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  1. 1801
    “…Recent studies suggest that orchestration of the MSU-induced inflammatory response is dependent on the proinflammatory cytokine IL-1β, underlined by promising results in early IL-1 inhibitor trials in gout patients. …”
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    The role of the NLRP3 inflammasome in gout
  2. 1802
    por Oikawa, Tsukasa, Matsuo, Koichi
    Publicado 2012
    “…Fusion of biological membranes involves the intricate orchestration of various proteins and lipids. Recent literature suggests the importance of membrane curvature formation in lipid bilayer fusion. …”
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    Possible role of IRTKS in Tks5-driven osteoclast fusion
  3. 1803
    “…However, it remains unclear whether such assembly factor-like proteins play an indispensable role in orchestration of proteasome subunits in archaea. We revealed that PbaB forms a homotetramer and exerts a dual function as an ATP-independent proteasome activator and a molecular chaperone through its tentacle-like C-terminal segments. …”
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    An Archaeal Homolog of Proteasome Assembly Factor Functions as a Proteasome Activator
  4. 1804
    por Gibbs, Bernhard F
    Publicado 2008
    “…This review highlights these exciting advances that go far in unraveling our understanding of basophil function in the orchestration of allergic inflammation.…”
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    Basophils as Key Regulators of Allergic Inflammation and Th2-type Immunity
  5. 1805
    “…Plant mitochondria are proposed to act as signaling organelles in the orchestration of defense responses to biotic stress and acclimation responses to abiotic stress. …”
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    The signaling role of a mitochondrial superoxide burst during stress
  6. 1806
    por Ahmed, Khawaja Ashfaque, Xiang, Jim
    Publicado 2011
    “…In a multicellular system, cellular communication is a must for orchestration and coordination of cellular events. Advent of the latest analytical and imaging tools has allowed us to enhance our understanding of the intercellular communication. …”
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    Mechanisms of cellular communication through intercellular protein transfer
  7. 1807
    “…The careful orchestration of cellular events such as DNA replication, repair, and segregation is essential for equal distribution of the duplicated genome into two daughter cells. …”
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    Dual Control of Yen1 Nuclease Activity and Cellular Localization by Cdk and Cdc14 Prevents Genome Instability
  8. 1808
    “…The orchestration of gene-expression programs is essential for cellular homeostasis. …”
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    Histone-acetylation: a link between Alzheimer's disease and post-traumatic stress disorder?
  9. 1809
    por Michlmayr, Daniela, Lim, Jean K.
    Publicado 2014
    “…Under neuroinflammatory conditions, as in the case of viral encephalitides, the infiltration of leukocytes is often required for efficient viral clearance and recovery. The orchestration of leukocyte migration into the inflamed CNS is largely coordinated by a large family of chemotactic cytokines and their receptors. …”
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    Chemokine receptors as important regulators of pathogenesis during arboviral encephalitis
  10. 1810
    “…As a result, the interconnection and orchestration of devices is one of the central issues of the IoT paradigm. …”
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    Architecture of a Service-Enabled Sensing Platform for the Environment
  11. 1811
    “…In contrast to the well mapped molecular orchestration of circadian timekeeping in terrestrial organisms, the mechanisms that direct tidal and lunar rhythms in marine species are entirely unknown. …”
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    Metabolic molecular markers of the tidal clock in the marine crustacean Eurydice pulchra
  12. 1812
    “…In recent years, evidence has accumulated that they are also important in the orchestration of adaptive immunity. Neutrophils rapidly migrate in high numbers to sites of inflammation (e.g., infection, tissue damage, and cancer) and are subsequently able to migrate to draining lymph nodes (LNs). …”
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    How Neutrophils Shape Adaptive Immune Responses
  13. 1813
    “…Therefore, chronic stress may impair PFC functions required for the adaptive orchestration of behavioral responses. In the present review, we integrate evidence obtained from cognitive neuroscience with neurophysiological research with animal models, to put forward a hypothesis that addresses stress-induced behavioral dysfunctions observed in stress-related neuropsychiatric disorders. …”
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    Impaired Functional Connectivity in the Prefrontal Cortex: A Mechanism for Chronic Stress-Induced Neuropsychiatric Disorders
  14. 1814
    por Xiao, Jun, Jin, Run, Wagner, Doris
    Publicado 2017
    “…Recent discoveries have advanced our understanding of the orchestration of plant developmental switches by transcriptional master regulators, chromatin state changes, and hormone response pathways. …”
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    Developmental transitions: integrating environmental cues with hormonal signaling in the chromatin landscape in plants
  15. 1815
    “…Microglia are brain immune cells that actively maintain health through their crucial physiological roles exerted across the lifespan, including phagocytosis of cellular debris and orchestration of neuroinflammation. The past decade has witnessed an explosive growth of microglial research. …”
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    Roles of Microglial Phagocytosis and Inflammatory Mediators in the Pathophysiology of Sleep Disorders
  16. 1816
    “…Emerging data demonstrate that epigenetic mechanisms and transcriptional factors are becoming increasingly appreciated in the orchestration of macrophage polarization in response to local environmental signals. …”
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    Promising landscape for regulating macrophage polarization: epigenetic viewpoint
  17. 1817
    por Symmank, Judit, Zimmer, Geraldine
    Publicado 2017
    “…The limited regenerative capacity of neuronal cells requires tight orchestration of cell death and survival regulation in the context of longevity, age-associated diseases as well as during the development of the nervous system. …”
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    Regulation of neuronal survival by DNA methyltransferases
  18. 1818
    por Li, Melanie, Sirko, Swetlana
    Publicado 2018
    “…Given the fundamental role of the brain in the orchestration of endocrine processes through interactions among neurohormones, it is thus not surprising that the structural and/or functional alterations following traumatic brain injury (TBI) can lead to endocrine changes affecting the whole organism. …”
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    Traumatic Brain Injury: At the Crossroads of Neuropathology and Common Metabolic Endocrinopathies
  19. 1819
    “…RAB proteins, small monomeric GTPases belonging to the RAS superfamily, spatially and temporally orchestrate specific vesicular trafficking steps. In this review we summarise the known roles of RAB GTPases involved in the maintenance of neuronal vesicular trafficking in the central nervous system. …”
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    Critical importance of RAB proteins for synaptic function
  20. 1820
    “…The mammalian neocortex is composed of a diverse population of neuronal and glial cells that are crucial for cognition and consciousness. Orchestration of molecular events that lead to the production of distinct cell lineages is now a major research focus. …”
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    Sonic Hedgehog Signaling Rises to the Surface: Emerging Roles in Neocortical Development
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