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  1. 31181
    “…Regional syntheses of climate change impacts on vegetation are pivotal to identify and guide research priorities. …”
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    Understanding climate change impacts on biome and plant distributions in the Andes: Challenges and opportunities
  2. 31182
    “…Neuronal activity is exquisitely dependent on the control of Ca(2+) homeostasis: its alterations ultimately play a pivotal role in the origin and progression of many neurodegenerative processes. …”
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    The ataxia-linked E1081Q mutation affects the sub-plasma membrane Ca(2+)-microdomains by tuning PMCA3 activity
  3. 31183
    “…We elucidated mechanism of the binding of HDV-III HDAg-L to CHC and confirmed the pivotal role of clathrin binding in the assembly of genotype III HDV. …”
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    Identification of a novel interaction site between the large hepatitis delta antigen and clathrin that regulates the assembly of genotype III hepatitis delta virus
  4. 31184
    “…Furthermore, we presume that the installation of metabolic regeneration cycles such as supporting carbon re-entry towards the pentose phosphate pathway from C(1)-metabolism is a pivotal target for synthetic methylotrophy.…”
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    Synthetic methylotrophic yeasts for the sustainable fuel and chemical production
  5. 31185
    “…DNA Ligase III (LIG3) exerts a pivotal role in Alternative-Non-Homologous End Joining Repair (Alt-NHEJ), an error-prone DNA repair pathway often up-regulated in genomically unstable cancer, such as Multiple Myeloma (MM). …”
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    Exploiting DNA Ligase III addiction of multiple myeloma by flavonoid Rhamnetin
  6. 31186
    “…Thus, identifying candidate genes controlling these traits is pivotal for efficient biofuel production. Here, six multi-locus genome-wide association (ML-GWAS) models were applied using 185 tetraploid wheat accessions to detect quantitative trait nucleotides (QTNs) for fifteen traits associated with biomass composition. …”
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    Unlocking the molecular basis of wheat straw composition and morphological traits through multi-locus GWAS
  7. 31187
    “…The 3C-like protease (3CL(pro)) is a highly conserved cysteine proteinase that plays a pivotal role in processing the viral polyprotein to create non-structural proteins (nsps) for replication and transcription of SARS-CoV-2, making it an attractive antiviral target for developing broad-spectrum antiviral agents against SARS-CoV-2. …”
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    Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses
  8. 31188
    “…In addition, immunotherapy plays a pivotal role in treating HCC. Exploring the sensitivity of immunotherapy and building predictive models are critical for HCC. …”
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    Identification of the cuproptosis-related molecular subtypes and an immunotherapy prognostic model in hepatocellular carcinoma
  9. 31189
    “…BACKGROUND: As care homes play an important role in the lives of an increasing number of older people, it is pivotal to understand how residents’ and their families engage in decision-making about their care and support. …”
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    The factors that influence care home residents’ and families’ engagement with decision-making about their care and support: an integrative review of the literature
  10. 31190
    “…The PPI network showed that immune and inflammation-related targets played a pivotal role. The KEGG analysis found that the PI3K-Akt signaling pathway, cell cycle and MAPK signaling pathway may be the main pathways for Cynarine to prevent and treat NAFLD. …”
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    Mechanisms of Cynarine for treatment of non-alcoholic fatty liver disease based on the integration of network pharmacology, molecular docking and cell experiment
  11. 31191
    “…CONCLUSION: Our study elucidated that the immunization status among children aged between 12 and 35 months in Lao PDR is satisfactory in improving access to healthcare by strengthening communication with residents regarding health service utilization, and expanding mobile outreach services may play a pivotal role in this endeavor. Further research is warranted to evaluate efforts to increase immunization coverage and target populations with limited access to healthcare.…”
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    The determinants of immunization coverage among children aged between 12 and 35 months: a nationwide cross-sectional study in Lao People’s Democratic Republic
  12. 31192
    “…Microbiota-gut-brain axis signaling plays a pivotal role in mood disorders. The communication between the host and the gut microbiota may involve complex regulatory networks. …”
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    Exploration of the relationship between gut microbiota and fecal microRNAs in patients with major depressive disorder
  13. 31193
    “…CONCLUSION: The reduced expression of CD44v3 suppresses the proliferation and decidualization of HESCs, which might play a pivotal role in poor endometrial receptivity in women with RIF. …”
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    Decreased CD44v3 expression impairs endometrial stromal cell proliferation and decidualization in women with recurrent implantation failure
  14. 31194
    “…As the causal variations results in the change in expression, gene expression analyses carry a pivotal role in unraveling the transcriptional regulatory mechanisms behind the phenotypes. …”
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    Co-expression pan-network reveals genes involved in complex traits within maize pan-genome
  15. 31195
    “…This study hypothesized that DNA promoter methylation of the pivotal genes in the vitamin D metabolic pathway might be related to diabetes and tuberculosis co-morbidity (TB-DM) susceptibility. …”
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    Association Between Promoter Methylation of Vitamin D Metabolic Pathway Genes and Tuberculosis and Diabetes Comorbidity in a Chinese Han Population: A Case–Control Study
  16. 31196
    “…BACKGROUND: Many studies have compared real-world clinical outcomes of immunotherapy in patients with metastatic non-small cell lung cancer (NSCLC) with reported outcomes data from pivotal trials. However, any differences observed could be only limitedly explored further for causation because of the unavailability of individual patient data (IPD) from trial participants. …”
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    Individual patient data to allow a more elaborated comparison of trial results with real-world outcomes from first-line immunotherapy in NSCLC
  17. 31197
    “…Reduction in parasite density plays a pivotal role in disease outcome by minimizing all aspects of malaria pathogenesis. …”
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    Genetic variations in human ATP2B4 gene alter Plasmodium falciparum in vitro growth in RBCs from Gambian adults
  18. 31198
    “…BACKGROUND: In early 2020, following the start of the coronavirus disease 2019 (COVID-19) pandemic, institutions of higher education (IHEs) across the United States rapidly pivoted to online learning to reduce the risk of on-campus virus transmission. …”
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    COVID-19 prevention at institutions of higher education, United States, 2020–2021: implementation of nonpharmaceutical interventions
  19. 31199
    “…CONCLUSIONS: The current genomic datasets provide pivotal genetic resources to determine the phylogenetic relationships, variety identification, breeding and resource exploitation, and future genetic diversity-related studies of T. vernicifluum. …”
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    Chloroplast genome sequence of triploid Toxicodendron vernicifluum and comparative analyses with other lacquer chloroplast genomes
  20. 31200
    “…Despite the understanding that macrophage inflammation has a pivotal role in the pathophysiology of MI/R, the contribution of macrophage inflammatory signals in tailoring the function of vascular endothelium remains unknown. …”
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    NEDD4 ameliorates myocardial reperfusion injury by preventing macrophages pyroptosis
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