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  1. 3601
    por Desai, Bimal N., Leitinger, Norbert
    Publicado 2014
    “…In the immune system, purinergic signals regulate the migration and activation of immune cells and they may also orchestrate the resolution of inflammation (1, 2). The intracellular signal transduction initiated by purinergic receptors is strongly coupled to Ca(2+)-signaling, and co-ordination of these pathways plays a critical role in innate immunity. …”
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    Purinergic and Calcium Signaling in Macrophage Function and Plasticity
  2. 3602
    por Ndlovu, H, Brombacher, F
    Publicado 2014
    “…Research conducted in mouse models of schistosomiasis has provided great insights and understanding of how host protective immunity is orchestrated and key cellular populations involved in this process. …”
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    Role of IL-4Rα during acute schistosomiasis in mice
  3. 3603
    “…The patterning and morphogenesis of body appendages – such as limbs and fins – is orchestrated by the activities of several developmental pathways. …”
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    Canonical Wnt signalling regulates epithelial patterning by modulating levels of laminins in zebrafish appendages
  4. 3604
    por Talamas, Jessica A., Capelson, Maya
    Publicado 2015
    “…Details of how this concert is orchestrated and how it directs cell differentiation and disease are coming to light at a rapid pace. …”
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    Nuclear envelope and genome interactions in cell fate
  5. 3605
    por Yap, Chan Choo, Winckler, Bettina
    Publicado 2015
    “…Proper cortical development depends on the orchestrated actions of a multitude of guidance receptors and adhesion molecules and their downstream signaling. …”
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    Adapting for endocytosis: roles for endocytic sorting adaptors in directing neural development
  6. 3606
    “…Early B cell development is orchestrated by the combined activities of the transcriptional regulators E2A, EBF1, Foxo1 and Ikaros. …”
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    Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth
  7. 3607
    “…In addition to the orchestrated remodeling of the chromatin landscape, we find that the binding of several transcription factors is strongly associated with specific loss of DNA methylation in one germ layer and in many cases a reciprocal gain in the other layers. …”
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    Transcription factor binding dynamics during human ESC differentiation
  8. 3608
    por Cavaillon, Jean-Marc
    Publicado 2015
    “…Tumor necrosis factor (TNF) is a fascinating anti-tumoral cytokine, which plays a key role in orchestrating the fight of innate immunity against infection. …”
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    The fiendish behavior of TNF can be counteracted by microRNA
  9. 3609
    “…Immunological memory is one of the defining features of the adaptive immune system. As key orchestrators and mediators of immunity, CD4 T cells are central to the vast majority of adaptive immune responses. …”
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    Development and Function of Protective and Pathologic Memory CD4 T Cells
  10. 3610
    por Kurosaka, Hiroshi
    Publicado 2015
    “…Craniofacial development consists of a highly complex sequence of the orchestrated growth and fusion of facial processes. It is also known that craniofacial abnormalities can be detected in 1/3 of all patients with congenital diseases. …”
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    The Roles of Hedgehog Signaling in Upper Lip Formation
  11. 3611
    “…The exquisitely tight regulation of S1P availability may explain how a single lipid can simultaneously orchestrate many immune cell movements.…”
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    A map of sphingosine 1-phosphate distribution in the spleen
  12. 3612
    por Zhang, Huaye
    Publicado 2016
    “…Although many questions remain unanswered in our understanding of how polarity proteins regulate spine development and plasticity, current and future research will undoubtedly shed more light on how this conserved group of proteins orchestrates different pathways to shape the neuronal circuitry.…”
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    Polarity Determinants in Dendritic Spine Development and Plasticity
  13. 3613
    “…The signals that orchestrate T-cell activation are coordinated within a highly organized interface with the antigen-presenting cell (APC), known as the immune synapse (IS). …”
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    Vesicular Trafficking to the Immune Synapse: How to Assemble Receptor-Tailored Pathways from a Basic Building Set
  14. 3614
    “…There are numerous T cell subsets, each with differing functions, which together have the ability to orchestrate the immune response to S. aureus and hence to tip the balance between protection and pathology. …”
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    The T Cell Response to Staphylococcus aureus
  15. 3615
    “…Here, we focus on the emerging and sometimes contradictory roles of mTOR in orchestrating lymphoid cell-mediated host immune responses to pathogens. …”
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    mTOR Regulation of Lymphoid Cells in Immunity to Pathogens
  16. 3616
    por Morrison, Shaun F.
    Publicado 2016
    “…Central neural circuits orchestrate the behavioral and autonomic repertoire that maintains body temperature during environmental temperature challenges and alters body temperature during the inflammatory response and behavioral states and in response to declining energy homeostasis. …”
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    Central control of body temperature
  17. 3617
    por Meitinger, Franz, Palani, Saravanan
    Publicado 2016
    “…This review summarizes the recent progresses in our understanding of how budding yeast cells orchestrate the multitude of molecular mechanisms that control AMR driven cytokinesis in a spatio-temporal manner to achieve an error free cell division.…”
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    Actomyosin ring driven cytokinesis in budding yeast
  18. 3618
    “…Selective target recognition, mediated by specific adapter proteins, enables autophagy to orchestrate highly specialized functions in innate and adaptive immunity. …”
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    Autophagy in Plasma Cell Ontogeny and Malignancy
  19. 3619
    “…We thus conclude that carefully orchestrated developmental processes are under strong constraint in early brain development, and perturbations caused by mutation have adverse outcomes subject to strong purifying selection. …”
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    Network Analysis of Genome-Wide Selective Constraint Reveals a Gene Network Active in Early Fetal Brain Intolerant of Mutation
  20. 3620
    “…These phenotypic properties include activation of genes regulating glycolysis, glucose transport, acidosis regulators, angiogenesis, all of which are orchestrated through the activation of the transcription factor, HIF1A, which is an independent marker of poor prognosis. …”
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    Targeting hypoxic response for cancer therapy
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