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31081por AlMahadin, Ghayth, Lotfi, Ahmad, Zysk, Eva, Siena, Francesco Luke, Carthy, Marie Mc, Breedon, Philip“…Patients’ and healthcare professionals’ involvement in wearable devices design process has a pivotal role in terms of ultimate user acceptance. …”
Publicado 2020
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31082por Huang, Feng, Sun, Fei, Wan, Wei-Guo, Wu, Li-Jun, Dong, Ling-Li, Zhang, Xiao, Kim, Tae-Hwan, Sengupta, Raj, Šenolt, Ladislav, Wang, Yi, Qiu, Hao-Min, Porter, Brian, Haemmerle, Sibylle“…BACKGROUND: Secukinumab demonstrated sustained efficacy in patients with ankylosing spondylitis (AS) through 5 years in pivotal Phase III studies. Here, we present efficacy and safety results (52-week) of secukinumab in patients with AS from the MEASURE 5 study. …”
Publicado 2020
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31083por Tandon, Ishita, Johns, Shelby, Woessner, Alan, Perez, Jessica, Cross, Delaney, Ozkizilcik, Asya, Muldoon, Timothy J., Vallurupalli, Srikanth, Padala, Muralidhar, Quinn, Kyle P., Balachandran, Kartik“…Early detection of disease progression is thus pivotal in the development of prevention and mitigation strategies. …”
Publicado 2020
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31084por Fouogue, Jovanny Tsuala, Noubom, Michel, Kenfack, Bruno, Dongmo, Norbert Tanke, Tabeu, Maxime, Megozeu, Linda, Alima, Jean Marie, Fogang, Yannick Fogoum, Nyam, Landry Charles Rim A, Fouelifack, Florent Ymele, Fouedjio, Jeanne Hortence, Manebou, Pamela Leonie Fouogue Nzogning, Bibou Ze, Clotaire Damien, Kouam, Brice Foubi, Fomete, Lauriane Nomene, Tebeu, Pierre Marie, Kemfang, Jean Dupont Ngowa, Foumane, Pascal, Sando, Zacharie, Orock, George Enownchong Enow“…Whatever the strategy, the role of health staff is pivotal. Objective: Assess knowledge and perception of the response to COVID-19 among health staff. …”
Publicado 2020
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31085por Wu, Sheng, Nitschke, Katja, Worst, Thomas Stefan, Fierek, Alexander, Weis, Cleo-Aron, Eckstein, Markus, Porubsky, Stefan, Kriegmair, Maximilian, Erben, Philipp“…BACKGROUND: Growing evidence supports the pivotal role of long non-coding RNAs (lncRNAs) in the regulation of cancer development and progression. …”
Publicado 2020
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31086por Vaillant-Beuchot, Loan, Mary, Arnaud, Pardossi-Piquard, Raphaëlle, Bourgeois, Alexandre, Lauritzen, Inger, Eysert, Fanny, Kinoshita, Paula Fernanda, Cazareth, Julie, Badot, Céline, Fragaki, Konstantina, Bussiere, Renaud, Martin, Cécile, Mary, Rosanna, Bauer, Charlotte, Pagnotta, Sophie, Paquis-Flucklinger, Véronique, Buée-Scherrer, Valérie, Buée, Luc, Lacas-Gervais, Sandra, Checler, Frédéric, Chami, Mounia“…Since defective mitochondria homeostasis plays a pivotal role in AD pathogenesis, targeting mitochondrial dysfunctions and/or mitophagy by counteracting early APP-CTFs accumulation may represent relevant therapeutic interventions in AD. …”
Publicado 2020
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31087por Li, Wenli, Deng, Chuiwen, Yang, Hanbo, Lu, Xin, Li, Shanshan, Liu, Xia, Chen, Fang, Chen, Lida, Shu, Xiaoming, Zhang, Lu, Liu, Qingyan, Wang, Guochun, Peng, Qinglin“…Dermatomyositis (DM) is an autoimmune disease, in which T cell dysregulation plays a pivotal role, and importantly, it is a common immune-related adverse event in response to treatment of cancers with immune checkpoint inhibitors, but no studies have implicated the TIGIT/CD226 axis in DM. …”
Publicado 2021
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31088por Huang, Sha, He, Tianyu, Yang, Sijia, Sheng, Hongxu, Tang, Xiuwen, Bao, Feichao, Wang, Yiqing, Lin, Xu, Yu, Wenfeng, Cheng, Fei, Lv, Wang, Hu, Jian“…Metformin-mediated downregulation of Nrf2 plays a pivotal role in overcoming drug resistance in NSCLC cells. …”
Publicado 2020
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31089“…Respondents identified community-level leaders as potentially pivotal stakeholders, particularly where school governance arrangements draw heavily on community representation. …”
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31090por Hou, Pingfu, Meng, Sen, Li, Minle, Lin, Tian, Chu, Sufang, Li, Zhongwei, Zheng, Junnian, Gu, Yuming, Bai, Jin“…BACKGROUND: Increasing studies have shown that long noncoding RNAs (lncRNAs) are pivotal regulators participating in carcinogenic progression and tumor metastasis in colorectal cancer (CRC). …”
