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  1. 3461
    “…The circadian clock controls several aspects of mammalian physiology and orchestrates the daily oscillations of biological processes and behavior. …”
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    The Circadian Clock and Viral Infections
  2. 3462
    “…Cancer immunotherapies have generated some miracles in the clinic by orchestrating our immune system to combat cancer cells. …”
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    Polymeric Micelles in Cancer Immunotherapy
  3. 3463
    “…Here, we will review the advances that have been made in the last five years to understand the molecular mechanisms orchestrating the presentation of novel endogenous and exogenous lipid-based antigens by the CD1 glycoproteins and their recognition by specific populations of CD1-reactive T cells.…”
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    Novel Molecular Insights into Human Lipid-Mediated T Cell Immunity
  4. 3464
    “…No strategy exists, however, to orchestrate the execution of transformations if the network has an arbitrary topology. …”
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    Finding a Universal Execution Strategy for Model Transformation Networks
  5. 3465
    “…Autophagy is an evolutionarily conserved and a highly orchestrated catabolic recycling process that guarantees cellular homeostasis. …”
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    A protective role for autophagy in vitiligo
  6. 3466
    “…Functional synapses orchestrate the assembly of ion channels, receptors, enzymes, and scaffold proteins in both pre- and post-synapse. …”
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    Liprin-α-Mediated Assemblies and Their Roles in Synapse Formation
  7. 3467
    “…Many of the proteins involved in this highly orchestrated process are post-translationally modified with lipids as a means of regulating signal transduction, membrane remodeling, phagosome maturation and other immunomodulatory functions of phagocytes. …”
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    Examining the Underappreciated Role of S-Acylated Proteins as Critical Regulators of Phagocytosis and Phagosome Maturation in Macrophages
  8. 3468
    “…Tenascin C (TnC) is a glycoprotein highly expressed in the extracellular matrix (ECM) during development and in the adult central nervous system (CNS) in regions of active neurogenesis, where neuron development is a tightly regulated process orchestrated by extracellular matrix components. In addition, newborn cells also communicate with glial cells, astrocytes and microglia, indicating the importance of signal integration in adult neurogenesis. …”
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    The Extracellular Matrix Glycoprotein Tenascin C and Adult Neurogenesis
  9. 3469
    “…How these integrative responses are orchestrated is not completely understood. Here, we provide insight into these mechanisms by studying pupariation, a multi-step innate behavior of Drosophila larvae that is critical for survival during metamorphosis. …”
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    The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction
  10. 3470
    “…This review will briefly revisit how the oocyte orchestrate the follicular cells, and how molecules transit to the oocyte from the innermost (cumulus) and outermost (antrum and granulosa cells) layers surrounding the follicle-enclosed oocyte. …”
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    Contributions from the ovarian follicular environment to oocyte function
  11. 3471
    por Kylat, Ranjit I
    Publicado 2021
    “…P. aeruginosa can perceive unfavorable environmental changes and orchestrate adaptations by developing plasmid-mediated and adaptive resistance to antibiotics. …”
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    Pseudomonas aeruginosa necrotizing bronchopneumonia
  12. 3472
    “…Thanks to the advances in molecular biology, it has been proposed that some aspects of the RV and pulmonary vascular remodeling processes are orchestrated by a subversion of developmental regulatory mechanisms with an upregulation of a suite of genes responsible for the embryo’s early growth and normally repressed in adults. …”
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    Fetal Gene Reactivation in Pulmonary Arterial Hypertension: GOOD, BAD, or BOTH?
  13. 3473
    “…Therefore, OTX2 protein plays an important role in ZGA and TE expression in mESCs to orchestrate the transcriptional network.…”
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    Transcription factor OTX2 silences the expression of cleavage embryo genes and transposable elements
  14. 3474
    por Sun, Ying, Liu, Yang, Ma, Xiaoli, Hu, Hao
    Publicado 2021
    “…Cell cycle regulation is orchestrated by a complex network of interactions between proteins, enzymes, cytokines, and cell cycle signaling pathways, and is vital for cell proliferation, growth, and repair. …”
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    The Influence of Cell Cycle Regulation on Chemotherapy
  15. 3475
    “…One of these pathways, the inflammasome pathway, activates a family of cysteine proteases called inflammatory caspases. They orchestrate an immune response by cleaving specific cellular substrates. …”
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    Great balls of fire: activation and signalling of inflammatory caspases
  16. 3476
    por Nogueiras, Ruben
    Publicado 2021
    “…Bodyweight is regulated by the ability of the CNS, and especially the hypothalamus, to orchestrate the function of peripheral organs that play a key role in metabolism. …”
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    MECHANISMS IN ENDOCRINOLOGY: The gut–brain axis: regulating energy balance independent of food intake
  17. 3477
    “…In this limiting landscape, cumulative research attention has centred on deepening the roles of major phytohormones, mostly auxins, together with brassinosteroids, jasmonates, and abscisic acid, despite the signaling networks orchestrating the crosstalk among them are so far only poorly understood. …”
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    Beyond the Usual Suspects: Physiological Roles of the Arabidopsis Amidase Signature (AS) Superfamily Members in Plant Growth Processes and Stress Responses
  18. 3478
    por de Soárez, Patrícia Coelho
    Publicado 2021
    “…The survival of this policy will depend not only on science but on the art of orchestrating the interests of various agents so that HTA becomes a health policy for strengthening and sustainability of SUS.…”
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    Health Technology Assessment: informed by science or in the service of politics?
  19. 3479
    por Meyer-Schwesinger, Catherine
    Publicado 2021
    “…Due to its center position in an intricate network of trafficking events, the lysosome has emerged as a central signaling node for sensing and orchestrating the cells metabolism and immune response, for inter-organelle and inter-cellular signaling and in membrane repair. …”
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    Lysosome function in glomerular health and disease
  20. 3480
    “…We provide a comprehensive review of the complex networks orchestrated by several of the most potent immunosuppressive metabolites, highlighting the impact of adenosine, kynurenines, prostaglandin E2, and norepinephrine and epinephrine, while discussing completed and ongoing clinical efforts to curtail their impact. …”
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    Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward
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