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  1. 3641
    “…The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays critical roles in orchestrating of immune system, especially cytokine receptors and they can modulate the polarization of T helper cells. …”
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    The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
  2. 3642
    “…Our results demonstrate how an evolutionarily conserved protein involved in the regulation of microtubule dynamics orchestrates NLRP3 inflammasome activation by controlling its transport to optimal activation sites, and identify a targetable function for MARK4 in the control of innate immunity.…”
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    MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism
  3. 3643
    “…Porphyromonas gingivalis is a Gram-negative anaerobic rod that has been proposed as an orchestrator of complement-dependent dysbiotic inflammation. …”
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    Porphyromonas gingivalis disturbs host–commensal homeostasis by changing complement function
  4. 3644
    por Nakajima, Yu-ichiro, Kuranaga, Erina
    Publicado 2017
    “…Caspases are at the core of executing apoptosis by orchestrating cellular destruction with proteolytic cascades. …”
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    Caspase-dependent non-apoptotic processes in development
  5. 3645
    por Bortnik, Svetlana, Gorski, Sharon M.
    Publicado 2017
    “…Accumulating knowledge of the particular mechanisms and players involved in different steps of autophagy regulation led to the ongoing discovery of small molecule inhibitors designed to disrupt this highly orchestrated process. However, the development of validated autophagy-related biomarkers, essential for rational selection of patients entering clinical trials involving autophagy inhibitors, is lagging behind. …”
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    Clinical Applications of Autophagy Proteins in Cancer: From Potential Targets to Biomarkers
  6. 3646
    “…Elongation of iPSC colonies impacts also on their intrinsic molecular patterning, which seems to be orchestrated from the rim of the colonies. BMP4-induced differentiation is enhanced in elongated colonies, and the submicron grooves impact on the spatial modulation of YAP activity upon induction with this morphogen. …”
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    Surface Topography Guides Morphology and Spatial Patterning of Induced Pluripotent Stem Cell Colonies
  7. 3647
    “…This review primarily focuses on the current understanding of how transcriptional, post-transcriptional, post-translational, and epigenetic processes along with genetic variation orchestrate stress responses in plants. We also discuss the current and future development of computational tools to identify biologically meaningful factors from high dimensional, genome-scale data and construct the signaling networks consisting of these components.…”
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    Multilevel Regulation of Abiotic Stress Responses in Plants
  8. 3648
    por Ganesan, Kumar, Xu, Baojun
    Publicado 2017
    “…Health-promoting information was gathered and orchestrated at a suitable place in the review.…”
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    Polyphenol-Rich Lentils and Their Health Promoting Effects
  9. 3649
    “…The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of important cell cycle regulators. …”
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    Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C)
  10. 3650
    “…In this review, we discuss the classical signaling pathways orchestrated by the Hippo signaling pathway, and describe how Mst1/2 direct T cell function by mechanisms not seeming to involve the classical Hippo pathway. …”
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    The Role of Mst1 in Lymphocyte Homeostasis and Function
  11. 3651
    “…In the nucleus, protein regulation via the UPS orchestrates gene expression, genome maintenance, and signal transduction. …”
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    Roles of E3 Ubiquitin-Ligases in Nuclear Protein Homeostasis during Plant Stress Responses
  12. 3652
    por Chen, Hui, Liu, Hudan, Qing, Guoliang
    Publicado 2018
    “…Myc has a central role in almost every aspect of the oncogenic process, orchestrating proliferation, apoptosis, differentiation, and metabolism. …”
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    Targeting oncogenic Myc as a strategy for cancer treatment
  13. 3653
    “…We hypothesize that, in combination with antiretroviral drugs, a strategy to orchestrate CD4 T cell trafficking could contribute to a functional cure for HIV-1 infection.…”
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    Increased T cell trafficking as adjunct therapy for HIV-1
  14. 3654
    “…Furthermore, we distilled genome-wide expression profiles orchestrated by the NMDAR-GKAP signaling axis, identifying transcriptome signatures in tumors with low/inhibited NMDAR activity that significantly associate with favorable patient prognosis in several cancer types.…”
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    GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth
  15. 3655
    “…Notably, the gene regulatory networks orchestrated by enhancer methylation across different cancer types are seen to converge on a common architecture. …”
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    MICMIC: identification of DNA methylation of distal regulatory regions with causal effects on tumorigenesis
  16. 3656
    “…Both channels are expressed in the SMDD neurons, which are required and sufficient for head bending, and mediate coordinated head steering by sensing mechanical stretches due to the contraction of head muscle and orchestrating dorsal head muscle contractions. Moreover, the SMDD neurons play dual roles to sense muscle stretch as well as to control muscle contractions. …”
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    A sensory-motor neuron type mediates proprioceptive coordination of steering in C. elegans via two TRPC channels
  17. 3657
    “…Apoptosis must not be considered only as a fail on germ cell physiology or a secondary effect of certain pathologies and exogenous hazardous agents. Apoptosis orchestrates correct function and development of the male germ cell from the early embryonic stages of gonadal differentiation to the fertilization. …”
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    Apoptosis Is a Demanding Selective Tool During the Development of Fetal Male Germ Cells
  18. 3658
    “…In this respect, efferocytosis, i.e., the process of dead cell clearance, is orchestrated through cell exposure of a set of “find me,” “eat me,” and “tolerate me” signals facilitating the engulfment of dying cells through phagocytosis by macrophages and dendritic cells. …”
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    The Role of Efferocytosis in Autoimmune Diseases
  19. 3659
    “…AIM: RACK1 is a multifunctional scaffolding protein that is expressed in many cellular compartments, orchestrating a number of signaling processes. RACK1 acts as a signaling hub to localize active enzymes to discrete locations; therefore tight control of RACK1 is vital to cellular homeostasis. …”
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    RAB40C regulates RACK1 stability via the ubiquitin–proteasome system
  20. 3660
    “…The concept of transitions between cell cycle stages as decisional processes integrating multiple inputs instead of cascading from orchestrated steps can affect the way we think of the cell cycle in general.…”
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    Concurrent processes set E. coli cell division
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