Publicado 2021
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31091por Labeau, Sonia O., Afonso, Elsa, Benbenishty, Julie, Blackwood, Bronagh, Boulanger, Carole, Brett, Stephen J., Calvino-Gunther, Silvia, Chaboyer, Wendy, Coyer, Fiona, Deschepper, Mieke, François, Guy, Honore, Patrick M., Jankovic, Radmilo, Khanna, Ashish K., Llaurado-Serra, Mireia, Lin, Frances, Rose, Louise, Rubulotta, Francesca, Saager, Leif, Williams, Ged, Blot, Stijn I.“…Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat. …”
Publicado 2020
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31092por Kadioglu, Onat, Saeed, Mohamed, Mahmoud, Nuha, Azawi, Shaymaa, Mrasek, Kristin, Liehr, Thomas, Efferth, Thomas“…TP53 (p53) is a pivotal player in tumor suppression with fifty percent of all invasive tumors displaying mutations in the TP53 gene. …”
Publicado 2021
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31093por Gonzalez, Pedro L., Rappo, Urania, Mas Casullo, Veronica, Akinapelli, Karthik, McGregor, Jennifer S., Nelson, Jennifer, Nowak, Michael, Puttagunta, Sailaja, Dunne, Michael W.“…We present nephrotoxicity rates for patients with ABSSSI who received dalbavancin in three pivotal clinical trials and compare the rates with vancomycin. …”
Publicado 2021
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31094por Lan, Qingping, Ren, Zhitao, Chen, Yan, Cui, Guozhen, Choi, I. Cheong, Ung, Carolina Oi Lam, Yu, Hon Ho, Lee, Simon Ming-Yuen“…The administration of QSHY increased hepatic mRNA levels of Transcription Factor 1 alpha (HNF1A), Hepatocyte Nuclear Factor 4 alpha (HNF4A) and Forkhead box protein A3 (FOXA3) which play a pivotal role in Hepatic stellate cell (HSCs) reprogramming. …”
Publicado 2021
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31095Rate of central corneal thickness changes in primary angle closure eyes: long-term follow-up results“…BACKGROUND: Central corneal thickness (CCT) and its association with intraocular pressure, which is a pivotal parameter in glaucoma management, has previously been reported. …”
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31096por Bullock, Laurna, Crawford-Manning, Fay, Cottrell, Elizabeth, Fleming, Jane, Leyland, Sarah, Edwards, John, Clark, Emma M, Thomas, Simon, Chapman, Stephen, Gidlow, Christopher, Iglesias, Cynthia P, Protheroe, Joanne, Horne, Robert, O’Neill, Terence W, Mallen, Christian, Jinks, Clare, Paskins, Zoe“…PURPOSE: The clinical consultation is of pivotal importance in addressing barriers to treatment adherence. …”
Publicado 2021
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31097por Yari, Arezoo, Soofimajidpoor, Marzieh, Moradi, Ghobad, Bidarpoor, Farzam, Nadrian, Haidar, Iranpoor, Abedin, Zokaie, Mehdi, Raoshani, Daem, Ghotbi, Nahid, Zarezadeh, Yadolah“…BACKGROUND: Health literacy is essential to self-care, which is an important precedence to improve the quality of healthcare services and a key factor in health. It also plays a pivotal role in decision-making in various health fields. …”
Publicado 2021
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31098por Segú-Vergés, Cristina, Coma, Mireia, Kessel, Christoph, Smeets, Serge, Foell, Dirk, Aldea, Anna“…The MoA models showed that in the autoinflammatory/systemic phases of Still’s disease, in which the innate immunity plays a pivotal role, the IL-1β-neutralizing antibody canakinumab is more efficient than the IL-6 receptor-inhibiting antibody tocilizumab. …”
Publicado 2021
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31099por Zhong, Xin, Xuan, Feichao, Qian, Yun, Pan, Junhai, Wang, Suihan, Chen, Wenchao, Lin, Tianyu, Zhu, Hepan, Wang, Xianfa, Wang, Guanyu“…BACKGROUND: Preoperative evaluation of lymph node (LN) state is of pivotal significance for informing therapeutic decisions in gastric cancer (GC) patients. …”
Publicado 2021
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31100“…To mitigate possible errors introduced by a poor selection of such boundaries, a rational approach suggests to focus the modeling efforts on the pivotal ones. METHODS: In this work, we present a methodology for the automatic identification of the key fluxes in genome-wide constraint-based models, by means of variance-based sensitivity analysis. …”
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