and ventricular remodeling. …”
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3380“…Epigenetic parameters orchestrating transgenerational effects, as well as heritable disorders, and the often-overlooked areas of livestock immunity and stress, are also discussed. …”
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